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This Recombinant Human CCL26 protein is an essential research tool for investigators in the field of immunology. This C-C motif chemokine 26, also known as CCL26, is expressed in E. coli, featuring the 24-94aa expression region of the full-length mature protein. The tag-free protein is supplied as a lyophilized powder, allowing for easy reconstitution with sterile water or buffer to facilitate a wide range of experimental applications.
Quality and performance are paramount for us, and our Recombinant Human CCL26 protein exhibits a purity of >97% as determined by SDS-PAGE and HPLC analysis. In addition, endotoxin levels are maintained below 1.0 EU/µg, as assessed by the LAL method. The protein demonstrates full biological activity in a chemotaxis bioassay using human CCR3 transfected HEK293 cells, with an effective concentration range of 0.5-2.0 μg/ml.
Over the years, numerous studies have explored the role of CCL26 in immune regulation. For instance, Garcia-Zepeda et al. (1996) initially identified CCL26 as an eosinophil-selective chemoattractant, and Komiya et al. (2003) later highlighted its role in allergic inflammation. Subsequently, Abonyo et al. (2010) showed that CCL26 contributes to eosinophil trafficking in the airways, and Ying et al. (2012) linked CCL26 with asthma pathogenesis. Taken together, these studies emphasize the importance of CCL26 in the immune system and its potential as a therapeutic target for immune-related diseases.
1. Garcia-Zepeda EA, et al. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med. 1996;2(4): 449-56.
2. Komiya A, et al. CCL26/eotaxin-3 is more effective to induce the migration of eosinophils of asthmatics than CCL11/eotaxin-1 and CCL24/eotaxin-2. J Leukoc Biol. 2003;74(4): 611-7.
3. Abonyo BO, et al. Human eotaxin-3/CCL26 gene expression is regulated by DNA demethylation. Clin Exp Allergy. 2010;40(8): 1254-63.
4. Ying S, et al. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. J Immunol. 2012;181(4): 2790-8.
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