TRIM38 Antibody

Code CSB-PA275171
Size US$297
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  • Western blot analysis of extracts from RAW264.7 cells and LOVO cells, using TRIM38 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRIM38 Polyclonal antibody
Uniprot No.
Target Names
TRIM38
Alternative Names
TRIM38 antibody; RNF15 antibody; RORET antibody; E3 ubiquitin-protein ligase TRIM38 antibody; EC 2.3.2.27 antibody; RING finger protein 15 antibody; RING-type E3 ubiquitin transferase TRIM38 antibody; Tripartite motif-containing protein 38 antibody; Zinc finger protein RoRet antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human TRIM38.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.
Gene References into Functions
  1. Data suggest that mRNA/protein levels of NLRP6 are down-regulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients; NLRP6 provides docking site to facilitate interaction between TAB2/3 and TRIM38 in RA synoviocytes in response to TNFalpha. (NLRP6 = ; TAB2/3 = transforming growth factor-b-activated kinase 1-binding protein 2/3; TRIM38 = tripartite motif 38) PMID: 28295271
  2. TRIM38 may act as a novel negative regulator for TLR3-mediated type I interferon signaling by targeting TRIF for degradation PMID: 23056470
  3. NF-kappaB is activated in response to TRIM38. PMID: 21789858
  4. Enterovirus 71 infection induces degradation of TRIM38. PMID: 21306652
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 10059

KEGG: hsa:10475

STRING: 9606.ENSP00000230099

UniGene: Hs.584851

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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