Rasgrf1 Antibody

Code CSB-PA019360XA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Rasgrf1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Rasgrf1 antibody; Cdc25 antibody; Grf1 antibody; Ras-specific guanine nucleotide-releasing factor 1 antibody; Ras-GRF1 antibody; CDC25Mm antibody; Guanine nucleotide-releasing protein antibody; GNRP antibody; Ras-specific nucleotide exchange factor CDC25 antibody
Raised in
Rabbit
Species Reactivity
Mus musculus (Mouse)
Immunogen
Recombinant Mus musculus (Mouse) Rasgrf1 protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Promotes the exchange of Ras-bound GDP by GTP.
Gene References into Functions
  1. These findings demonstrate that RASgrf1 is closely associated with epilepsy via the aberrant methylation of RASgrf1, and regulating the methylation status of relevant genes might be an intriguing topic in future research on epilepsy. PMID: 28611277
  2. Novel mercaptoacetamide-based class II histone deacetylase inhibitor HDACIW2 treatment regulated the levels of RasGRF1 and p-ERK, and that W2 requires RasGRF1 and ERK signaling to alter dendritic spine formation, suggesting that W2 regulates dendritic spine formation via a RasGRF1/ERK-dependent signaling pathway PMID: 26890742
  3. Data (including data from studies in knockout mice) suggest mechanisms involving RasGRF1 exist to regulate hypothalamic-pituitary-adrenal axis in early-adolescent females; such mechanisms appear absent in younger/older female or adolescent male mice. PMID: 26246084
  4. VLDLR requires RasGRF1/CaMKII to alter dendritic spine formation. PMID: 25644714
  5. Study suggests a complex role of ERK-dependent and Ras-GRF1-dependent signaling in corticostriatal plasticity, highlights differences between synaptic mechanisms in naive slices and dopamine-depleted preparations from L-DOPA-treated dyskinetic animals PMID: 24844602
  6. RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses. PMID: 25421944
  7. CARD9 regulates H-Ras activation by linking Ras-GRF1 to H-Ras, which mediates Dectin-1-induced extracellular signal-regulated protein kinase (ERK) activation and proinflammatory responses when stimulated by their ligands. PMID: 25267792
  8. GRF1 is expressed in new neurons when GRF1 loss begins to effect neuronal function, promoting late stages of adult neurogenesis. GRF1 is an age-dependent regulator of adult hippocampal neurogenesis and the ability to distinguish closely related contexts. PMID: 24174283
  9. Data indicate that contextual discrimination involves term potentiation (LTP) promoted by calcium-permeable AMPA-type glutamate receptors, RAS-GRF1 and p38 MAP kinase. PMID: 23766509
  10. identified the guanine nucleotide exchange factor Rasgrf1 as a direct Zac1/Plagl1 target gene in beta cells PMID: 22547676
  11. Present RasGRF1-derived peptides displaying both in vitro and in vivo Ras inhibitory properties. PMID: 21620943
  12. p190A is required in both the epithelial and stromal compartments for ductal outgrowth and it may play a role in mammary epithelial cell differentiation PMID: 21945077
  13. these results indicate that Rasgrf1 expression from the wild-type paternal allele contributes to learning and memory in neonatal mice. PMID: 21251221
  14. Demonstrate a role for RasGRF1/2 as negative regulators of Cdc42 activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation. PMID: 21685891
  15. role of RASGRF1 in aging, lifespan and metabolic parameters were analyzed in aged RasGrf1(-/-) mice. We observed that mice deficient for RasGrf1(-/-) display an increase in average and most importantly, in maximal lifespan (20% higher than controls). PMID: 21422498
  16. study found components of the piRNA pathway are required for de novo methylation of the differentially methylated region of imprinted Rasgrf1 locus; propose a model in which piRNAs and a target RNA direct sequence-specific methylation of Rasgrf PMID: 21566194
  17. These data reveal the central role of Ras-GRF1 in governing striatal adaptations to dopamine replacement therapy and validate a viable treatment for LID based on intracellular signaling modulation. PMID: 21115823
