Recombinant Mouse Translin (Tsn)

1. Thus, the authors define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax. PMID: 28927503
2. These findings indicate that miRNA depletion in dicer deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX. PMID: 25457613
3. These in vivo and in vitro findings of this study indicated that dendritic trafficking of BDNF mRNA can be mediated by both translin-dependent and -independent mechanisms. PMID: 21198640
4. trax acts to regulate translin's RNA and DNA binding affinities as part of a cellular RNA trafficking mechanism. PMID: 20450889
5. TB-RBP is involved in the posttranscriptional regulation of Gapds gene expression during spermiogenesis. PMID: 12604635
6. TB-RBP-null male mice were fertile and sired offspring but had abnormal seminiferous tubules and reduced sperm counts. Null female mice were subfertile, had reduced litter sizes; analysis of brain RNA from null mice revealed an altered gene expression PMID: 12944470
7. TB-RBP-mouse ribonucleoprotein complex transports a group of specific CREM-regulated mRNAs in mammalian male postmeiotic germ cells. PMID: 14673085
8. TB-RBP post-transcriptionally stabilizes TRAX and both proteins are needed for normal cell proliferation PMID: 14711818
9. subcellular locations of TB-RBP and TRAX in male germ cells are modulated by the relative ratios of TRAX and TB-RBP PMID: 15138261
10. During a search for RNA-induced silencing complex (RISC) proteins that directly interact with small interference RNA, the authors identify TB-RBP in NIH3T3 cell lysate and show that it possesses both single- and double-stranded RNase activities. PMID: 15491149
11. These studies have, for the first time, identified both mRNAs and a non-coding RNA as TSN targets expressed during meiosis PMID: 15987823
12. Our results in mice indicate that mutations in translin may contribute to fragile X-like syndromes, mental retardation, attention deficit hyperactivity disorder, epilepsy, and autism spectrum disorders in humans. PMID: 16495445
13. translin works with SF-1 to augment gene transcription in a DNA-specific fashion PMID: 17053042
14. Translin contributes to hematopoietic regeneration by acting as a sensor protein for radiation-induced damage PMID: 18239274
15. The binding of TSN to miR-122a increases its in vivo stability, suggesting an additional posttranscriptional function for TSN PMID: 18567644
16. Findings implicate abnormal dendritic trafficking of BDNF mRNA in the pathophysiology of neuropsychiatric disorders linked to the translin G196A mutation. PMID: 19805324
17. GTP binding site mutant and effects on RNA binding and protein binding PMID: 11691931

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KEGG: mmu:22099

STRING: 10090.ENSMUSP00000027623

UniGene: Mm.426637