Recombinant Mouse Serine/threonine-protein kinase receptor R3 (Acvrl1), partial

1. our data show that in a tumor environment BMP9 and BMP10 play different roles and thus blocking their shared receptor ALK1 is maybe not appropriate. Indeed, BMP9, but not BMP10, acts as a quiescence factor on tumor growth, lung metastasis and vessel normalization. PMID: 30165893
2. These studies identified pathways mediating LDLR-independent uptake of LDL may provide unique opportunities to block the initiation of LDL accumulation in the vessel wall or augment hepatic LDLR-dependent clearance of LDL. PMID: 27869117
3. We have identified a novel role for ALK1 in cardiac remodeling PMID: 28820968
4. Data show that concomitant activin receptor-like kinase 1 (Acvrl1) and endoglin (Eng) deficiency synergistically decreases pancreatic neuroendocrine tumor volume. PMID: 27741515
5. Global deletion of AlK-1 is associated with the development of high output heart failure without maladaptive remodeling. PMID: 28213819
6. These data indicate that both Itgb8 and Alk1 are important in maintaining normal cerebral angiogenesis in response to VEGF. Itgb8 deficiency enhances the formation of dysplastic vessels and hemorrhage in Alk1 (+/-) mice. PMID: 27352867
7. these studies characterize an accessory TGF-beta-stimulated BMP R-Smad signaling mechanism in interstitial cells of the developing lung. PMID: 28642261
8. this study demonstrates that ACVRL1 signaling plays a pivotal role whereby it suppresses plasmacytoid dendritic cell development while enhancing that of CD8alpha(+) dendritic cells, thus contributing to DC diversity development. PMID: 27421479
9. CD109 differentially regulates TGF-beta-induced ALK1-Smad1/5 versus ALK5-Smad2/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 expression regulates dermal function through a paracrine mechanism PMID: 27866969
10. he results of the present study demonstrated that BMP9 promoted the osteoclast differentiation of osteoclast precursors via binding to the ALK1 receptor on the cell surface, and inhibiting the ERK1/2 signaling pathways in the cell PMID: 27748860
11. Conclude that the ALK-1 receptor is involved in the control of arterial pressure. High AP of Alk1(+/-) mice is explained mainly by the sympathetic overactivation, which is probably related to the decreased number of cholinergic neurons. PMID: 26398936
12. Report interaction between ALK1 signaling and connexin40 in the development of arteriovenous malformations. PMID: 26821948
13. In vascular sprouting, neuropilin-1 suppresses the stalk-cell phenotype by limiting Smad2/3 activation through Alk1 and Alk5. Notch downregulates Nrp1, thus relieving the inhibition of Alk1 and Alk5, thereby driving stalk-cell behaviour. PMID: 26081042
14. BMP9/ALK1 augmented vasculogenesis and angiogenesis, and thereby enhanced neovascularization. Thus, we suggest that BMP9/ALK1 may improve the efficacy of EPC-based therapies for treating ischemic diseases. PMID: 26229139
15. BMP-9 induces vascular smooth muscle cell osteogenic differentiation and calcification via ALK1, Smad and ALP dependent mechanisms. PMID: 25297851
16. during development, endothelial Acvrl1 plays an essential role to regulate endothelial cell proliferation and arterial identity during angiogenesis, whilst in adult life endothelial Acvrl1 is required to maintain vascular integrity. PMID: 24896812
17. Results show that ALK5 and ALK1 play antagonistic roles in TGF-beta-induced podosome formation in aortic endothelial cells. PMID: 25266657
18. ALK1 modulates obstruction-induced renal fibrosis by increased extracellular matrix synthesis in myofibroblasts, but without differences in myofibroblast number. PMID: 23945497
19. the mechanisms responsible for the angiogenic imbalance and the response to anti-VEGF therapy differ between Eng and Alk1 heterozygous mice and raise the need for systemic monitoring of anti-angiogenic therapy effects in HHT patients. PMID: 24061911
20. Deletion of Alk1 in endothelial cells in adult mice leads to an increased local endothelial cell proliferation during brain angiogenesis PMID: 24457293
