Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 4 (Timd4), partial

1. These results indicate that TAM and Tim4 collaborate for efficient efferocytosis in certain macrophage populations. PMID: 28768810
2. TIM-4 is expressed on iNKT cells but dispensable for their development and function. PMID: 27662666
3. TIM-4 was differentially expressed in the distinct subsets of DCs in skin and skin-draining LNs, and specifically regulated epidermal LC and LN CD207-CD4+ DC homeostasis PMID: 27224924
4. identified TIM-4 as a novel marker for B effector 1 (Be1) cells that depend on IFN-gamma for their proinflammatory activity; TIM-4(+) B cells are enriched for IFN-gamma-producing proinflammatory Be1 cells that enhance immune responsiveness and can be specifically targeted with anti-TIM-4. PMID: 28848066
5. Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4) on a proportion of CD103+ CD11b+ dendritic cell (DC) in the intestinal lamina propria (LP). PMID: 27379516
6. attenuated LPS-induced endotoxic shock by inhibiting cytokine production by macrophages PMID: 27617399
7. analysis of the molecular characteristics of both mTIM-4 and hTIM-4 provides a better understanding of the regions of the TIM-4 IgV domain critical for Ebola virus entry PMID: 27122575
8. STAT6 mediates the CT-induced TIM4 expression in DCs. In conclusion, p300 and STAT6 mediate the microbial product CT-induced TIM4 expression in DCs. PMID: 26899911
9. Blockade of Tim-4 aggravates atherosclerosis in LDL receptor knockout mice likely by prevention of phagocytosis of phosphatidylserine-expressing apoptotic cells and activated T cells by Tim-4-expressing cells. PMID: 26821944
10. results indicate that Tim-4 is involved in negative regulation of NO production in macrophages, suggesting the critical role of Tim-4 in immune related diseases PMID: 25905790
11. TIM-4 on dendritic cells plays a critical role in hepatic ischemia-reperfusion (IR) injury and may be an efficient target for the prevention of liver or other organ IR injuries. PMID: 25771178
12. M2-like TIM-4hiCD169+ tissue-resident macrophages are immunoregulatory and promote engraftment of cardiac allografts, but their influence is diminished by TIM-4-dependent programmed cell death PMID: 24983317
13. intrinsic macrophage-specific TIM-4 signaling has indispensable role in innate immunity-driven liver ischemia-reperfusion injury PMID: 25066922
14. TIM4 engages integrins as coreceptors to evoke the signal transduction needed to internalize PtdSer-bearing targets such as apoptotic cells. PMID: 24623723
15. Tim-4 expression was higher in Behcet's disease (BD) mice than that in BDN mice. PMID: 24453431
16. In addition to the known phosphatidylserine(PS) binding pocket, Tim4 has four weaker sites of interaction, making it sensitive to PS surface concentration in a manner capable of differential recognition on the basis of PS exposure level. PMID: 24706780
17. the engulfment of apoptotic cells by resident peritoneal macrophages proceeds in two steps: binding to Tim4, a PtdSer receptor, followed by MerTK-mediated cell engulfment PMID: 24515440
18. Data suggest that trans-membrane (or T cell) immunoglobulin and mucin (TIM) molecules are expressed in embryonic hematopoietic tissues in chicken and mouse and that in fetal liver, TIM-4 is expressed by myeloid progenitor cells. PMID: 24316337
19. TIM-4 directly interacted with AMPKalpha1 and activated autophagy-mediated degradation of ingested tumors, leading to reduced antigen presentation and impaired CTL responses PMID: 24315994
20. The therapeutic effect of anti-TIM-4 mAb on arthritis is mediated by the inhibition of proinflammatory cytokine production by inflammatory cells, osteoclast differentiation, and bone resorption. PMID: 24068667
21. In RAG(-/-) recipients of skin allografts adoptively transferred with CD4( ) T cells, findings show that TIM-4 blockade in vivo is associated with a 3-fold prolongation in allograft survival. PMID: 24038092
22. TIM-4-mediated clearance of antigen specific T cells represents an important previously unrecognized mechanism regulating respiratory tolerance. PMID: 23149665
23. aged female mice deficient in both MFG-E8 and Tim4 developed autoantibodies in an age-dependent manner PMID: 22723547
24. Wild type TIM-4, a receptor for phosphatidylserine (a marker of apoptotic cells) regulates adaptive immunity in part by mediating the removal of antigen-specific T cells during the contraction phase of the response. PMID: 21037090
25. These data support an indispensible role of Tim-4 in maintaining the homeostasis of resident peritoneal macrophages. PMID: 20421466
26. TIM-4 is critical for the clearance of apoptotic bodies in vivo, and that lack of TIM-4 results in aberrant persistence of apoptotic bodies leading to dysregulated lymphocyte activation and signs of systemic autoimmunity. PMID: 20368430
27. TIM-1-TIM-4 interaction is involved in regulating T cell proliferation. PMID: 15793576
28. results indicate that Tim4 and Tim1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved PMID: 17960135
29. Tim-4, expressed on APCs, is a costimulatory molecule that promotes T cell expansion and survival by cross-linking Tim-1 on T cells PMID: 18354194
30. results suggest that TIM-4 exerts bimodal functions depending on the activation status of T cells PMID: 18367551
31. concurrent exposure to cholera toxin (CT) & peanut extract (PE) increases TIM4 expression in dendritic cells(DC)& promotes DC maturation, which plays an important role in initiation of PE-specific T(H)2 polarization &allergy in the intestine PMID: 18547633

Show More

Hide All

KEGG: mmu:276891

STRING: 10090.ENSMUSP00000069456

UniGene: Mm.69002