IL1R2

IL1R2 encodes the Interleukin-1 receptor type II protein, also commonly known as CD121b. It functions as a decoy receptor for interleukin-1 (IL-1), binding to IL-1 without transducing a signal, thus regulating the activity of IL-1. This protein is involved in the IL-1 signaling pathway, which is crucial for immune and inflammatory responses.
Dysregulation of IL1R2 has been associated with various diseases, including rheumatoid arthritis and certain types of cancer. In drug development, targeting IL1R2 is being explored as a potential strategy to modulate the IL-1 pathway and treat these related diseases, but more research is needed to fully realize its therapeutic potential.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA.Immobilized Human IL1B(CSB-MP011614HU) at 5 μg/ml can bind Human IL1R2. The EC₅₀ is 89.65-100.5 ng/mL.

The purity of IL1R2 was greater than 90% as determined by SEC-HPLC

IL1R2 Antibody (CSB-PA011622ESR1HU)

Validated Data

Western blot
All lanes: Interleukin-1 receptor type 2 antibody at 3μg/ml + Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 46, 34 kDa
Observed band size: 46 kDa

The following IL1R2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

IL1R2 Antibodies

IL1R2 Proteins

IL1R2 ELISA Kits

IL1R2 Antibodies

IL1R2 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA011622ESR1HU	IL1R2 Antibody	Human, Mouse	ELISA, WB
CSB-PA005852	IL1R2 Antibody	Human	WB, ELISA
CSB-PA247988	IL1R2 Antibody	Human	ELISA,IHC

IL1R2 Proteins

IL1R2 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

Code	Product Name	Source
CSB-YP644928DSU CSB-EP644928DSU CSB-BP644928DSU CSB-MP644928DSU CSB-EP644928DSU-B	Recombinant Chlorocebus aethiops Interleukin-1 receptor type 2 (IL1R2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL1R2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF011622HU	Recombinant Human Interleukin-1 receptor type 2 (IL1R2)	in vitro E.coli expression system
CSB-YP011622HU1 CSB-EP011622HU1 CSB-BP011622HU1 CSB-EP011622HU1-B	Recombinant Human Interleukin-1 receptor type 2 (IL1R2), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP011622HU1	Recombinant Human Interleukin-1 receptor type 2 (IL1R2), partial (Active)	Mammalian cell

IL1R2 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF011622MO	Recombinant Mouse Interleukin-1 receptor type 2 (Il1r2)	in vitro E.coli expression system
CSB-YP011622MO1 CSB-EP011622MO1 CSB-BP011622MO1 CSB-MP011622MO1 CSB-EP011622MO1-B	Recombinant Mouse Interleukin-1 receptor type 2 (Il1r2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL1R2 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF011622RA	Recombinant Rat Interleukin-1 receptor type 2 (Il1r2)	in vitro E.coli expression system
CSB-YP011622RA1 CSB-EP011622RA1 CSB-BP011622RA1 CSB-MP011622RA1 CSB-EP011622RA1-B	Recombinant Rat Interleukin-1 receptor type 2 (Il1r2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL1R2 ELISA Kit

IL1R2 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E04612h	Human soluble interleukin-1 receptor Ⅱ,IL-1sRⅡ ELISA kit	serum, plasma, tissue homogenates	19.5 pg/mL

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IL1R2

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