Recombinant Mouse Rho guanine nucleotide exchange factor 2 (Arhgef2), partial

1. GEF-H1 was a novel regulator of inflammatory cytokine production and mycobacterial elimination, and may serve as a novel potential target for clinical treatment of tuberculosis. PMID: 28783414
2. Autophagic regulation of RhoA activity was dependent on GEF-H1 which directly bound to p62 and was degraded by autophagy, resulting in low RhoA activity. In contrast, the loss of autophagy increased GEF-H1 levels and thereby activated RhoA, which caused cells to move by amoeba-like migration. This amoeba-like migration was cancelled by the silencing of GEF-H1. PMID: 27120804
3. human brain malformation is recapitulated in Arhgef2 mutant mice and identify an aberrant migration of distinct components of the precerebellar system as a pathomechanism underlying the midbrain-hindbrain phenotype. Our results highlight the crucial function of ARHGEF2 in human brain development and identify a mutation in ARHGEF2 as novel cause of a neurodevelopmental disorder. PMID: 28453519
4. These results identify GEF-H1 as a component of the shear stress response machinery in neutrophils required for a fully competent immune response to bacterial infection. PMID: 27738004
5. Study describes a new mode of GEF-H1 activation in response to G-protein-coupled receptor (GPCR) ligands that is independent of microtubule depolymerization. PMID: 25209408
6. Data show that the activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I-like receptors. PMID: 24270516
7. Pak2, but not Pak1, negatively regulates RhoA via phosphorylation of the guanine nucleotide exchange factor GEF-H1 at an inhibitory site, leading to increased GEF-H1 microtubule binding and loss of RhoA stimulation PMID: 23204526
8. It was shown that the guanine exchange factors GEF-H1 and ECT2 must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 downregulation. PMID: 22387001
9. CAPN6 acts as a regulator of Rac1 and cell motility through interaction with GEF-H1. PMID: 21406564
10. LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras PMID: 21572419
11. p114-RhoGEF and Lfc are critically involved in Wnt-3a- and Dvl-induced RhoA activation and neurite retraction in N1E-115 cells. PMID: 20810787
12. Depletion of GEF-H1 in the murine two-hit model of VILI attenuated vascular leak induced by lung ventilation at high tidal volume and thrombin-derived peptide TRAP6. PMID: 20348280
13. Enteropathogenic Escherichia coli type III effectors, EspG and its homolog Orf3, trigger the activation of the RhoA-ROCK signaling pathway via GEF-H1 PMID: 15318166
14. PAK4 mediates morphological changes through regulation of GEF-H1 PMID: 15827085
15. Microtubule-associated RhoGEF Lfc is required for the formation of the mitotic spindle during prophase/prometaphase. PMID: 15976019
16. Thus, Lfc and Tctex-1 interact to regulate cortical neurogenesis, potentially by regulating mitotic spindle orientation. PMID: 19448628

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KEGG: mmu:16800

STRING: 10090.ENSMUSP00000029694

UniGene: Mm.239329