Stat5b Antibody

Code CSB-PA022815XA01MO
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Product Details

Full Product Name Rabbit anti-Mus musculus (Mouse) Stat5b Polyclonal antibody
Uniprot No. P42232
Target Names Stat5b
Alternative Names Stat5b antibody; Signal transducer and activator of transcription 5B antibody
Raised in Rabbit
Species Reactivity Mus musculus (Mouse)
Immunogen Recombinant Mus musculus (Mouse) Stat5b protein
Immunogen Species Mus musculus (Mouse)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Gene References into Functions
  1. NK cell numbers are decreased in Stat5a-Stat5b tetramer-deficient double knockin mice, but the mechanism was not investigated. Here we show that STAT5 dimers are sufficient for NK cell development, whereas STAT5 tetramers mediate NK cell maturation and the expression of maturation-associated genes PMID: 29105654
  2. Study investigated whether RGS4 could participate in signalling pathways to regulate neurotropic events. These observations suggest that RGS4 is implicated in opioid dependent neuronal differentiation and neurite outgrowth via a "non-canonical" signaling pathway regulating STAT5B-directed responses. PMID: 28219718
  3. STAT5B is a crucial regulator of RICD in memory T cells in mice PMID: 29187589
  4. Our work is the first to report that an active form of Stat5b restored DCs tolerogenic functions that re-educated Tregs to re-establish and to sustain long-term protective immune response against diabetes in NOD mice. PMID: 27634616
  5. Data indicate that 89% of signal transducer and activator of transcription 5 (Stat5b)-CA mice in which the T2/Onc transposon had been mobilized died of progenitor B-cell acute lymphoblastic leukemia (B-ALL) by 3 months of age. PMID: 26500062
  6. STAT5B and MOF work as negative regulators in adipogenesis. PMID: 26388045
  7. liver STAT5b activation/masculinization occurred at puberty and suppression/feminization occurred during aging and in mutant mice with defects in growth hormone signaling. PMID: 26959975
  8. Loss of STAT5b had no effect on either sex. PMID: 24838184
  9. Increased expression of STAT5b + PDGFB led to increased expression of downstream STAT5b targets. PMID: 25302990
  10. non-obese-diabetic genetic background is critical to the Stat5b-mediated lymphomagenesis through regulation of Stat5 hyperactivation PMID: 23457589
  11. Stat5b confers protection against diabetes in the NOD mice by regulating the numbers and function of multiple immune cell types, especially by up-regulating CD4(+)CD25(+) regulatory T cells. PMID: 22789848
  12. STAT5 is a negative regulator of Follicular Helper (TFH) CD4+ T cell differentiation, primarily through regulation of the transcription factor Blimp-1. PMID: 22271576
  13. CPEB3 has a novel function in the nucleus as to suppress Stat5b-dependent EGFR gene transcription PMID: 20639532
  14. rigorously Treg-depleted Stat5b-CA TG versus WT CD4(+)CD25(-) Teffs caused less GVHD lethality associated with diminished Teff proinflammatory and increased Th2 anti-inflammatory cytokine responses PMID: 20442366
  15. Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). PMID: 12040024
  16. Stat5 regulated expression of peroxisome proliferator-activated receptor-gamma.These results highlight a novel role of Stat5 in adipocyte differentiation. PMID: 12089351
  17. Whereas Stat5b-/- knockout mice have decreased numbers of CD8+ memory cells, transgenic Stat5b expression markedly increases CD8+ memory T cell numbers, indicating its critical role in regulating homeostasis of this cell population. PMID: 12496402
  18. STAT 5 proteins are not activated by physiological levels of insulin in adipose tissue. PMID: 12604355
  19. A subset of STAT5B-deficient mice exhibit autoimmune pathology very similar to mice lacking IL-2 or its receptor components, characterized by lymphocytic infiltration of multiple organs, including the bone marrow. PMID: 14607901
  20. Stat5b pathway is a key molecular defect in NOD mice PMID: 14701862
  21. prolactin activation of Stat5b is important in suppressing 20alpha-HSD gene expression and thereby allowing the maintenance of progesterone levels that are required to sustain pregnancy PMID: 15471942
  22. STAT5b plays a critical role during steady-state hematopoietic stem cell engraftment and a chromosome 7 modifier locus regulates this activity. PMID: 15498858
  23. Results are consistent with the hypothesis that STAT5 proteins are involved in the feedback regulation of somatostatin neurones by GH, and that these neurones may respond to patterned GH secretion to reinforce sexual dimorphism in the GH axis. PMID: 15796771
  24. Our results suggest the potential involvement of STAT5b in Lck-mediated cellular transformation. PMID: 16446405
  25. Several female-predominant repressors are elevated in STAT5b-deficient males; these may contribute to the major loss of male gene expression seen in the absence of STAT5b. PMID: 16469768
  26. The cleaved cytosolic fragment of ICA512 enhances the transcription of secretory granule genes (including its own gene) by binding to tyrosine phosphorylated signal transducers and activators of transcription (STAT) 5 and preventing its dephosphorylation. PMID: 16622421
  27. STAT5B protein function in preimplantation development by mediating the signals from cytokines PMID: 16775227
  28. we generated transgenic mice that expressed a constitutive active mutant of STAT5b (CASTAT5) under control of rat insulin 1 promoter. When subjected to high-fat diet, RIP-CASTAT5 mice were more glucose tolerant & less hyperleptinemic than wild-type mice. PMID: 17003334
  29. Therapeutic activation of the GH:STAT5b axis therefore represents a novel target for restoring both normal anabolic metabolism and mucosal tolerance in CD. PMID: 17148664
  30. the major loss of liver sexual dimorphism in hepatocyte STAT5ab-deficient mice can primarily be attributed to the loss of STAT5b PMID: 17317776
  31. JAK-Stat5B defective pathway in NOD mice along with other defective factors is associated with the pathogenesis of autoimmune type 1 diabetes in NOD mice. PMID: 17382905
  32. The transcription factor Stat5b is not required for islet development but modulates beta-cell physiology upon aging. PMID: 17599554
  33. Stat5b directly control IL-7-mediated early B cell development but are not required for B cell maturation and Ig production PMID: 17617599
  34. alterations in T-cell development at the double-negative/double-positive (DN/DP) stages cooperate with cytokine-mediated pathways in immature thymocytes to give rise to lymphoblastic T-cell lymphomas in Stat5b TG mice PMID: 17890450
  35. murine OSMR initiates STAT5 activation directly via the receptor bound Janus kinases. Intriguingly, the murine receptor preferentially recruits JAK2, whereas the human receptor seems to have a higher affinity for JAK1. PMID: 18430728
  36. The enhanced SULT1E1 activity may have a role in inhibiting GH-stimulated STAT5b phosphorylation and IGF-1 synthesis via the sulfation and inactivation of E2. PMID: 18831980
  37. STAT5b signaling is critical for leukemia stem cell self-renewal in MN1- and HOXA9-expressing leukemias. PMID: 19667399

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Subcellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Protein Families Transcription factor STAT family
Tissue Specificity In the virgin, found in most tissues. Particularly abundant in muscle tissue of virgin and lactating females, and of males.
Database Links

KEGG: mmu:20851

STRING: 10090.ENSMUSP00000004143

UniGene: Mm.34064

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