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| Code | CSB-PA530347ZA01MO |
| Size | |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Full Product Name | Rabbit anti-Mus musculus (Mouse) Pde9a Polyclonal antibody |
| Uniprot No. | O70628 |
| Target Names | Pde9a |
| Alternative Names | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35), Pde9a, Pde8b |
| Raised in | Rabbit |
| Species Reactivity | Mus musculus |
| Immunogen | Recombinant Mus musculus Pde9a protein |
| Immunogen Species | Mus musculus (Mouse) |
| Conjugate | Non-conjugate |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | Protein A/G |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA, WB (ensure identification of antigen) |
| Protocols | ELISA Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Value-added Deliverables | ① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control); |
| Quality Guarantee | ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive; |
| Lead Time | Made-to-order (12-14 weeks) |
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| Function (From Uniprot) |
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory. |
| Gene References into Functions |
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| Subcellular Location | Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus. Endoplasmic reticulum. Cell membrane, sarcolemma. |
| Protein Families | Cyclic nucleotide phosphodiesterase family, PDE9 subfamily |
| Tissue Specificity | Highly expressed in kidney. Lower levels in liver, lung and brain. Widely expressed in brain, with highest expression in cerebellar Purkinje cells. Present in heart (at protein level). |
| Database Links |
KEGG: mmu:18585 STRING: 10090.ENSMUSP00000038005 UniGene: Mm.10812 |
