Recombinant Human Interleukin-1 receptor type 2(IL1R2)

Code CSB-CF011622HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P27930
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence FTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLAFLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK
Source in vitro E.coli expression system
Gene Names IL1R2
Protein Names Recommended name: Interleukin-1 receptor type 2 Short name= IL-1R-2 Short name= IL-1RT-2 Short name= IL-1RT2 Alternative name(s): CD121 antigen-like family member B CDw121b IL-1 type II receptor Interleukin-1 receptor beta Short name=
Expression Region 14-398
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Subcellular Location Isoform Short: Secreted, SUBCELLULAR LOCATION: Isoform Long: Cell membrane, Single-pass type I membrane protein
Protein Families Interleukin-1 receptor family
Database Links

HGNC: 5994

OMIM: 147811

KEGG: hsa:7850

STRING: 9606.ENSP00000330959

UniGene: Hs.25333

Pathway Hematopoietic cell lineage

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