Human Transforming growth factor-beta-induced protein ig-h3 (TGFBI/BIGH3) ELISA kit

Code CSB-E16665h
Size 96T,5×96T,10×96T
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Product Details

Target Name
transforming growth factor, beta-induced, 68kDa
Alternative Names
RGD containing collagen associated protein ELISA Kit; AI181842 ELISA Kit; AI747162 ELISA Kit; Beta ig ELISA Kit; Beta ig h3 ELISA Kit; Beta ig-h3 ELISA Kit; BGH3_HUMAN ELISA Kit; Big h3 ELISA Kit; BIGH3 ELISA Kit; CDB1 ELISA Kit; CDG2 ELISA Kit; CDGG1 ELISA Kit; CSD ELISA Kit; CSD1 ELISA Kit; CSD2 ELISA Kit; CSD3 ELISA Kit; EBMD ELISA Kit; Kerato epithelin ELISA Kit; Kerato-epithelin ELISA Kit; LCD1 ELISA Kit; MGC150270 ELISA Kit; RGD CAP ELISA Kit; RGD-CAP ELISA Kit; RGD-containing collagen-associated protein ELISA Kit; TGFBI ELISA Kit; TGFBI transforming growth factor, beta induced, 68kDa ELISA Kit; Transforming growth factor beta induced protein ig h3 ELISA Kit; Transforming growth factor-beta-induced protein ig-h3 ELISA Kit
Uniprot No.
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
78 pg/mL-5000 pg/mL
19.5 pg/mL
Assay Time
Sample Volume
Detection Wavelength
450 nm
Research Area
Assay Principle
and FAQs
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

This Human TGFBI ELISA Kit was designed for the quantitative measurement of Human TGFBI protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 78 pg/mL-5000 pg/mL and the sensitivity is 19.5 pg/mL.

