Recombinant Rat Desmoglein-4(Dsg4),partial

Code CSB-YP757816RA
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Source Yeast
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Code CSB-EP757816RA
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Source E.coli
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Code CSB-EP757816RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP757816RA
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Source Baculovirus
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Code CSB-MP757816RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Dsg4
Uniprot No. Q6W3B0
Alternative Names Dsg4Desmoglein-4
Species Rattus norvegicus (Rat)
Protein Length Extracellular domain
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity).
Gene References into Functions
  1. show that HOXC13, LEF1 and FOXN1 repress DSG4 transcription and provide in vitro and in vivo evidence correlating the Notch pathway with the activation and/or maintenance of DSG4 expression in the hair follicle. PMID: 19683850
  2. cloning and identification of the rat Dsg4 gene, and identification of a missense mutation in a naturally occurring lanceolate hair (lah) rat mutant PMID: 15081105
  3. A large intragenic deletion encompassing nine exons of the desmoglein 4 gene underlies the skin phenotype in the Iffa Credo "hairless" rat. PMID: 15606503
  4. A spontaneous mutation in dsg4 underlies hypotrichosis in a new lanceolate hair rat model. PMID: 15617564
  5. We identified a homozygous missense mutation in the lanceolate (lah/lah) rat. PMID: 16382669

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Involvement in disease Defects in Dsg4 are the cause of an autosomal recessive phenotype lanceolate hair (lah). Lah rats pups develop only a few short hairs on the head and neck which form a lance head at the tip and disappear within one month. Hair regrows again a few days later, following a 29-day cycle of external growth and loss. Almost complete pelage hair loss occurs by 18 month.
Subcellular Location Cell membrane, Single-pass type I membrane protein, Cell junction, desmosome
Database Links

KEGG: rno:291754

STRING: 10116.ENSRNOP00000031941

UniGene: Rn.122657

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