Recombinant Mouse Ras-specific guanine nucleotide-releasing factor 1 (Rasgrf1), partial

1. These findings demonstrate that RASgrf1 is closely associated with epilepsy via the aberrant methylation of RASgrf1, and regulating the methylation status of relevant genes might be an intriguing topic in future research on epilepsy. PMID: 28611277
2. Novel mercaptoacetamide-based class II histone deacetylase inhibitor HDACIW2 treatment regulated the levels of RasGRF1 and p-ERK, and that W2 requires RasGRF1 and ERK signaling to alter dendritic spine formation, suggesting that W2 regulates dendritic spine formation via a RasGRF1/ERK-dependent signaling pathway PMID: 26890742
3. Data (including data from studies in knockout mice) suggest mechanisms involving RasGRF1 exist to regulate hypothalamic-pituitary-adrenal axis in early-adolescent females; such mechanisms appear absent in younger/older female or adolescent male mice. PMID: 26246084
4. VLDLR requires RasGRF1/CaMKII to alter dendritic spine formation. PMID: 25644714
5. Study suggests a complex role of ERK-dependent and Ras-GRF1-dependent signaling in corticostriatal plasticity, highlights differences between synaptic mechanisms in naive slices and dopamine-depleted preparations from L-DOPA-treated dyskinetic animals PMID: 24844602
6. RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses. PMID: 25421944
7. CARD9 regulates H-Ras activation by linking Ras-GRF1 to H-Ras, which mediates Dectin-1-induced extracellular signal-regulated protein kinase (ERK) activation and proinflammatory responses when stimulated by their ligands. PMID: 25267792
8. GRF1 is expressed in new neurons when GRF1 loss begins to effect neuronal function, promoting late stages of adult neurogenesis. GRF1 is an age-dependent regulator of adult hippocampal neurogenesis and the ability to distinguish closely related contexts. PMID: 24174283
9. Data indicate that contextual discrimination involves term potentiation (LTP) promoted by calcium-permeable AMPA-type glutamate receptors, RAS-GRF1 and p38 MAP kinase. PMID: 23766509
10. identified the guanine nucleotide exchange factor Rasgrf1 as a direct Zac1/Plagl1 target gene in beta cells PMID: 22547676
11. Present RasGRF1-derived peptides displaying both in vitro and in vivo Ras inhibitory properties. PMID: 21620943
12. p190A is required in both the epithelial and stromal compartments for ductal outgrowth and it may play a role in mammary epithelial cell differentiation PMID: 21945077
13. these results indicate that Rasgrf1 expression from the wild-type paternal allele contributes to learning and memory in neonatal mice. PMID: 21251221
14. Demonstrate a role for RasGRF1/2 as negative regulators of Cdc42 activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation. PMID: 21685891
15. role of RASGRF1 in aging, lifespan and metabolic parameters were analyzed in aged RasGrf1(-/-) mice. We observed that mice deficient for RasGrf1(-/-) display an increase in average and most importantly, in maximal lifespan (20% higher than controls). PMID: 21422498
16. study found components of the piRNA pathway are required for de novo methylation of the differentially methylated region of imprinted Rasgrf1 locus; propose a model in which piRNAs and a target RNA direct sequence-specific methylation of Rasgrf PMID: 21566194
17. These data reveal the central role of Ras-GRF1 in governing striatal adaptations to dopamine replacement therapy and validate a viable treatment for LID based on intracellular signaling modulation. PMID: 21115823
18. the evidence points towards the involvement of Rasgrf1 in the regulation of longevity, hypothetically through a mechanism similar to that observed in other long-lived mice of low GH/IGF-1 signaling causing a low body weight and life-extension PMID: 21182853
19. Data show that noncoding RNA, AK029869, within the Rasgrf1 locus is imprinted. PMID: 21072176
20. Imprinted Rasgrf1 expression levels are critical for development and affects IGF-1 function. PMID: 19513790
21. First report of the role of RhoA-specific p190RhoGEF in immune cell activation following CD40 stimulation of WEHI 231 B cells. PMID: 12496377
22. At Rasgrf1, a repeated DNA element is needed to establish methylation and expression of the active paternal allele. PMID: 12740578
23. Results demonstrate a novel and specific role for Ras-GRF1 pathways in the development and maintenance of normal beta-cell number and function. PMID: 12805218
24. RASGRF1 is an imprinted gene with a role in postnatal growth control PMID: 12925882
25. phospholipase C-gamma2 regulates RasGRP3 localization and thereby Ras activation. PMID: 14676298
26. Data show that Ras-GRF1 and Ras-GRF2 couple NMDA glutamate receptors to the activation of the Ras/Erk signaling cascade and to the maintenance of CREB transcription factor activity in cortical neurons of adult mice. PMID: 15029245
27. RasGrf1 as a novel target of neurotrophin activation; an additional pathway whereby neurotrophin-stimulated neurite outgrowth may be regulated PMID: 15513915
28. The differentially methylated domain (DMD)is an enhancer blocker that binds CTCF in a methylation-sensitive manner and thus regulates Rasgrf1. PMID: 16314537
29. The isolated catalytic hairpin of Rasgrf1 retains dissociation activity but has impaired nucleotide exchange activity. PMID: 16325815
30. Ras-GRF proteins have roles in coupling calcium-permeable AMPA glutamate receptors to Ras/Erk signaling in cortical neurons PMID: 16407208
31. Mediates forms of synaptic plasticity by coupling different classes of NMDA receptors to distinct MAP kinase pathways. PMID: 16467520
32. These data show that phosphorylation of RasGRF1 by Cdk5 tightly regulates its levels, which is essential for proper cellular organization. PMID: 16921254
33. We conclude that p190 RhoGAPs control pivotal aspects of neural development, including neuronal differentiation and process outgrowth, and that these effects are mediated by signaling systems that include, but are not limited to, RhoA. PMID: 17028431
34. Rasgrf1 repeats serve at least two functions: first, to establish Rasgrf1 DNA methylation in the male germ line, and second, to resist global demethylation in the preimplantation embryo. PMID: 17030618
35. RasGRF1 lacks the allosteric activation switch that is crucial for Sos1 activity PMID: 17075039
36. a physical and functional interaction between RasGRF1 and SCLIP; this novel interplay may have possible implications in mechanisms that regulate neuronal morphology and structural plasticity PMID: 17135267
37. Delta-catenin T454A, a defective form in p190RhoGEF binding, did not decrease the binding between p190RhoGEF and RhoA. PMID: 17993462
38. p190RhoGEF overexpression enhances RhoA activation and focal adhesion (FA) formation in Mouse embryonic fibroblasts dependent on FAK binding and is associated with p190RhoGEF FA recruitment and tyrosine phosphorylation. PMID: 18195107
39. p190A is a novel GSK-3beta substrate; there is a mechanism by which GSK-3beta contributes to cellular polarization in directionally migrating cells via effects on Rho GTPase activity PMID: 18502760
40. chronic tetrahydrocannabinol modulates the expression and subcellular localization of proteins implicated in Ras signaling, calcium-buffering potential, and trafficking PMID: 18584336
41. The repressive H3K27 methylation and DNA methylation modifications are mutually antagonistic in the Rasgrf1 region. PMID: 18670629

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KEGG: mmu:19417

STRING: 10090.ENSMUSP00000034912

UniGene: Mm.44561