Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FXYD3 Polyclonal antibody

Uniprot No.

Q14802

Target Names

FXYD3

Alternative Names

Chloride conductance inducer protein Mat 8 antibody; Chloride conductance inducer protein Mat-8 antibody; FXYD domain containing ion transport regulator 3 antibody; FXYD domain-containing ion transport regulator 3 antibody; Fxyd3 antibody; FXYD3_HUMAN antibody; Mammary tumor 8 kDa protein antibody; MAT-8 antibody; MAT8 antibody; MGC111076 antibody; Phospholemman like antibody; Phospholemman-like antibody; PLML antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens

Immunogen

Recombinant Homo sapiens FXYD3 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (12-14 weeks)

Target Background

Function

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes.; Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials.; Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials.

Gene References into Functions

Suppression of FXYD3 in MCF-7. PMID: 26740212
All three markers correlated significantly with regional lymph node metastasis: FXYD3 (p = 0.0110), S100A11 (p = 0.0071), and GSTM3 (p = 0.0173) in colon cancer lymphatic metastasis. PMID: 22430872
ExoS facilitates P. aeruginosa penetration through the intestinal epithelial barrier by binding to FXYD3 and thereby impairing the defense function of tight junctions against bacterial penetration. PMID: 20805335
Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma. PMID: 20364041
FXYD3 expression is related to several biological variables including ras, p53, legumain and PCNA, and may be involved in the development of the relatively early stages of colorectal cancers PMID: 19955746
Upregulation of FXYD3 is associated with glioma. PMID: 20112499
inactivation of FXYD3 through a gene mutation or unknown mechanism could be one cause of the atypical shapes of cancer cells and play a potential role in the progression of lung cancer. PMID: 19893046
Results indicate that the human MAT-8 gene contains the potential to serve as a prostate cancer expression marker and that MAT-8 plays an important role in cellular growth of prostate carcinomas. PMID: 14654946
overexpression of FXYD3 in pancreatic cancer may contribute to the proliferative activity of this malignancy PMID: 16003754
analysis of two human FXYD3 isoforms that are differentially expressed in differentiated and non-differentiated cells with different functional properties PMID: 17077088
FXYD3 interacts with Na(+)-K(+)-Exchanging ATPase in colorectal neoplasms. PMID: 17409496
structures of the FXYD proteins (with emphasis on 1-4), as well as their dynamics and their associations with the lipid PMID: 18000745
FXYD3 silencing prevents proper regulation of Na,K-ATPase, which leads to perturbation of cellular Na+ and K+ homeostasis and changes in the expression of Na,K-ATPase isozymes, whose functional properties are incompatible with cell differentiation. PMID: 19109419
FXYD3a protein is highly expressed in breast cancers, and responsible for cancer cell proliferation. PMID: 19571376

Hide All

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

FXYD family

Tissue Specificity

Isoform 1: Expressed mainly in differentiated cells (at protein level). Isoform 2: Expressed mainly in undifferentiated cells (at protein level).

Database Links

HGNC: 4027

OMIM: 604996

KEGG: hsa:5349

STRING: 9606.ENSP00000389770

UniGene: Hs.301350

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FXYD3 Antibody

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