Recombinant Rat Connective tissue growth factor (Ctgf)

1. Findings suggested that hypoxia induced CTGF upregulation in hypoxic pulmonary hypertension (HPH) rat model. CTGF mediated hypoxia-induced regulation of miR-26b and SRF in proliferation of pulmonary arterial smooth muscle cells, which indicated that hypoxia-induced miR-26b inhibition contributed to the pathogenesis of HPH via CTGF. PMID: 28816418
2. Ang II down-regulates KLF15 expression via the AT1 receptor, and KLF15 is likely to inhibit Ang II-induced CTGF expression by repressing the recruitment of the co-activator P/CAF to the CTGF promoter. PMID: 29179208
3. our findings showed that miR-375 binds to 3'-UTR region of Ctgf mRNA, subsequently leading to the decreased expression of Ctgf in the I/R brain. Furthermore, we showed that miR-375/Ctgf-mediated protective effects are associated with p21/PI3K/Akt signaling pathways. PMID: 29187583
4. The blocking of this pathway by its inhibitor LY294002 impaired the proliferative effect of CCN2 on chondrocytes. These results suggested a novel physiological role of CCN2 in the development of condylar cartilage. PMID: 29198711
5. CTGF may be a relevant factor contributing to tubulointerstitial fibrosis in polycystic kidney disease. PMID: 29058957
6. Connective tissue growth factor (CTGF) has been found to be an important downstream mediator of TGF-beta1, and controls pro-fibrotic activities in renal fibrosis. PMID: 27597128
7. the administration of cp-asiCTGF in the rat skin excision wound model efficiently reduced the induction of CTGF and collagens during the wound-healing process. These results suggest that the cp-asiCTGF molecule could be developed into antifibrotic therapeutics such as antiscar drugs PMID: 27427487
8. Overexpression of KLF15 can partially rescue aortic remodeling and aortic dissection formation in animal models by inhibiting CTGF expression. PMID: 26600407
9. Sitagliptin is a better renoprotective than Pioglitazone, probably due to its suppressor effect on CTGF, a key factor mediating diabetic renal injury PMID: 27049870
10. RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix. PMID: 27126736
11. In cultured neonatal cardiac fibroblasts, p63RhoGEF regulated the angiotensin II (Ang II)-dependent RhoA activation, the activation of the serum response factor, and the expression and secretion of CTGF. PMID: 26392029
12. Ctgf stimulates the proliferation, migration and differentiation of lung fibroblasts during paraquat-induced pulmonary fibrosis. PMID: 25815693
13. Over-expression of CTGF from a lentiviral vector increased the expression of Scx and Tnmd as well as tendon proteins type I collagen (ColI) and tenascin-C (Tn-C) in TSCs compared to non-treated control cells. PMID: 25833297
14. Data indicate that connective tissue growth factor (CTGF) small hairpin RNA (pCTGF-shRNA) mediated by polyamidoamine reduced myocardial CTGF expression, suggesting that this system can be used to improve myocardial fibrosis therapy. PMID: 25177951
15. Both the overexpression of CTGF and the loss of podocalyxin reflect renal damage in spontaneously hypertensive rats. CTGF and PCX may be involved in the mechanisms of podocyte injury and apoptosis induced by hypertension PMID: 25003484
16. Our observations suggest a pathological role of CTGF in traumatic brain injury PMID: 25012526
17. These findings indicated that CTGF plays a key role in the pathogenesis of liver fibrosis and lentiviral-mediated CTGF siRNA has the potential to be an effective treatment for liver fibrosis. PMID: 23456538
18. Connective tissue growth factor and beta-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma. PMID: 24839947
19. CTGF is critical in rat pulmonary injury induced by bleomycin PMID: 24083993
20. CTGF mRNA expression increased progressively with the prolongation of Pseudomonas aeruginosa induced COPD. PMID: 23848567
21. Connective tissue growth factor (CTGF/CCN2) is negatively regulated during neuron-glioblastoma interaction. PMID: 23383241
22. Silencing CTGF and TIMP-1 caused decreased secretion of procollagen type-I, procollagen type-I and laminin in rat hepatic stellate cells. PMID: 23207149
