Recombinant Mouse Reticulon-4 receptor (Rtn4r)

1. Nogo-A and NgR1 interactions may contribute to axonal branching in lateral olfactory tract development PMID: 28000762
2. determine the expression pattern of NgR1 in the retina by co-labeling neurons with characterized markers of specific retinal neurons PMID: 29768445
3. NgR1 ligand has a role in in oligodendrocyte progenitor cells fate in the context of a specific and common type of stroke PMID: 27956620
4. The results of this study indicated that Nogo-66 signaling limits LTP via the ROCK2-Cofilin pathway to control the dynamics of the actin cytoskeleton. PMID: 27166169
5. Results demonstrated that nogo receptor 1 (NgR1) expression is upregulated in the olfactory epithelium (OE) after injury, which suggests that NgR1 might be involved in the regeneration of the OE. PMID: 27138950
6. Here we identify that the nogo-66 receptor 1 gene restricts an early and essential step in OD plasticity to the critical period. These findings link the emerging circuit-level description of OD plasticity to the genetic regulation of the critical period. Understanding how plasticity is confined to critical periods may provide clues how to better treat amblyopia. PMID: 27798181
7. Nogo Receptor 1 limits ocular dominance plasticity but not turnover of axonal boutons in a model of amblyopia PMID: 25662716
8. Results show that Nogo receptor 1 is a negative regulator of both structural synaptic plasticity and dendritic complexity in a brain region-specific manner, and highlight anterior cingulate cortex as a key area for memory-related plasticity. PMID: 26838771
9. Rtn4r expression was reduced in spinal motor neurons from mice with a transgenic model of ALS. PMID: 26083872
10. This study detected the expression of NgR1 in microglia during development and found that NgR1 protein expression increased significantly in microglia with aging. PMID: 26367446
11. Ngr1 regulates tactile and motor task performance, it does not limit the rate of tactile or motor learning nor determine the low set point for synaptic turnover in adult sensory cortex. PMID: 25386856
12. the Nogo/NgR signal might be involved in multiple processes in various inflammation-associated CNS diseases. PMID: 26472924
13. Genetic ablation of NgR1 may lead to significant recovery in locomotor function after spinal cord injury PMID: 24594926
14. NgR1 is required for efficient infection of primary cortical neurons by reovirus. PMID: 24922571
15. NogoA receptors, NogoR1 and PirB, are expressed in the ventricular zone where neural stem cells reside. PMID: 24449409
16. NgR1 functions with parvalbumin interneurons to limit plasticity of binocularity, but its expression is required more extensively to limit improvement of visual acuity following chronic deprivation. PMID: 25164659
17. NgR1 has little if any effects on the repertoire of immune cells, their activation and trafficking to the CNS. PMID: 24339996
18. ngr(-/-) animals show slower acquisition of a spatial learning and memory task PMID: 22260793
19. These data suggest that NgR1 negatively influences plasticity and cognitive recovery after traumatic brain injury PMID: 22967270
20. NgR1 determines the low set point for synaptic turnover in adult cerebral cortex PMID: 23473316
21. findings reveal a new function for Nogo-A and NgR1 in the homeostatic regulation of the pace of neurogenesis and neuroblast migration. PMID: 23223298
22. Nogo receptor and Nogo-A are actively regulated in experimental autoimmune encephalomyelitis (EAE) lesions, indicating a specific time window for localized axonal regeneration in the acute phase of EAE. PMID: 22964785
23. The results of this study identify NgR1 and NgR3 as CSPG receptors, suggest that there is functional redundancy among CSPG receptors, and provide evidence for shared mechanisms of MAI and CSPG inhibition. PMID: 22406547
24. Data show that genetic deletion of both receptors does not promote functional recovery during EAE and that NgR1 and NgR2-mediated signals play a minor role in the development of CNS inflammation. PMID: 22096481
25. These findings suggest that the UA/EC region is a functional domain of LOTUS serving for an antagonistic action to NgR1. PMID: 22281491
26. The results of this study suggested that NgR1, a receptor previously shown to restrict axon growth in the adult, also functions in the dendrite as a barrier that limits excitatory synapse number during brain development. PMID: 22325200
