Recombinant Rat Dihydropyrimidinase-related protein 2 (Dpysl2)

1. The results of the present study suggested that TLR4 may promote the phosphorylation of CRMP2 via the activation of ROCKII in MCAO rats, which further characterizes the pathological mechanism of TLR4 in stroke, and that modulation of TLR4 could be a potential target to limit secondary poststroke brain damage. PMID: 29749502
2. The cytosolic regulatory protein collapsin response mediator protein 2 (CRMP2) regulates activity of voltage-gated calcium (specifically N-type or CaV2.2) and voltage-gated sodium channels PMID: 28809766
3. -overexpression effectively protected the proximal axon from fragmentation within 6 hours after crush. Finally, a proteomic analysis of the optic nerve was performed at 6 hours after crush, which identified further proteins regulated during acute axonal d PMID: 27845394
4. CRMP2 expression was significantly upregulated, particularly in the ruptured site of Achilles tendon tissues derived from animals in the mobilization group compared with the immobilization group (0.32+/-0.00 vs. 0.08+/-0.00; P<0.05). Active mobilization may promote Achilles tendon healing via upregulation of CRMP2 protein expression. PMID: 28677754
5. cross-talk between distinct CRMP2 posttranslational modifications is a key factor in determining NaV1.7 trafficking and localization PMID: 27940916
6. Results indicate that activation of the CDK5/CRMP2 pathway may mediate sevoflurane-induced dendritic development abnormalities in the cortical neurons. The physiological significance of these findings remains to be determined. PMID: 28445771
7. The results of this study suggested that the neuroplasticity effect of BMSCs on cerebral ischemia may be associated with the phosphorylated modulation of CRMP2. PMID: 27765673
8. Data suggest collapsin response mediator proteins (CRMP) CRMP2 and CRMP4 form complexes to bridge microtubules and actin and work cooperatively to regulate growth cone development and axonal elongation. PMID: 26064693
9. The present findings demonstrated that the downregulation of genes such as Dpysl2 and Dypsl3 in a rat model of prenatal stress may affect subsequent behavioral changes PMID: 25847191
10. The CRMP2 deSUMOylation by SUMO proteases SENP1 and SENP2 normalized calcium influx to those in the CRMP2AAA mutant. PMID: 23510938
11. CRMP2 interacts with NCX and NMDAR and TAT-CBD3 protects against glutamate-induced Ca(2+) dysregulation most likely via suppression of both NMDAR and NCX activities PMID: 24474686
12. CRMP-2-dependent regulation of ROCK II activity is mediated through interaction of the CRMP-2L N terminus with the ROCK II catalytic domain as well as by GSK3-dependent phosphorylation of CRMP-2. PMID: 24036111
13. RGMa inhibits axon growth by phosphorylating CRMP-2 via both Rho-kinase and GSK-3beta signaling pathways. PMID: 23275173
14. Disruption of NMDA receptor-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model PMID: 22373559
15. CRMP2B and ARPC5 may participate in CNS injury mediated by hypothyroidism by inducing neurite outgrowth inhibition and cytoskeletal protein disorganization. PMID: 23459330
16. a new insight into CRMP-2 as a controller of myosin II-mediated cellular functions through the inhibition of ROCK II in nonneuronal cells PMID: 22431514
17. HCNP-pp, in association with unphosphorylated and/or pSer522-CRMP-2, plays an important role in presynaptic function in the mature hippocampus. PMID: 23276635
18. Cdk5-phosphorylated CRMP-2 had increased association with CaV2.2. PMID: 23022559
19. Found that the Akt/glycogen synthase kinase-3beta /collapsin response mediator protein 2 pathway mediates axonal injury in neonatal rat brain after hypoxic-ischemia. PMID: 22554777
20. These findings suggest, for the first time, that lacosamide's mode of action involves interactions with CRMP2 to inhibit posttraumatic axon sprouting. PMID: 22433297
21. These findings suggest that HCNP-pp, in association with CRMP-2, plays an important role in presynaptic function in the hippocampus PMID: 22542739
22. findings suggest a major role of phosphorylated CRMP-2 as a mechanism involved in process retraction induced by reactive oxygen species PMID: 22443207
23. Activated CRMP2 plays an important role in neuronal plasticity in periventricular leukomalacia in 3-day-old rats. PMID: 21333637
24. the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex. PMID: 21829088
25. Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP2). PMID: 21832084
26. PIPP and CRMP2 exert opposing roles in promoting axon selection and neurite elongation and the complex between these proteins serves to regulate the localization of effectors that promote neurite extension. PMID: 21550974
27. CRMP-2 expression increased in the course of neurite growth and the fact that permanently high CRMP-2 expression interferes with neurite outgrowth; high expression levels of CRMP-2 inhibit the initiation of neurite outgrowth PMID: 20453694
28. Results identify key CRMP-2 residues that can coordinate LCM binding thus making it more effective on its primary clinical target. PMID: 20538611
29. Hippocampal coexpression of wild-type (wt)CRMP2 and protein phosphatase 2A (PP2A) increases axon length compared with wtPP2A alone. PMID: 20220019
30. CRMP-2 regulates axonal growth and branching as a partner of the tubulin heterodimer PMID: 12134159
31. The present study suggests that CRMP-2 has potent neurite elongation activity in nerve regeneration in vivo PMID: 12887701
32. Inhibition of CRMP-2 stopped endocytosis of L1 at axonal growth cones and suppressed axon growth, suggesting that CRMP-2 is involved in polarized Numb-mediated endocytosis of proteins such as L1. PMID: 12942088
33. These results indicate that the CRMP-2/Kinesin-1 complex regulates soluble tubulin transport to the distal part of the growing axon. PMID: 15935053
34. collapsin response mediator protein-2 is an important candidate controlling ischemic stroke PMID: 16189471
35. CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation PMID: 16260607
36. Taken together, these results suggest that Ras plays critical roles in establishing neuronal polarity upstream of the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway and mitogen-activated protein kinase cascade. PMID: 16343426
37. collapsin response mediator protein-2 PMID: 17051644
38. association of neurofibromin and CRMP-2 is essential for neuronal cell differentiation PMID: 18218617
39. Since both neurofibromin and CRMP proteins are involved in proliferation and axonal morphogenesis, these results suggest that the interaction with CRMPs contributes to the function of neurofibromin in tumorigenesis and neuronal morphogenesis. PMID: 18313395
40. post-transcriptional processing of CRMP2 together with its nuclear localization may be an important key in the regulation of neurite outgrowth in brain development PMID: 18332147
41. relative resistance to phosphatases might be a common feature of Cdk5 substrates and could contribute to the hyperphosphorylation of CRMP2 and Tau observed in Alzheimer disease PMID: 18460467
42. Data suggest that collapsin response mediator protein-2 (CRMP-2) is a novel calmodulin-binding protein and that CaM binding may play an important role in regulating CRMP-2 functions. PMID: 19151921
43. Upregulation of Dpysl2 and Spna2 expression in hypertrophic cells in the penumbra regions of cortex and striatum of stroke brain indicates an early neuronal defense mechanism involving active neuronal repair, regeneration and development. PMID: 19524114
44. Local translation of CRMP2 and Tau, regulated by mTOR-p70S6K, is critical for the specification of neuronal polarity. PMID: 19648118
45. CRMP-2 and Cav2.2 interaction modulates Ca(2+) influx into nerve terminals. PMID: 19755421

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KEGG: rno:25416

STRING: 10116.ENSRNOP00000012996

UniGene: Rn.2889