Recombinant Mouse Vascular endothelial growth factor D (Figf)

1. lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC activation by ADAMTS3 and CCBE1 spatially and temporally patterns developing lymphatics, and one in which VEGFD activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth PMID: 27159393
2. This study uncovers a reciprocal relationship between dendrite geometry, the ability to generate nuclear calcium transients in response to synaptic inputs, and the subsequent induction of expression of plasticity-related and dendritic structure-preserving genes. Insufficient nuclear calcium signaling in CA1 hippocampal neurons and, consequently, reduced expression of the nuclear calcium target gene VEGFD. PMID: 28626015
3. Overexpression of VEGFD causes lymphatic hyperplasia in lung, kidney, and brown adipose tissue. Overexpression of VEGFD in white adipose tissue causes a de novo lymphatic network. PMID: 27342876
4. Vegf-d promotes oedema in response to hyperoxia in mice and support the hypothesis that VEGF-D signalling promotes vascular leak in human hyperoxic acute lung injury (HALI). PMID: 26924464
5. VEGF-D may be beneficial in early-stage tumors since it suppresses the pro-tumorigenic inflammation, while at later stages VEGF-D-induced tumor lymphatics provide a route for metastasis. PMID: 27435926
6. These results suggest that lymph node lymphangiogenesis occurs before metastasis in OSCC. VEGF-A and VEGF-D play critical roles in this process. PMID: 26630663
7. Results provided evidence that IL-7/IL-7R induce VEGF-D upregulation and promote lymphangiogenesis via c-Fos/c-Jun pathway in lung cancer. PMID: 24115038
8. Epidermal keratinocyte proliferation in vitro was not affected by VEGF-C or VEGF-D. PMID: 23695550
9. Neutrophils contribute to lymphangiogenesis primarily by modulating VEGF-A bioavailability and bioactivity and, to a lesser extent, secreting VEGF-D. Neutrophils increased VEGF-A bioavailability and bioactivity via the secretion of MMP9 and heparanase. PMID: 24113869
10. Vegf-d deficiency alters the caliber of initial lymphatics in the dermis leading to reduced functional capacity. PMID: 23439394
11. Vascular endothelial growth factor-C and -D are involved in lymphangiogenesis in mouse unilateral ureteral obstruction. PMID: 22932121
12. VEGF-D has a role in progestin-induced break-through bleeding in thin-walled blood and lymphatic endometrial vessels PMID: 22383980
13. nuclear calcium-VEGFD signaling mediates the effect of neuronal activity on the maintenance of dendritic arbors in the adult hippocampus and is required for cognitive functioning. PMID: 21745642
14. Data show that that OUBC induces profound lymphangiogenesis in the tumor and SLN and substantial lymphatic metastasis to SLN through VEGF-C/D-VEGFR-3 signaling pathway. PMID: 21481239
15. VEGF-D over-expression has differential effects on the uterine vasculature. These effects may facilitate VEGF-D's ability to promote endometrial cancer metastasis and disease progression. PMID: 20615255
16. We investigated the expression of IEGs, including c-fos, fos-B, c-jun and dusp-1 mRNA, in the mouse heart after a once-daily methamphetamine injection for 1day, 2 or 4weeks. PMID: 19828354
17. These results show that VEGF-C/-D together with its receptor VEGFR-3 provides an auto-/paracrine growth and chemotactic system for glial precursors in the developing brain. PMID: 19646499
18. there are unique temporal and spatial expressions of VEGF-D isoforms during lung development which related factors have distinct functions in vascular and lymphatic patterning of the lung PMID: 12112468
19. VEGF-D promotes tumor angiogenesis, lymphangiogenesis and metastatic spread by a paracrine mechanism PMID: 12148568
20. study demonstrated that beta-catenin negative regulation is on theessenger vascular endothelial growth factor-D mRNA 3'-untranslated region PMID: 12920128
21. VEGF-C and VEGF-D are ligands for the integrin alpha9beta1 PMID: 15590642
22. The lack of a profound lymphatic phenotype in Vegf-d-deficient mice suggests that Vegf-d does not play a major role in lymphatic development. PMID: 15743836
23. VEGF-D/VEGFR-3 signaling plays a critical role in osteoblast maturation PMID: 16624815
24. results suggest the presence of lymphatic capillaries throughout the skeletal muscle, and present the localisation of VEGF-C and -D in the muscles. PMID: 16924525
25. in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only PMID: 17242158
26. Diabetes increased the expression of VEGF-D in skeletal muscle. VEGF-D levels were not changed either in healthy or in diabetic muscle after the exercise training. PMID: 17766486
27. The expression of VEGF-D in the marginal portion of tumor significantly associated with lymphatic metastasis and prognosis in patients with pancreatic adenocarcinoma and may induced lymphangiogenesis. PMID: 18061373
28. Expression of VEGF-D is involved in growth and lymphatic spread of HCC. Therefore, VEGF-D might represent a therapeutic target in HCC. PMID: 18338756
29. These results suggest VEGF-C- and VEGF-D-independent functions for VEGFR-3 in the early embryo. PMID: 18519586
30. These data do not support an important role of VEGF-D in (lymph) angiogenesis or in adipose tissue development. PMID: 19022221
31. VEGF-C, -D, and -A derived from the CD11b+/Gr-1+ macrophages and local inflamed tissues play a critical role in promoting antigen clearance and inflammation resolution. PMID: 19346498
32. Long-term expression of VEGF-C and VEGF-D in skeletal muscle results in the generation of new functional blood and lymphatic vessels. PMID: 19443835

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KEGG: mmu:14205

STRING: 10090.ENSMUSP00000033751

UniGene: Mm.297978