gld-1 Antibody

Code CSB-PA623141XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans gld-1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
gld-1 antibody; T23G11.3Female germline-specific tumor suppressor gld-1 antibody; Defective in germ line development protein 1 antibody
Raised in
Species Reactivity
Caenorhabditis elegans
Recombinant Caenorhabditis elegans gld-1 protein
Immunogen Species
Caenorhabditis elegans
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence. Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA. Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA. Binds sequences in the 3'-UTR region of tra-2 mRNA. Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline. Represses translation of the vacuolar ATPase component vha-13 in the distal gonad. Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation. By regulating cye-1 expression, prevents entry into mitosis in meiotic germline cells.
Gene References into Functions
  1. GLD-1 expression and degradation during oocyte meiotic progression. PMID: 29496961
  2. glp-1 transcriptional targets lst-1 and sygl-1 are individually required for GLD-1 repression in stem cells; regulation of GLD-1 levels and pattern appears regional in the proliferative zone PMID: 26757772
  3. Gld-1; puf-8 double-mutant germ cells begin to express the meiotic marker HIM-3, lose P granules, and form the sperm-specific membranous organelle, which are characteristics of developing spermatocytes. PMID: 26068572
  4. We examine GLD-1-binding motifs among targets conserved in C. elegans and C. briggsae and find that most, but not all, display evidence of shared ancestral binding sites. PMID: 25502909
  5. The study demonstrates that the QUA2 domain distinguishes GLD-1 from other members of the STAR family and contributes more generally to the modulation of RNA-binding affinity and specificity of KH domain containing proteins. PMID: 24838563
  6. Results show the RNA-binding protein GLD-1 in C. elegans affects multiple microRNA pathways and interacts with proteins required for microRNA function. PMID: 24258276
  7. Our results demonstrate that both proteins recognize the glp-1 3' untranslated region (UTR) through adjacent, overlapping binding sites and that POS-1 binding excludes GLD-1 binding PMID: 23034181
  8. we observed that GLD-1 has a widespread role in repressing translation but, importantly, also in stabilizing a sub-population of its mRNA targets PMID: 22693456
  9. Data indicate that the translational repression is mediated by GLD-1, an RNA-binding protein also required for oocyte meiosis and differentiation. PMID: 22106259
  10. GLD-1 is crucial for the CYE-1/CDK-2 mitosis/meiosis control PMID: 21455289
  11. A comprehensive analysis of GLD-1 interaction with mRNA, providing a list of potential GLD-1 targets as well as a quantitative description of the determinants underlying mRNA recognition by GLD-1. PMID: 21169991
  12. GLD-1 binds to TGE RNA and regulates tra-2 translation. PMID: 20573244
  13. Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation PMID: 20223220
  14. Low GLD-1 levels allow proliferation and increased levels promote meiotic entry. PMID: 14660440
  15. identified the consensus STAR-binding element (SBE) required for specific mRNA recognition by GLD-1, a key regulator of germline development PMID: 14718919
  16. Analysis of several mRNA targets containing premature stop codons suggests that in translation repression, GLD-1 either represses ribosome assembly on the target mRNA, or subsequent ribosome elongation to the premature stop codon. PMID: 15105376
  17. GLD-1 mediates a developmental switch in the translational control of C. elegans PAL-1 PMID: 15201219
  18. The RNA binding affinity of 11 mutant GLD-1 proteins was measured, and their binding specificity was assessed with a series of TGE RNAs containing natural or modified nucleotides PMID: 15663930
  19. GLD-1 mediates its repressive effect by directly binding to the 3'UTR of cep-1/p53 mRNA and repressing its translation. PMID: 15707894

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Tissue Specificity
Expressed in proximal and distal oocytes in female worms but is eliminated from proximal oocytes following mating.
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