Recombinant Rat Methyl-CpG-binding protein 2 (Mecp2)

1. MeCP2 directly binds to MBP, PLP, and BDNF promoter in oligodendrocytes. MeCP2 differentially regulates the myelin gene expression in oligodendrocytes and C6 glioma. PMID: 29992497
2. These data reveal a functional role of miR-218 and its target, MeCP2, in the regulation of heroin-induced behavioral plasticity. PMID: 28074855
3. in adjuvant arthritis fibroblast-like synoviocytes, MeCP2 mediates hypermethylation of PTCH1 gene and decreases the expression of PTCH1 protein, thus activating Hedgehog signaling pathway and increasing secretion of IL-6 and TNF-alpha. PMID: 28573530
4. Motor, somatosensory, viscerosensory and metabolic impairments in a heterozygous Mecp2-deficient female rat model of Rett Syndrome. PMID: 29286317
5. site-specific methylation and MeCP2 are required for maintenance of basal levels of CRH gene expression. PMID: 28655627
6. This study showed that epigenetic regulation of gene expression by MeCP2 may differentially influence the motivational effects of Methamphetamine and natural reinforcement. PMID: 27312406
7. these findings demonstrate that the Mecp2 rat model is a complementary tool with unique features for the study of Rett syndrome and highlight the potential benefit of cross-species analyses in identifying potential disease-relevant preclinical outcome measures PMID: 27365498
8. MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats PMID: 27329765
9. work suggests that a feedback regulatory mechanism involving both miR-130a and MeCP2 may serve to ensure their appropriate expression and function in neural development. PMID: 27245166
10. This study demonstrated that the MeCP2 and diverse pMeCP2s have distinct features of spatio-temporal expression in the rat brain, and that the precise levels of MeCP2 in the postnatal period are vital to cerebellar neural cell development. PMID: 27995568
11. We demonstrated that MeCP2 may negatively control the acetylation of alpha-tubulin through HDAC6 in cardiac fibroblast proliferation and fibrosis PMID: 26975406
12. MeCP2 acts as a key regulator of pathological cardiac fibrosis, promotes cardiac fibroblasts proliferation and fibrosis by down-regulation of DUSP5. PMID: 26511729
13. DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2 PMID: 26093272
14. homeostatic interactions between MeCP2 and miR132 may regulate hippocampal BDNF levels, which may have a role in the pathogenesis of MDD. PMID: 26239616
15. Results together reveal an important role of MeCP2 SUMOylation in social interaction, memory and synaptic plasticity, and that abnormal MeCP2 SUMOylation is implicated in Rett syndrome. PMID: 26842955
16. MeCP2 knockdown in cultured oligodendrocytes increased myelin genes expression. PMID: 26140854
17. induction of miR-132/212 following bladder outlet obstruction: association with MeCP2 repression and cell viability PMID: 25617893
18. Results show that overexpression of VEGF enhances accumulation of pS292 MeCP2 in reactive astrocytes in ischemic-injured rat striatum, implicating a pS292 MeCP2-related epigenetic role of exogenous VEGF in reactive astrocytes following cerebral ischemia PMID: 25511996
19. A long-lasting increase in MeCP2 expression was found throughout the striatum of maternally deprived rats compared to controls. PMID: 23980619
20. Results suggest that fetal alcohol programming of POMC gene may involve recruitment of MeCP2 on to the methylated promoter of the POMC gene to suppress POMC transcript levels and contribute to hypothalamic-pituitary-adrenal axis dysregulation. PMID: 25409090
21. Passive and voluntary cocaine administration positively regulate Mecp2 and negatively PP1Cbeta protein expression in reward-related brain structures; the two proteins were induced by food operant conditioning, no effect when food was passively delivered PMID: 24936739
22. MeCp2 direct repression of GluA1 function in amygdala is a likely mechanism for morphine-seeking behavior maintained by long-lasting affective pain after morphine withdrawal. PMID: 25716866
23. These data contribute to the idea that the role of MeCP2 differs in the developing male versus female brain. Further elucidating the regulation and function of GFAP can contribute to our understanding of MeCP2 function. PMID: 24269336
24. data demonstrate that PP1Cbeta is a direct MeCP2-target gene in vivo. PMID: 23688924
