Recombinant Mouse Sodium-dependent noradrenaline transporter (Slc6a2), partial

1. Differences in gene expression in the mouse frontal cortex with life-long norepinephrine transporter knock-out were studied using a whole-genome microarray approach PMID: 26002194
2. inhibition of p38 MAPK or the manipulation of NET-Thr(30) motif/phosphorylation via a TAT peptide strategy prevents cocaine-induced NET up-regulation, locomotor sensitization, and conditioned place preference PMID: 25724654
3. this is the first report which suggests the beneficial effect of modulation of TRPV1 receptors and NET in Chronic cerebral hypoperfusion vascular dementia PMID: 24597602
4. daily sympathetic activation induced by mild chronic stress was unable to induce bone loss, unless NET activity was blocked. PMID: 24005671
5. NET dysfunction is sufficient to produce a postural orthostatic tachycardia syndrome phenotype. PMID: 23580201
6. Norepinephrine transporter has a greater role in determining baseline analgesia and other analgesic effects in mice than serotonin transporter. PMID: 21129446
7. NET expression is essential for development and/or survival of some (5-HT- and calretinin-expressing), but not all (nNOS-expressing), of these neurons. PMID: 21148012
8. propose that amplified norepinephrine transporter function in rictor KO mice enhances accumulation of both norepinephrine and dopamine within the noradrenergic neuron PMID: 20543991
9. Report a protocol to monitor NET transport rate at the level of the single nerve terminal varicosity using a fluorescent substrate. PMID: 20136837
10. We identified that gene expression in neuronal cortical cells involves increased histone hyperacetylation on the Slc6a2 promoter, which is commensurate with the recruitment of SP1 and RNA Polymerase II and is inversely correlated with H3K9 trimethylation. PMID: 20107077
11. Data demonstrate that estrogen exerts significant modulatory effects on olfactory bulb function through modulation of tyrosine hydroxylase, dopamine transporter and norepinephrine transporter expression. PMID: 12480184
12. NET function may be a physiologically relevant regulatory element in embryonic development. PMID: 12876425
13. NET deficiency increases extraneuronal levels of NE, dopamine, & epinephrine. The impact of this hyperadrenergic state is greatest in the periphery & is manifested by high blood pressure & excessive tachycardia with wakefulness & physical activity. PMID: 15337696
14. this is the first report to suggest that the norepinephrine transporter gene is one of many possible genetic factors influencing ethanol sensitivity in ILS, ISS, and LXS RI mouse strains PMID: 16269905
15. Knockout mice showed enhanced binding of the selective alpha(2)drenergic antagonist [(3)H]RX821002 in several brain regions PMID: 16417582
16. The effects of DAT KO in animal models of depression are larger than those produced by NET or SERT KO, and unlikely to be simply the result of the confounding effects of locomotor hyperactivity. PMID: 18690111
17. a novel triple mutation that retains close to wild-type transport function but displays a 37-fold decrease in cocaine sensitivity and 24-fold decrease in desipramine sensitivity. PMID: 18824182
18. Data further suggest deregulation of signaling pathways in the development and/or function of the NET-deficient peripheral, central and enteric nervous systems. PMID: 19356247
19. conditioned locomotion was not observed in DAT KO mice, and was reduced in SERT KO and NET KO mice. PMID: 19482066
20. resistance of the NET KO mice to the stress-induced depression-associated behaviors and biochemical changes highlight the importance of noradrenergic pathways in the maintenance of mood PMID: 19694905

Show More

Hide All

KEGG: mmu:20538

STRING: 10090.ENSMUSP00000072709

UniGene: Mm.57040