23. PPARgamma ligand shows potent inhibitory effect on TGF-beta1-induced CTGF expression in rat hepatic stellate cells. PMID: 19620052
24. this study provides the first evidence for multi-organ regulation of CCN1 and CCN2 in early stages of sepsis, and implies the eruption of inflammatory mediators as a potential mechanism behind the observed CCN1 regulation. PMID: 22334618
25. CTGF is expressed in mast cells in lungs in the development of pulmonary fibrosis. PMID: 22097728
26. Rosiglitazone directly blocks the up-regulation of CTGF in pulmonary arteries of rats suffering from lung fibrosis. PMID: 20684283
27. Baicallin could prevent the up-regulation of CTGF expression in fibrotic lungs of rats receiving bleomycin instillation. PMID: 21170500
28. CTGF and alpha-SMA could play an important role in the development of pulmonary fibrosis caused by paraquat poisoning. PMID: 21126421
29. JNK mediates the expression of CTGF and corneal scarring in corneal wound healing. PMID: 22363806
30. Retinal cellular apoptosis index had a significant positive correlation to the expression of CTGF in diabetic rats. PMID: 21914267
31. When the damaging effects on podocyte structure and function persist chronically, continuous CTGF expression in podocytes is a critical factor that promotes progressive accumulation of glomerular extracellular matrix and glomerulosclerosis. PMID: 21814837
32. CTGF antagonism may offer a novel therapeutic strategy to alleviate BPD and PH in neonates. PMID: 21659659
33. Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor. Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling. PMID: 21576830
34. might play essential role in maintaining periodontal ligament fiber integrity under mechanical stress PMID: 21762408
35. Intraportal vein siRNA injection targeting CTGF could significantly inhibit CTGF gene expression in rats, and thereby attenuate liver fibrosis by decreasing the number of active hepatic stellate cells. PMID: 21138629
36. Upregulation of CTGF pulmonary gene expression after prenatal RA treatment may promote lung growth by promoting alveologenesis in the nitrofen-induced CDH model. PMID: 21258935
37. IL-13 induces a time- and dosage-dependent increase of Connective tissue growth factor PMID: 21804025
38. Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor in failing hearts. PMID: 21382976
39. Recombinant expression, purification, and functional characterisation of connective tissue growth factor and nephroblastoma-overexpressed protein PMID: 21209863
40. In cardiac fibroblasts, Rac1 GTPase mediates upregulation of fibronectin via LOX and CTGF. PMID: 21215756
41. CTGF mRNA expression in NRK52E cells was significantly associated with alpha-SMA mRNA expression. PMID: 20369462
42. plasmid-based shRNA against CTGF attenuated pulmonary vascular remodeling in cigarette smoke-exposed rats PMID: 21295007
43. Simvastatin can decrease the expression levels of CTGF and alpha-SMA in renal tubulointerstitium of rats with diabetic nephropathy. PMID: 20936727
44. Glomerulosclerosis, tubulointerstitial fibrosis, and arterial media hypertrophy lesions of hypertensive nephrosclerosis are all characterized by increased CTGF tissue expression, which is associated with a concomitant increase in CTGF in blood and urine. PMID: 20689330
45. These results suggest that the diabetes-mediated increase in CTGF upregulates VEGF and TGF-beta(2) expression and induces apoptosis in the retina. PMID: 20039857
46. CTGF plays a significant role in the pathological changes of chronic allograft nephropathy after kidney transplantation. PMID: 20979869
47. Upregulation of CTGF is associated with lung metastasis in chondrosarcoma. PMID: 20809981
48. Trimetazidine effectively inhibits myocardial fibrosis, perhaps through the NADPH oxidase-ROS-CTGF signalling pathway. PMID: 20534773
49. Decreasing expression of CTGF in ovary after chorionic gonadotropin treatment was time-dependent. PMID: 18846344
50. The up-regulation of CTGF gene expression may play an important role in the development of pulmonary vascular remodeling in pulmonary hypertension. PMID: 19099753

Show More

Hide All

KEGG: rno:64032

STRING: 10116.ENSRNOP00000020528

UniGene: Rn.17145