Recombinant Rat Neuronal acetylcholine receptor subunit alpha-4 (Chrna4), partial

1. the mechanism of interaction between [Upsilon4E]GID and the agonist binding pockets of the alpha4beta2 and the halpha7 receptors, and to estimate their relative binding affinities, was investigated. PMID: 27721068
2. findings indicate that alterations in expression of the alpha4beta2 subtype of nAChR may be involved in the molecular mechanism(s) underlying the cognitive deficit associated with vascular dementia PMID: 26858154
3. Data indicate that compounds showed favorable subtype selectivity for beta2*-nAChRs over beta4*-nAChRs. PMID: 23734673
4. Artificial food colors and additives led to a decrease in the expressions of nAChR alpha4 subunits in male rats. PMID: 23429044
5. Data suggest that alpha4 beta2 nicotinic receptors (Chrna4; Chrnb2) are involved in tolerance to DOPA exhibited as drug-induced dyskinesias in late stages of Parkinson's disease. PMID: 23583932
6. The azabicyclic alcohol was found to compete with MTSEA between residues 6' & 13' in a state-dependent manner, but the reactive probe only bonded with 13' in the open state, suggesting that the 13' position is the dominant binding site. PMID: 22778816
7. Data indicate that functional alpha4/beta2 nicotinic acetylcholine receptors (alpha4beta2 nAChR) plays a role in proliferation and differentiation fate into a neuronal lineage in neural progenitors of developing neocortex. PMID: 23056257
8. nAChR alpha4 subtype contributes to the cholinergic nicotinic regulation of catecholamine signaling in the carotid body system. PMID: 22127290
9. Our results identify a novel palmitoylation site on cysteine 273 in the M1-M2 loop of the alpha4 nAChR and determine that cysteines in both intracellular loops are regulatory factors in total and cell surface protein expression of the alpha4beta2 nAChR. PMID: 22593584
10. The number of functional alpha4beta2 heteromeric neuronal nicotinic receptors is decreased in the brains of rats with severe renal failure. PMID: 22510484
11. Nicotine-induced upregulation of the nAChR alpha4beta2 receptor demonstrates that at least two different kinetic mechanisms underlie multiple processes occurring at different rates in rat cortical neurons in real time. PMID: 22323734
12. the lower alpha4beta2 nAChR number in spontaneously hypertensive rat compared with WKY may be a consequence of dysfunctional post-transcriptional regulation of nAChRs PMID: 21824140
13. central alpha4beta2 nicotinic acetylcholine receptors that enable a provoking effect of endogenous acetylcholine play a critical role in impulsive action PMID: 20639140
14. Data show that a hydrogen bond is functionally significant in the alpha4beta2 neuronal nAChR. PMID: 20616056
15. Suggest a critical role for alpha4beta2 nAChRs in the infralimbic cortex in mediating the effects of nicotine on impulsive-like actions. PMID: 20238211
16. Electrophysiological properties of Chrna4 indicate that Ser-284 plays an important role in the gating of nAChR along with Thr-276 and Ser-280 and suggest that the mutation at Ser-284 reduces nAChR activity similarly to other mutations of alpha 4 subunit. PMID: 11904236
17. a role for alpha4beta2-like AChRs, but not alpha7 AChRs, in rapid excitatory transmission between alpha-motor neurons and Renshaw cells in rat spinal cord. PMID: 12037212
18. surface expression levels and functional properties modulated by visinin-like protein-1 in response to changes in calcium levels PMID: 12202488
19. Ca2+ modulation may prevent presynaptic alpha4beta2 nAChRs from overstimulating glutamate release at central excitatory synapses during bouts of synchronous, repetitive activity; could trigger seizures PMID: 12754307
20. the alpha4 subunit of the nicotinic receptor is positioned to mediate the effects of acetylcholine widely across many, if not all, monoaminergic neurons in the brainstem PMID: 12774304
21. At least two different affinity sites for acetylcholine. Sensitivity to block of alpha4beta2 channels by dihydro-beta-erythroidine was higher than that for alpha2beta2. Current-voltage for alpha2beta2 more strongly rectified than for alpha4beta2. PMID: 15026122
22. Nicotinic acetylcholine receptor alpha 4 subunit is localized in virtually all nociceptive neurons that are identified by immunoreactivity for the vanilloid receptor TRPV-1. PMID: 15296793
23. We propose that the enhanced expression of alpha4 nAChR by astrocytes stimulated directly by nanomolar concentrations of Abeta(1-42) might be related to ongoing defensive or compensative mechanisms. PMID: 15955596
24. Mutation of F350, L351, L357, & L358 to alanine in the alpha4 AChR subunit attenuates cell surface expression of mutant alpha4beta2 AChRs. There may be a cooperative or regulatory role for the alpha4 AChR subunit in ER export. PMID: 16014729
25. close spatial apposition of full-length P2X2 and alpha4beta2 channels within 100 nm of the plasma membrane of living cells PMID: 16033901
26. analysis of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors PMID: 16407231
27. alpha4beta2 nicotinic acetylcholine receptors may play a role in ethanol-seeking behaviors in animals chronically exposed to ethanol PMID: 17626178
28. alpha-4 nicotinic acetylcholine receptors by GABAergic neurons of rostral ventral medulla and caudal pons. PMID: 17950703
29. alpha4 containing receptors are positioned to influence 5-HT neurons directly at postsynaptic sites. PMID: 18403129
30. data indicate that alpha6beta2(*) nAChR-evoked dopamine release in nicotine-treated rats is mediated by the alpha6(nonalpha4)beta2(*) nAChR subtype PMID: 18583454
31. Results show that amyloid beta protein induces suppression of long-term potentiation in rat hippocampus, and that this suppression is mediated through alpha4beta2 nicotinic acetylcholine receptors. PMID: 18602971
32. Phosphorylation at multiple consensus sites in the alpha4 subunit could play a remarkable role on the regulation of the functional expression of the alpha4beta2 nAChR. PMID: 18818999
33. Nicotinic alpha4 beta2 receptors partly mediate brainstem autonomic dysfunction evoked by the inhaled anesthetic isoflurane. PMID: 19095841
34. Neurexin-1beta targets AChR alpha4 and AChR beta2 to presynaptic terminals. PMID: 19567877

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KEGG: rno:25590

STRING: 10116.ENSRNOP00000009041

UniGene: Rn.9697