||Sus scrofa (Pig)
Myosin heavy chain 7
Myosin heavy chain slow isoform
Short name= MyHC-slow
Myosin heavy chain, cardiac muscle beta isoform
Short name= MyHC-beta
||Store at -20°C, for extended storage, conserve at -20°C or -80°C.
||Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
||Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.