Recombinant Mouse Sodium- and chloride-dependent glycine transporter 1 (Slc6a9), partial

1. GlyT1 and not GlyT2 is essential for the replenishment of the presynaptic glycine pool in retinal AII amacrine cells and is a major determinant of the glycinergic phenotype of this cell population. PMID: 29808289
2. the expression of inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 in inferior colliculus and hippocampus astrocytes, was examined. PMID: 29370841
3. Whole-exome sequencing revealed a novel homozygous missense variant in exon 9 of SLC6A9 NM_201649.3: c.1219 A>G (p.Ser407Gly) that segregates with the disease within the family. In murine model, knockout of Slc6a9 is associated with equivalent phenotype of non-ketotic hyperglycinemia (NKH), namely respiratory distress and hypotonia. PMID: 27481395
4. pharmacologic or genetic abolishment of GlyT1 activity in mice leads to mildly elevated glycine in the CSF but not in blood PMID: 27773429
5. Study demonstrated a biphasic response of GlyT1 expression during epileptogenesis with initial downregulation of GlyT1 after epileptogenesis-precipitating seizures followed by sustained pathological overexpression of GlyT1 in chronic epilepsy PMID: 26302655
6. Results suggest that the excessive GAT-1 and GlyT-1/2 heterotransporter-mediated Glu release, in the spinal cord of SOD1(G93A) mice, is due to the heterotransporter over-expression at the nerve terminal membrane, promoted by the excessive Glu exocytosis PMID: 25497732
7. the possible involvement of calmodulin or calmodulin-like interactions in the regulation of GlyT1 C-mediated transporter trafficking PMID: 25168305
8. Disruption of GlyT1 in forebrain neurons does not increase the risk of forming spurious and potentially maladaptive fear associations. PMID: 25043729
9. The demonstrated increased sensitivity to the effect of CS-US temporal discontiguity further highlights the importance of GlyT1-dependent mechanisms in the regulation of associative learning. PMID: 24480413
10. This study demonistrated that the GlyT1-/+ subjects quickly reached a plateau response to AMPH, which remained stable during drug withdrawal PMID: 22763616
11. These alterations in the activities and expression profiles of the GlyTs suggest that the contributions of GlyT1 and GlyT2 to the regulation of extracellular glycine concentrations at glycinergic synapses changes during development. PMID: 22695116
12. This study demonistrated that forebrain neuronal glycine transporter 1 deficine not cause working memory disorders. PMID: 22342492
13. HMGN3a/b binding leads to increased H3K14 (Lys(14) of histone H3) acetylation and stimulates Glyt1a expression PMID: 22150271
14. These results demonstrate in mice that depending on the regional and/or cell-type specificity, deletion of the GlyT1 gene could yield divergent effects on prepulse inhibition. PMID: 20647165
15. mice with Glyt1 disruption in forebrain demonstrated enhanced adversive Pavlovian conditioning, which was modified with age. Also increase in the number of immature neurons in the hippocampus of the mutants PMID: 21038935
16. This study demonistrated that Adenoviral-mediated Cre expression effectively suppresses GlyT1 binding in the thalamic area of GlyT1 conditional knock-out mice. PMID: 20832426
17. We show that immunoreactivity against the last 12 amino acids of GlyT1C-terminal region exhibits robust calcium dependent decline PMID: 20542070
18. glial GlyT1 is critical for the regulation of glycine levels at inhibitory synapses only during early postnatal life PMID: 20468048
19. study examined the role of GlyT1, the high-affinity glycine transporter, in the retina with an emphasis on the role of glycine as a coagonist of N-methyl-D-aspartic acid (NMDA) receptor PMID: 20092573
20. GLYT1, a glycine transporter of the neurotransmitter transporter gene family, functions as the organic osmolyte transporter that mediates the osmotically regulated accumulation of glycine and regulates cell volume in early embryos. PMID: 14615585
21. During early postnatal life, GlyT1 is essential for regulating glycine concentrations at inhibitory GlyRs, and GlyT1 deletion generates symptoms found in human glycine encephalopathy PMID: 14622582
22. results suggest that HMGN3 regulates glycine transporter 1 expression and demonstrate that members of the HMGN family can regulate the transcription of specific genes PMID: 15082770
23. Data show that reduced expression of glycine transporter 1 enhances hippocampal NMDA receptor function and memory retention and protects against an amphetamine disruption of sensory gating. PMID: 15159536
24. Overall, these findings highlight the importance of GlyT1 in regulating glutamatergic neurotransmission. PMID: 15661817
25. intracellular accumulation of glycine in embryos is a direct function of the rate of glycine uptake via GLYT1 PMID: 15672418
26. Neuronal Glycine Transporter I normally assumes a specific role in the regulation of NMDA receptor responses. PMID: 16554468
27. Here we demonstrate a segregated expression of GlyT1 on different astroglial cell populations of the ventral respiratory group. PMID: 17010320
28. mice in which GlyT1 has been deleted demonstrate enhanced object recognition memory PMID: 17907847
29. These findings highlighted the possibility of a functional divergence between the neuronal and glia subpopulations of GlyT1 in the regulation of learning and memory processes. PMID: 19332109
30. Data show that GLYT1 is quiescent in mouse germinal-vesicle-stage oocytes but becomes fully activated within hours after ovulation is triggered. PMID: 19502485
31. forebrain neuronal GlyT1 may modulate the flexibility in (new) learning and relevant mnemonic functions. PMID: 19824767

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KEGG: mmu:14664

STRING: 10090.ENSMUSP00000030269

UniGene: Mm.244549