Pde9a Antibody

Code CSB-PA530347ZA01MO
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Product Details

Full Product Name Rabbit anti-Mus musculus (Mouse) Pde9a Polyclonal antibody
Uniprot No. O70628
Target Names Pde9a
Alternative Names High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC, Pde9a, Pde8b
Raised in Rabbit
Species Reactivity Mus musculus
Immunogen Recombinant Mus musculus Pde9a protein
Immunogen Species Mus musculus (Mouse)
Conjugate Non-conjugate
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (12-14 weeks)

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Target Background

(From Uniprot)
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory.
Gene References into Functions
  1. Brain PDE9 is localized to preferentially regulate nuclear- and membrane-proximal pools of cGMP, and its function likely changes across the life span. PMID: 29505961
  2. PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target. PMID: 25799991
  3. Data suggest that increases in hippocampal and amygdalar cGMP levels via blockade of PDE9 have prominent roles in consolidation of extinction learning (here, prevention of learning disorder due to cocaine neurotoxicity). PMID: 22596207
  4. This paper describes the human Pde9 gene but discusses the comparisons between the mouse and human Pde9 genes. PMID: 9624146
Subcellular Location Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus. Endoplasmic reticulum. Cell membrane, sarcolemma.
Protein Families Cyclic nucleotide phosphodiesterase family, PDE9 subfamily
Tissue Specificity Highly expressed in kidney. Lower levels in liver, lung and brain. Widely expressed in brain, with highest expression in cerebellar Purkinje cells. Present in heart (at protein level).
Database Links

KEGG: mmu:18585

STRING: 10090.ENSMUSP00000038005

UniGene: Mm.10812

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