gld-1 Antibody

1. GLD-1 expression and degradation during oocyte meiotic progression. PMID: 29496961
2. glp-1 transcriptional targets lst-1 and sygl-1 are individually required for GLD-1 repression in stem cells; regulation of GLD-1 levels and pattern appears regional in the proliferative zone PMID: 26757772
3. Gld-1; puf-8 double-mutant germ cells begin to express the meiotic marker HIM-3, lose P granules, and form the sperm-specific membranous organelle, which are characteristics of developing spermatocytes. PMID: 26068572
4. We examine GLD-1-binding motifs among targets conserved in C. elegans and C. briggsae and find that most, but not all, display evidence of shared ancestral binding sites. PMID: 25502909
5. The study demonstrates that the QUA2 domain distinguishes GLD-1 from other members of the STAR family and contributes more generally to the modulation of RNA-binding affinity and specificity of KH domain containing proteins. PMID: 24838563
6. Results show the RNA-binding protein GLD-1 in C. elegans affects multiple microRNA pathways and interacts with proteins required for microRNA function. PMID: 24258276
7. Our results demonstrate that both proteins recognize the glp-1 3' untranslated region (UTR) through adjacent, overlapping binding sites and that POS-1 binding excludes GLD-1 binding PMID: 23034181
8. we observed that GLD-1 has a widespread role in repressing translation but, importantly, also in stabilizing a sub-population of its mRNA targets PMID: 22693456
9. Data indicate that the translational repression is mediated by GLD-1, an RNA-binding protein also required for oocyte meiosis and differentiation. PMID: 22106259
10. GLD-1 is crucial for the CYE-1/CDK-2 mitosis/meiosis control PMID: 21455289
11. A comprehensive analysis of GLD-1 interaction with mRNA, providing a list of potential GLD-1 targets as well as a quantitative description of the determinants underlying mRNA recognition by GLD-1. PMID: 21169991
12. GLD-1 binds to TGE RNA and regulates tra-2 translation. PMID: 20573244
13. Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation PMID: 20223220
14. Low GLD-1 levels allow proliferation and increased levels promote meiotic entry. PMID: 14660440
15. identified the consensus STAR-binding element (SBE) required for specific mRNA recognition by GLD-1, a key regulator of germline development PMID: 14718919
16. Analysis of several mRNA targets containing premature stop codons suggests that in translation repression, GLD-1 either represses ribosome assembly on the target mRNA, or subsequent ribosome elongation to the premature stop codon. PMID: 15105376
17. GLD-1 mediates a developmental switch in the translational control of C. elegans PAL-1 PMID: 15201219
18. The RNA binding affinity of 11 mutant GLD-1 proteins was measured, and their binding specificity was assessed with a series of TGE RNAs containing natural or modified nucleotides PMID: 15663930
19. GLD-1 mediates its repressive effect by directly binding to the 3'UTR of cep-1/p53 mRNA and repressing its translation. PMID: 15707894

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KEGG: cel:CELE_T23G11.3

STRING: 6239.T23G11.3.2

UniGene: Cel.35026