Function
(From Uniprot) |
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge. Required for normal embryonic development, and especially for limb development.
|
| Gene References into Functions |
- Demonstrate a significant change in miRNA profile dependent on the assisted reproductive technology outcome affecting Wnt pathway. PMID: 28971890
- High expression of WNT3 is associated with hepatocellular carcinoma. PMID: 28586038
- Our data demonstrated an important interdependence between TGF-beta and Wnt/beta-catenin pathways inducing EMT in HER2-overexpressing breast cancer cells. Twist served as a linkage between the two pathways during TGF-beta-induced EMT. A83-01 could inhibit the TGF-beta-initiated pathway interactions and enhance HER2-cells response to trastuzumab treatment PMID: 28337662
- YAP maintains human embryonic stem cells pluripotency by preventing WNT3 expression in response to Activin, thereby blocking a direct route to embryonic cardiac mesoderm formation. PMID: 29269485
- Wnt3 is associated with cholesterol-dependent domains PMID: 27463143
- analysis of WNT3 expression in CLL patients demonstrated that (i) untreated patients with more aggressive disease (with a notable exception of patients with 11q deletion) express less WNT3, (ii) WNT3 declines with disease progression in a significant proportion of patients and (iii) low WNT3 was identified as a strong independent marker indicating shorter treatment-free survival in CLL patients with IGHV mutation. PMID: 27651098
- PRKX, WNT3 and WNT16 genes, belonging to the WNT signaling pathway, are involved in the tumorigenic process of nodular basal cell carcinoma PMID: 27630294
- Two SNPs (rs3809857 and rs9890413) in the WNT3 gene were subjected to case-control and case-parent analysis PMID: 26505415
- WNT3 and membrane-associated beta-catenin regulate trophectoderm lineage differentiation in human blastocysts. PMID: 26108805
- WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish PMID: 26105184
- Genome association study shows a highly conserved 32 kb intergenic region containing regulatory elements between WNT3 and WNT9B in patients with classic bladder exstrophy. PMID: 24852367
- mRNA level of WNT3 in hESCs correlates with their definitive ectoderm differentiation efficiency. PMID: 24052941
- Data show that the WNT/beta-CATENIN signaling cascade components, including WNT ligands WNT3 and WNT5A, is crucial for early odontogenesis. PMID: 24647585
- WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation. PMID: 24303070
- Colorectal tumors express elevated levels of Wnt3 and GPR177. PMID: 24162018
- WNT3 and WNT5B are critical factors, secreted from mesenchymal cancer cells, for instigating the epithelial cancer cell invasion. PMID: 24344732
- Knockdown of Wnt3 by siRNA restored cytoplasmic expression of beta-catenin. PMID: 23071104
- The apoptotic index was significantly lower in high-Wnt3 tumors than in low-Wnt3 tumors (P=0.0245). PMID: 22070884
- study confirmed the involvement of polymorphisms in the WNT3 gene in NCL/P aetiology in the tested population. PMID: 22288914
- The findings of a significant association between lip and/or palate clefts and two markers in the WNT3 and COL11A2 genes were the most consistent and were observed in all groups analysed and stratified. PMID: 22112025
- SNP rs415430 in the WNT3 gene was not associated with the risk of development of Parkinson disease PMID: 21789800
- Extracellular domain of FZD7 (sFZD7) was tested for its functional activity to interact with Wnt3, its ability to inhibit Wnt3-mediated signaling. PMID: 21314951
- Abnormalities of the Wnt3/3a pathway (located in the apical ectodermal ridge) include tetra-amelia and loss of the distal phalanges/nails. PMID: 20709709
- Individuals carrying variant alleles in WNT3 presented an increased risk for cleft lip/palate (p = 0.0003; OR, 1.61; 95% CI, 1.29-2.02) in the Brazilian population studied. PMID: 20890934
- Results demonstrated significant up-regulation of WNT-3, WNT-4, WNT-5B, WNT-7B, WNT-9A, WNT-10A, and WNT-16B in patients with CLL compared to normal subjects. PMID: 19863181
- Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45 PMID: 11788904
- Wnt3 plays an important role in regulating characteristics and activity of stromal cells. PMID: 15588944
- The Wnt-3a triggers the interaction of LRP6 with caveolin and promotes recruitment of Axin to LRP6 phosphorylated by glycogen synthase kinase-3beta and that caveolin thereby inhibits the binding of beta-catenin to Axin. PMID: 16890161
- an internally truncated LRP5 receptor is strongly implicated in deregulated activation of the WNT/beta-catenin signaling pathway in hyperparathyroid tumors PMID: 18044981
- The results indicated that HBx induction in the CCL13-HBx stable cell line downregulated Wnt-3/beta-catenin expression and suppressed cell growth by repressing cell proliferation or triggering cell apoptosis. PMID: 18309246
- a functional interaction between Wnt3 and FZD7 leading to activation of the Wnt/beta-catenin signaling pathway in HCC cells and may play a role during hepatocarcinogenesis. PMID: 18313787
- CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors PMID: 18563180
- WNT3 regulates distinct internalization pathways of LRP6 to tune the activation of beta catenin signaling. PMID: 18606139
- mantle cell lymphoma highly and consistently expressed Wnt3 and Wnt10. PMID: 18787224
- WNT activity regulates the self-renewal of prostate cancer cells with stem cell characteristics independently of androgen receptor activity. PMID: 19365403
Show More
Hide All
|