27. These results indicate that a lack of NgR1/2 expression promotes the adhesion of DCs to myelin. PMID: 21906273
28. Neuronal knockdown of MT3-matrix metalloproteinase resulted in the accumulation of NgR1 at the cell surface and reduced the accumulation of the NgR1 cleavage fragment in medium conditioned by cortical neurons PMID: 21768085
29. found CRTAC1-B(LOTUS)is key molecule for lateral olfactory tract(LOT)formation; NgR1 is LOTUS-binding protein;LOTUS suppressed Nogo-NgR1 binding and Nogo-induced growth cone collapse;suggest endogenous antagonism of NgR1 by LOTUS crucial for LOT formation PMID: 21817055
30. A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1. PMID: 21454605
31. Thus either NgR gene deletion or exercise training benefits mice with mild cervical spinal injury PMID: 20809785
32. NgR1 and paired Ig-like receptor-B (PirB) participate in ligand-dependent inhibition of synaptic plasticity in hippocampal slice cultures of adult mice. PMID: 20844138
33. the structure of Nogo-66 requires interactions with a phosphocholine surface for protein folding at the membrane interface PMID: 20351248
34. NgR and its ligand Nogo-A/B exist on mouse blastocysts and cultured ES cells, suggesting NgR might play a role in early embryo development. PMID: 19400741
35. Nogo receptor 1 regulates formation of lasting memories. PMID: 19915139
36. results suggest that Nogo may be involved in axon guidance by (i) preventing recrossing of axons across the midline through an upregulation of axonal NgR and (ii) partitioning axons in the ventral funiculus into longitudinal fascicles PMID: 19833111
37. Nogo-66 retards neurite outgrowth and induces growth cone collapse by its interaction with NgR and as yet unidentified transmembrane coreceptors. PMID: 11891768
38. Myelin-associated glycoprotein(MAG) binds directly, with high affinity, to NgR; MAG and Nogo-66 activate NgR independently and serve as redundant NgR ligands that may limit axonal regeneration after CNS injury PMID: 12089450
39. Localization of Nogo-66 receptor at sites of axon-myelin and synaptic contact PMID: 12097502
40. Nogo-66-R mRNA expression in humans and mice was observed in neurons of the developing nervous system; expression was downregulated in the adult spinal cord of both species, and specific expression patterns were seen in the adult brain. PMID: 12378589
41. The NgR antagonist extracellular peptide 1-40 promotes growth of corticospinal axons, serotonergic fibers and upregulation of the small proline-rich repeat protein 1A, and synapse reformation after spinal cord injury. PMID: 12764110
42. Nogo receptor mRNA is expressed in the adult by both principal and local-circuit hippocampal neurons. PMID: 15121177
43. These results are supportive of hypothesis that Nogo-NgR axis is major path for inhibition of spinal cord axonal regeneration and uphold promises of these neutralizing agents in clinical applications. (Review) PMID: 16092935
44. mutations in the Nogo-66 receptor (NgR) affect cessation of ocular dominance plasticity; physiological NgR signaling from myelin-derived Nogo, MAG, and OMgp consolidates the neural circuitry established during experience-dependent plasticity PMID: 16195464
45. The Nogo-66/NgR system is involved in regneeration of entorhinal/hippocamal axonal lesions in in vitro. PMID: 16407455
46. role for Nogo receptors (NgRs) in macrophage efflux from sites of inflammation in peripheral nerve PMID: 17329206
47. RTN4R may modulate the genetic risk or clinical expression of schizophrenia in a subset of patients and identify additional studies that will be necessary to clarify the role of RTN4R in psychiatric phenotypes PMID: 18043741
48. Nogo receptor antagonizes p75NTR-dependent motor neuron death PMID: 18182498
49. Expression patterns suggest an interaction of Nogo with its receptor in the mouse retinofugal pathway, which may be involved in guiding axons into the optic pathway and in governing the routing of axons in the optic chiasm. PMID: 18214994
50. gangliosides inhibit neurite outgrowth by interacting with FRG motifs in the NgR1 and this interaction can also facilitate the binding of MAG to the NgR1 PMID: 18411262

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KEGG: mmu:65079

STRING: 10090.ENSMUSP00000062924

UniGene: Mm.40149