Recombinant Mouse TRAF-type zinc finger domain-containing protein 1 (Trafd1)

Code CSB-YP667564MO
MSDS
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Source Yeast
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Code CSB-EP667564MO
MSDS
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Source E.coli
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Code CSB-EP667564MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP667564MO
MSDS
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Source Baculovirus
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Code CSB-MP667564MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Trafd1
Uniprot No.
Alternative Names
Trafd1; Fln29; TRAF-type zinc finger domain-containing protein 1; Protein FLN29
Species
Mus musculus (Mouse)
Expression Region
2-580
Target Protein Sequence
AEFRDDQAS RLCDNCKKEI PVFNFTIHEI HCQRNIGVCP VCKEPFPKSD MDIHMAAEHC QVTCKCNKKL EKRQLKQHAE TECPLRLAVC QHCDLELSVV KLKEHEDYCG ARTELCGSCG RNVLVKELKT HPEVCGRVEE EKRTEAAIPP EAYDEPWSQD RIWIASQLLR QIEALDPPMR LPGRPLQAFE ADPFYSRTTS QRSMAAQFPV QNNLFEEQER QERNRSRQSP KDSAENNAHL DFMLALSLQN EGQATSMVEQ GFWESVPEAD PARAGPTSLG DIKGAADEIL LPCEFCEELY PEELLIDHQT SCNPSHALRS LNTGSSSIRG VEDPGTIFQN FLQQATSNQF DTLMGLSSSA AVEDSIIIPC EFCGVQLEEE VLFYHQDQCD QRPATANHRA VEGIPAQDSQ PENTSAELSR RRVKHQGDLS SGYMDDVKPE SVKGPTYSMS PNRTMNNVAS CNRLLNLPSG PRSDCQRSPP GVLKLNNSDS QDIRGQMRGS QNGPIASGHA PVIHSIQNLY PENFAPSFPH GSPGRYGAGG RSEGGRSSRV SPAAAGYHSR AAKAKPPKQQ GAGDAEEEEE
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3.
Gene References into Functions
  1. TRAFD1, in association with Plekhm1/Rab7-positive late endosomes-early lysosomes, has a previously unknown role in vesicle trafficking, acidification, and resorption in osteoclasts PMID: 25992615
  2. FLN29 is a new negative feedback regulator of TLR signaling PMID: 16221674
Tissue Specificity
Expressed in skeletal muscle, brain, liver, kidney, spleen and bone marrow. Expression depends on STAT1.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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