25. The SUMOylation of MeCP2 at K223 is a critical switch for transcriptional repression and plays a crucial function in regulating synaptic development in the central nervous system. PMID: 24188180
26. MeCP2 binding triggers the loss of HP1gamma at the chromosomal domain and an increased HP1gamma mobility. PMID: 23935992
27. MeCP2 controls PTCH1 expression during Hepatic stellate cell activation and proliferation. PMID: 23333245
28. MeCP2 and DNA methylation may provide molecular mechanisms for canonical Wnt pathway activation in Rheumatoid arthritis. PMID: 23200852
29. Results suggest that changes in chromatin compaction, regulated by the binding of MeCP2 complexes to methylated DNA, are involved in the modulation of gene expression in the superficial dorsal horn and dorsal root ganglia during persistent pain states. PMID: 22369085
30. MeCP2 is a multifuncitonal protein with a role in mRNA biogenesis, using an additional mechanism for Rett syndrome pathophysiology. PMID: 21070191
31. We demonstrated the presence of MeCP2 mRNA, protein, and miR132 in the rat lung throughout alveolarization. PMID: 21425435
32. MeCP2 and DNA methylation may provide molecular mechanisms for perpetuated fibroblast activation and fibrogenesis in the liver PMID: 22056649
33. MeCP2 is essential for myofibroblast differentiation and pulmonary fibrosis PMID: 21435439
34. A very clear presence of MeCP2 protein is found in oligodendrocyte progenitors isolated from neonatal rat brain. PMID: 20697302
35. MeCP2 regulates cocaine intake through homeostatic interactions with miR-212 to control the effects of cocaine on striatal BDNF levels, these interactions may be important in regulating vulnerability to cocaine addiction PMID: 20711185
36. Cdkl5 is a MeCP2-repressed target gene providing a link between genes the mutation of which generates overlapping symptoms: DNA methylation changes are a potential mechanism participating in the long-term plasticity triggered by pharmacological agents PMID: 20211261
37. MeCP2 associates with DNA methyltransferase /Dnmt1/ in order to perform maintenance DNA methylation in vivo PMID: 12473678
38. MeCP2 plays arole in neuronal maturation, and/or the maintence of neurons in a differentiated state. PMID: 12605461
39. MeCP2 protein expression has a role in the initiation and/or progression of hepatic cancer induced by methyl deficiency PMID: 12949043
40. findings show that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene PMID: 14593183
41. MeCP2 expression is correlated with synaptogenesis is consistent with the hypothesis that Rett Syndrome is caused by defects in the formation or maintenance of synapses. PMID: 14751287
42. Highest MeCP2 expression was in olfactory bulb and frontal cortex. Little was detected in caudate-putamen, septum and hippocampus. Except in the olfactive nuclei, very few cells showed detectable MeCP2 at birth. PMID: 15006690
43. MeCP2 is an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex PMID: 15322089
44. MeCP2 and DNA methylation exert epigenetic control over hepatic wound healing and fibrogenesis. PMID: 16763620
45. By triggering MeCP2 phosphorylation, neuronal activity regulates a program of gene expression that mediates CNS maturation and distruption of this process in individuals with mutations in MeCP2 may underlie the neural-specific pathology of RTT. PMID: 17046689
46. Phosphorylation of MeCP2 regulates activity-dependent gene transcription; MeCP2 is found to be phosphorylated in dorsal horn cells after peripheral inflammation. PMID: 17553988
47. Results show that Bdnf mRNA expression decreased in the hippocampus, supporting the hypothesis that Bdnf may be a target gene of MeCP2 in the CNS. PMID: 18396005
48. Report that clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. PMID: 18550052
49. Mecp2 may have an overlooked role in the organization of sexually dimorphic behaviors and that male juvenile behavior is particularly sensitive to Mecp2 disruption during this period of development. PMID: 18614683
50. These data indicate that DNA methylation as well as subsequent MeCP2 association mediates neuronal activity-dependent regulation of NR2B expressions. PMID: 18952054

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KEGG: rno:29386

STRING: 10116.ENSRNOP00000053166

UniGene: Rn.38416