Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 22 (Ptpn22), partial

1. these findings highlight PTPN22 as a novel regulator of dectin-1 signals, providing a link between genetically conferred perturbations of innate receptor signaling and the risk of autoimmune disease PMID: 28948613
2. PTPN22 role in CD8-positive t cells activation. PMID: 29116089
3. Here we show that mice deficient in PTPN22 resist chronic viral infection with lymphocytic choriomeningitis virus clone 13. The numbers and function of viral-specific CD4 T lymphocytes is greatly enhanced, whereas expression of the IFNbeta-induced IL-2 repressor, cAMP-responsive element modulator is reduced. PMID: 27799548
4. we have discovered that inactivation of Ptpn22 or Mll3 greatly accelerated PI3K-driven mammary tumorigenesis PMID: 27653681
5. Our findings, for the first time, illustrate the indirect impact of the 619 Arg > Trp polymorphic PTPN22 on T cells activation, mediated by polymorphic effects on macrophages and indicate a possible role of PTPN22 in cytoskeleton re-arrangement. PMID: 28237724
6. PTPN22 has dual roles in T-cell clonal expansion and effector function; whereas it promotes antigen-driven responses during acute infection by positively regulating interferon signaling in T cells, PTPN22 inhibits homeostatic-driven proliferation. PMID: 27725666
7. PTPN22 colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 ligand intercellular adhesion molecule-1 (ICAM-1). PMID: 27703032
8. PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells. PMID: 29040339
9. collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals PMID: 28801357
10. PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 phosphorylation, but reduced levels of mature IL-1beta. PMID: 27043286
11. We show that PTPN22 deficiency enhanced T-cell receptor-mediated signaling in SKG Ptpn22-/- thymocytes and that the early stages of thymus positive selection were partially restored in SKG Ptpn22-/- mice. PMID: 27288531
12. this study shows that neutrophil effector functions are reduced in Ptpn22-/- neutrophils, and that Ptpn22-/- mice are protected from immune complex-mediated arthritis PMID: 27807193
13. report demonstrates enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice. PMID: 27207523
14. our data suggest a critical role for GITR in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior PMID: 26810223
15. lack of PTPN22 strengthens transplant tolerance to pancreatic islets by expanding both FOXP3(+) Treg and Tr1 cells PMID: 25748328
16. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes PMID: 26438525
17. T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases. PMID: 25715232
18. PTPN22 is an inhibitor of PAD-4 and protein citrullination. PMID: 26019128
19. Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-alpha receptor signaling. PMID: 26077719
20. lack of Ptpn22 exacerbates virally-induced type 1 diabetes in lymphocytic choriomeningitis virus mice, while maintaining higher number of Treg cells in the antiviral response in the blood and spleen but not in the pancreatic lymph nodes PMID: 25513733
21. Data suggest that a gain-of-function of human PTPN22 transgene encoding the tyrosine phosphatase LYP is unlikely to increase risk of autoimmunity through alterations of thymic selection. PMID: 24498279
22. PTPN22 limited signaling via the T cell antigen receptor (TCR) by weak agonists and self antigens while not impeding responses to strong agonist antigens. PMID: 25108421
23. data demonstrate that PTPN22 controls NOD2 signaling, and loss of PTPN22 renders monocytes more reactive towards bacterial products, what might explain the association of PTPN22 variants with IBD pathogenesis PMID: 23991106
24. these findings demonstrate the importance of cell type-specific PTPN22 activity on regulation of antibody production. PMID: 24453256
25. Our data not only demonstrate a critical role of PTPN22 in regulating macrophage polarization but also provide a molecular explanation for the protective effect of the C1858T SNP in Crohn's disease PMID: 23913970
26. Data indicate that Ptpn22 regulates TLR-driven Type 1 interferon production in myeloid cells. PMID: 23871208
27. results demonstrate that Pep overexpression in T cells attenuates autoimmune diabetes in NOD mice by preferentially modulating TCR signaling-mediated functions in diabetogenic T cells but not in T(regs) PMID: 23752610
28. the disease-associated PTPN22 variant promotes systemic autoimmunity in murine models PMID: 23619366
29. Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function PMID: 23193160
30. Data suggest that an amino acid substitution mutation in Ptpn22 (R620W) resulting in a type 1 diabetes model (previously thought to be a loss-of-function mutation) is, in fact, a gain-of-function mutation. PMID: 23193190
31. An increase in regulatory T cells (Tregs) persisted in the periphery and could play a key part in reduced severity observed in PTPN22-deficient mice with experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. PMID: 22539785
32. mice expressing the Ptpn22 Lyp variant homolog Pep619W manifest thymic and splenic enlargement accompanied by increases in T-cell number, activation and positive selection and in dendritic- and B-cell activation. PMID: 21841778
33. Our results do not show that the PTPN22, STAT4 and TRAF1/C5 gene polymorphisms may confer a direct risk of cardiovascular disease disease in patients with rheumatoid arthritis. PMID: 20822712
34. central role for PEP in negatively regulating specific aspects of T cell development and function PMID: 14752163
35. Pep(-/-) T cells in the context of a susceptible microenvironment can drive hyperresponsive CD45 E613R B cells to break tolerance. PMID: 19299707

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KEGG: mmu:19260

STRING: 10090.ENSMUSP00000029433

UniGene: Mm.395