21. FGF2 inhibited BMP9-induced osteogenic differentiation by blocking BMP9-induced Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2 in mesenchymal stem cells. PMID: 23680673
22. ALK-1 signals inhibit lymphatic vessel (LV) formation, and LVs were enlarged in multiple organs in Alk1-depleted mice. PMID: 24133138
23. Endoglin contributes to both shear induced collateral artery growth and to ischaemia induced angiogenesis, whereas ALK1 is only involved in ischaemia induced angiogenesis. PMID: 22436015
24. Reduction of mural cell coverage in response to vascular endothelial growth factor stimulation is a potential mechanism for the impairment of vessel wall integrity in Alk1-deficient mouse brain. PMID: 23241407
25. ALK1 is upregulated in endothelial cells during vascular injury by a synergistic cooperative mechanism between KLF6 and specificity protein 1. PMID: 23048070
26. Deletion of Eng induces more severe cerebrovascular dysplasia per copy than that of Alk1 upon VEGF stimulation. PMID: 22571958
27. PTPN14 has a role in angiogenesis and/or arteriovenous fate, acting via EphrinB2 and ACVRL1/activin receptor-like kinase 1 PMID: 22233626
28. The results uncovered a direct link between ALK1 and Notch signaling during vascular morphogenesis that may be relevant to the pathogenesis of hereditary hemorrhagic telangiectasia vascular lesions. PMID: 22421041
29. Increased pulmonary vascular remodelling in Alk1(+/-) mice leads to signs of pulmonary hypertension and is associated with eNOS-dependent ROS production, which is preventable by anti-oxidant treatment. PMID: 21859819
30. Kidneys of ALK(+/+) and ALK1(+/-) mice were irradiated with 14 Gy. ALK1(+/-) mice develop a delayed normal tissue response by modulating the inflammatory response and growth factor expression after irradiation. PMID: 21704403
31. ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth PMID: 20124460
32. Results strongly suggest that ALK1 and ALK2 may play an important role in mediating BMP9-induced osteogenic differentiation. PMID: 20628059
33. a novel aspect of ALK1 signaling in regulating lymphatic development and suggests that targeting ALK1 pathway might provide additional control of lymphangiogenesis in human diseases. PMID: 19903896
34. Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. PMID: 20065063
35. endoglin and Alk1 are necessary for the maintenance of distinct arterial-venous vascular beds PMID: 12941632
36. Using a series of transgenic constructs with various Alk1 genomic fragments joined to a reporter, it seems a 9.2-kb genomic fragment including the 2.7-kb promoter region & the whole intron 2 is sufficient for arterial endothelium-specific expression. PMID: 15059937
37. ALK-1, an orphan receptor in the TGF-beta family, is a potential receptor for BMP-9 PMID: 15851468
38. Endoglin has a role in response to transforming growth factor beta1 and activation of Alk1 pathway PMID: 15923183
39. ALK1 overexpression results in inhibition of bFGF-induced corneal neovascularization in vivo. PMID: 16223497
40. In differentiated endothelial stem cells ALK1 is implicated in mediating transforming beta 1 inhibition of sprouting angiogenesis. PMID: 17071858
41. Results from this study provide valuable information regarding the role of ALK1 in the development of placental vasculature as well as insights into the pathogenesis of HHT. PMID: 17530030
42. neither ALK5 nor TGFBR2 is required for ALK1 signaling pertinent to the pathogenesis of HHT and suggest that HHT might not be a TGF-beta subfamily disease. PMID: 17911384
43. Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. PMID: 18835925
44. Eng was more widely expressed than Acvrl1 in lungs. Association of ACVRL1 mutations with pulmonary artery hypertension underlines importance of ACVRL1 expression in distal arteries affected in this disorder. PMID: 19015642
45. age-related shift in ALK1/ALK5 ratio in murine cartilage and a strong correlation between ALK1 and MMP-13 expression in human cartilage PMID: 19494318

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KEGG: mmu:11482

STRING: 10090.ENSMUSP00000000542

UniGene: Mm.279542