  18. the evidence points towards the involvement of Rasgrf1 in the regulation of longevity, hypothetically through a mechanism similar to that observed in other long-lived mice of low GH/IGF-1 signaling causing a low body weight and life-extension PMID: 21182853
  19. Data show that noncoding RNA, AK029869, within the Rasgrf1 locus is imprinted. PMID: 21072176
  20. Imprinted Rasgrf1 expression levels are critical for development and affects IGF-1 function. PMID: 19513790
  21. First report of the role of RhoA-specific p190RhoGEF in immune cell activation following CD40 stimulation of WEHI 231 B cells. PMID: 12496377
  22. At Rasgrf1, a repeated DNA element is needed to establish methylation and expression of the active paternal allele. PMID: 12740578
  23. Results demonstrate a novel and specific role for Ras-GRF1 pathways in the development and maintenance of normal beta-cell number and function. PMID: 12805218
  24. RASGRF1 is an imprinted gene with a role in postnatal growth control PMID: 12925882
  25. phospholipase C-gamma2 regulates RasGRP3 localization and thereby Ras activation. PMID: 14676298
  26. Data show that Ras-GRF1 and Ras-GRF2 couple NMDA glutamate receptors to the activation of the Ras/Erk signaling cascade and to the maintenance of CREB transcription factor activity in cortical neurons of adult mice. PMID: 15029245
  27. RasGrf1 as a novel target of neurotrophin activation; an additional pathway whereby neurotrophin-stimulated neurite outgrowth may be regulated PMID: 15513915
  28. The differentially methylated domain (DMD)is an enhancer blocker that binds CTCF in a methylation-sensitive manner and thus regulates Rasgrf1. PMID: 16314537
  29. The isolated catalytic hairpin of Rasgrf1 retains dissociation activity but has impaired nucleotide exchange activity. PMID: 16325815
  30. Ras-GRF proteins have roles in coupling calcium-permeable AMPA glutamate receptors to Ras/Erk signaling in cortical neurons PMID: 16407208
  31. Mediates forms of synaptic plasticity by coupling different classes of NMDA receptors to distinct MAP kinase pathways. PMID: 16467520
  32. These data show that phosphorylation of RasGRF1 by Cdk5 tightly regulates its levels, which is essential for proper cellular organization. PMID: 16921254
  33. We conclude that p190 RhoGAPs control pivotal aspects of neural development, including neuronal differentiation and process outgrowth, and that these effects are mediated by signaling systems that include, but are not limited to, RhoA. PMID: 17028431
  34. Rasgrf1 repeats serve at least two functions: first, to establish Rasgrf1 DNA methylation in the male germ line, and second, to resist global demethylation in the preimplantation embryo. PMID: 17030618
  35. RasGRF1 lacks the allosteric activation switch that is crucial for Sos1 activity PMID: 17075039
  36. a physical and functional interaction between RasGRF1 and SCLIP; this novel interplay may have possible implications in mechanisms that regulate neuronal morphology and structural plasticity PMID: 17135267
  37. Delta-catenin T454A, a defective form in p190RhoGEF binding, did not decrease the binding between p190RhoGEF and RhoA. PMID: 17993462
  38. p190RhoGEF overexpression enhances RhoA activation and focal adhesion (FA) formation in Mouse embryonic fibroblasts dependent on FAK binding and is associated with p190RhoGEF FA recruitment and tyrosine phosphorylation. PMID: 18195107
  39. p190A is a novel GSK-3beta substrate; there is a mechanism by which GSK-3beta contributes to cellular polarization in directionally migrating cells via effects on Rho GTPase activity PMID: 18502760
  40. chronic tetrahydrocannabinol modulates the expression and subcellular localization of proteins implicated in Ras signaling, calcium-buffering potential, and trafficking PMID: 18584336
  41. The repressive H3K27 methylation and DNA methylation modifications are mutually antagonistic in the Rasgrf1 region. PMID: 18670629

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Brain.
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