Recombinant Mouse Regulator of G-protein signaling 9 (Rgs9)

1. Association with the plasma membrane is sufficient for potentiating catalytic activity of RGS7 and RGS9-2 proteins. PMID: 26811338
2. Data show that the regulator of G-protein signaling 9-2 (RGS9-2) in the nucleus accumbens (NAc) affects the expression of many genes known to be involved in nociception, analgesia, and antidepressant drug actions. PMID: 26305935
3. role in sensory and mood related symptoms of neuropathic pain PMID: 25150149
4. gene regulation in the Striatum of RGS9-deficient mice PMID: 24663062
5. The complex of G protein regulator RGS9-2 and Gbeta(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum. PMID: 22932702
6. The expression of RGS9 in two distinct populations of neural precursor cells demonstrates that RGS9 and its accessory proteins may play an important role in neuronal development. PMID: 21616123
7. RGS9 knockout causes a short delay in light responses of ON-bipolar cells. PMID: 22096596
8. These studies with humans, rats and mice implicate RGS9-2 as a factor in regulating body weight. PMID: 22132185
9. RGS9-2 may play a crucial role in opiate-mediated analgesic mechanisms at the level of the spinal cord. PMID: 21741448
10. In this study, we report an identification of Hsc70 (Heat shock cognate protein 70) as a critical mediator of RGS9-2 expression that is specifically recruited to the intrinsically disordered C-terminal domain of RGS9-2 following dissociation from R7BP. PMID: 20095651
11. The localization of RGS9-2 immunoreactivity at the base or neck of spines along dendritic shafts suggests that they are mainly localized at inhibitory post-synaptic sites or extrasynaptic sites near the excitatory synapses. PMID: 19912469
12. identification of protein kinase C isozymes responsible for phosphorylation at Ser475 PMID: 12499365
13. study demonstrates that the long regulator of G-protein signaling 9 isoform contains a C-terminal domain that provides high-affinity interaction with its target G protein PMID: 12818172
14. data demonstrate a functional interaction between RGS9-2 and D2 receptor signaling and the behavioral actions of psychostimulants and suggest that psychostimulant induction of RGS9-2 represents a compensatory adaptation that diminishes drug responsiveness PMID: 12818179
15. opiate-induced changes in RGS9 levels contribute to the behavioral and neural plasticity associated with chronic opiate administration PMID: 14595021
16. photoreceptors R9AP determines the stability of the RGS9.Gbeta5 complex, and therefore all three proteins, RGS9, Gbeta5 , and R9AP, are obligate members of the regulatory complex that speeds the rate at which transducin hydrolyzes GTP. PMID: 14625292
17. In the mouse, R9AP is detectable predominantly in photoreceptors, but it is also weakly expressed in other areas of the central nervous system. It may target GTPase-activating proteins to specific membranous compartments. PMID: 14664818
18. Tolerance that develops following an adequate dose of morphine is caused by the stabilization and retention of mu receptor-activated Galpha subunits by RGS9-2 proteins. PMID: 15632124
19. Changes in RGS9-2 may be a key factor in the pathway leading from D2 dopamine receptors to the side effects from the treatment of psychoses & Parkinson's disease. PMID: 15728856
20. RGS9-2 plays an essential role in opiate actions by negatively modulating mu-opioid receptor downstream signaling PMID: 17725581
21. RGS9 knockout mice have decreased motor coordination on the rotarod and deficits in working memory but exhibit normal locomotor activity, anxiety-like behavior, cue and contextual fear conditioning, startle threshold, and pre-pulse inhibition. PMID: 18073128
22. RGS9-2 possesses specific degradation determinants which target it for constitutive destruction by lysosomal cysteine proteases. PMID: 18094251
23. versatility of RGS9-2 results from its ability to inactivate the G protein, transducin, regardless of its effector interactions, whereas RGS9-1 prefers the G protein-effector complex PMID: 19098104
24. The new kinetic scheme and analysis explain how and why RGS9 concentration matters in rod phototransduction, and they provide a framework for understanding the molecular mechanisms that rate-limit deactivation in other G-protein systems. PMID: 19751658

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KEGG: mmu:19739

STRING: 10090.ENSMUSP00000020920

UniGene: Mm.38548