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Target Background

(From Uniprot)
Plays a role in cell adhesion. May play a role in cell-collagen interactions.
Gene References into Functions
  1. These results suggest that suppression of osteoblast differentiation by BIGH3 is one of the mechanisms that enhance osteolytic lesions in RCC bone metastasis, and raise the possibilty that treatments that increase bone formation may improve therapy outcomes. PMID: 29190493
  2. High TGFBI expression was significantly associated with poor prognosis and cancer progression. Downregulation of TGFBI in the cocultured gastric fibroblasts inhibited the invasion and migration abilities of the GC cells. PMID: 30260476
  3. Expression array analysis identified TGFBI as a key gene for the acquisition of malignant phenotype of pancreatic ductal adenocarcinoma (PDAC), and the expression of TGFBI was associated with poor prognosis in patients with PDAC. PMID: 30156359
  4. the genetic screening of TGFBI mutations must be incorporated into the pre-operative screening procedures to prevent exacerbation and recurrence, which eventually could lead to the need for a corneal transplant. PMID: 29192679
  5. Structural and functional implications of TGFBIp mutations in corneal dystrophies have been reported. PMID: 28988748
  6. Induction of TGFBI promotes prostate cancer growth and metastasis and can be caused by dysregulation or therapeutic inhibition of androgen receptor signaling. PMID: 28811384
  7. betaig-h3 in DPCs may be involved in reparative dentin formation and that its expression is likely to negatively regulate this process. PMID: 28292713
  8. This is the first molecular analysis of TGFBI and CHST6 in Turkish patients with different types of corneal dystrophies. PMID: 27829782
  9. The more structurally organized A546T and V624M mutations in FAS1-4 domain of TGFBI had reduced deamidation rates, suggesting that a folded and stable FAS1-4 domain precludes Asn622 deamidation. PMID: 29140698
  10. A novel heterozygous TGFBI mutation was identified in the proband, c.1673T>G in exon 12 that leads to (Leu558Arg) change at the protein level. PMID: 27028151
  11. TGFBI and periostin act similarly in the heart in affecting fibrosis and disease responsiveness. PMID: 28750100
  12. The p.(Val113Ile) mutation results in an alteration of the atypical LCD phenotype associated with the p.(Leu558Pro) mutation. This represents only the second report of the alteration of the phenotype of a TGFBI dystrophy by a second, non-homozygous pathogenic mutation, and thus provides insight into the phenotype-genotype correlation of the TGFBI dystrophies. PMID: 27402970
  13. Our findings demonstrate that granular corneal dystrophy type 1 may present with a vortex pattern of anterior stromal deposits. Although this pattern of dystrophic deposits is not recognized by clinicians as a typical phenotype of GCD1, it is consistent with the production of the majority of the TGFBI protein by the corneal epithelium. PMID: 28060069
  14. The right cornea showed a higher number of lattice lines than the left cornea. Molecular analysis involving bidirectional complete sequencing demonstrated a novel T621P mutation in exon 14 of TGFBI. PMID: 27163623
  15. LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing TGFBI protein. PMID: 26864644
  16. High TGFBI expression in Esophageal squamous cell carcinoma is associated with hematogenous recurrence. PMID: 25448803
  17. Vicenin-2 and scolymoside could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. PMID: 26084452
  18. We observed that knockdown of Cul4A was associated with increased sensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells. PMID: 26503734
  19. Data suggest that periostin and TGFBI (transforming growth factor-beta induced protein) can be considered paralogs in some ways: structural homology, phylogeny, and functions in extracellular matrix formation/cell adhesion/cellular immunity. [REVIEW] PMID: 26288337
  20. No mutations were detected in the TGFBI gene in Korean patients with macular corneal dystrophy. PMID: 26604660
  21. TGFBIp functions as a pro-lymphangiogenic factor.TGFBI is a lymphangiogenic factor contributing to tumor dissemination PMID: 25772247
  22. Studies reveal that growth hormone (GH)increases TGFBI expression in a mouse and rat models of diabetic nephropathy (DN) which correlate with clinical results, and suggest that this mechanism can explain the podocytes depletion in DN. PMID: 25740786
  23. the functional role of H3K4me in TGFbeta1-mediated TGFBIp and ECM gene expression in corneal fibroblasts PMID: 26553048
  24. 19 novel TGFB1 regulatory region and exon 1 alleles are presented: p018-p036. p018, p019, and p020 are formed by novel combinations of known polymorphic positions. Another 16 novel alleles are shown to carry additional known and unknown SNPs. PMID: 25808355
  25. The p. Arg555Trp mutation of the TGFBI gene was associated with Thiel-Behnke corneal dystrophy, which revealed a novel phenotype-genotype correlation within the mutational spectrum of phenotypically diverse corneal dystrophies. PMID: 26464103
  26. that locally generated TGFBIp at either wounds or tumor sites may contribute to differentiation and angiogenic function of endothelial progenitor cells by augmenting the recruitment of endothelial progenitor cells PMID: 25786978
  27. TGFBI functions as a promoter of certain gastrointestinal tract cancers. PMID: 25889002
  28. The authors present a unilateral variant of late-onset LCD with a heterozygous Pro501Thr mutation in the TGFBI gene. PMID: 23884333
  29. insights on TGFBIp trafficking PMID: 25853243
  30. TGFBI plays an important role in the progression of colorectal cancers PMID: 25755764
  31. Betaig-h3 protein expressed distinctly in gastric cancer peritoneal metastasis. PMID: 25864756
  32. The results support a novel inflammatory pathway for diabetic retinopathy. This pathway is initiated by TGFbeta released from macrophages, which promotes synthesis and release of BIGH3 protein by REC and REC apoptosis. PMID: 25378215
  33. Silencing of DDR1 inhibited tumor cell growth and motility, and induced TGFBI expression, both in vitro and in vivo. PMID: 25369402
  34. A de novo R124C mutation of the TGFBI gene may occur in one of dizygotic twins. Patients with an R124C mutation may have clinical features like corneal dystrophy of the Bowman layer. PMID: 25785536
  35. The patient in this reprot showed typical asymmetric ndulinear stromal opacity in both corneas, and an L527R mutation in the TGFBI gene with two SNP mutations. PMID: 24505203
  36. We present the characteristics and surgical treatment of corneas with a novel A620P mutation in TGFBI showing lattice corneal dystrophy type IIIA with hyaline component. PMID: 25321938
  37. Granular corneal dystrophy type II can co-exist with keratoconus and should be included in the differential diagnosis. PMID: 24582869
  38. TGFBI is a potential risk gene for human diabetes. PMID: 24728038
  39. a small difference in thermodynamic stability introduced by the P551Q mutation most likely causes structural changes of TGFBIp. PMID: 24302499
  40. The TGFBI gene, that is responsible for lattice corneal dystrophy type 1, is expressed above all by the corneal epithelial cells but also by the keratocytes PMID: 25055147
  41. Integrins alphavbeta5 and alphavbeta3 both control myofibroblast differentiation by activating latent TGF-beta1 PMID: 24639195
  42. These results reveal betaig-h3 enhances the metastasis potentials of human osteosarcoma cells via integrin alpha2beta1-mediated PI3K/AKT signal pathways. PMID: 24595049
  43. This study improves the knowledge of the genetic features of Mexican patients with corneal stromal dystrophies by identifying mutations in the TGFBI, CHST6, and GSN genes. PMID: 24801599
  44. Pin1 induction during liver fibrosis is involved in hepatic stellate cell activation, TGFbeta1 expression, and TGFbeta1-mediated fibrogenesis signalling. PMID: 24530597
  45. The H19-miR-675 axis acts as a suppressor of prostate cancer metastasis via modulation of TGFBI expression. PMID: 24988946
  46. Induced BIGH3 expression upon BM stress may contribute to the regulation of BM homeostasis PMID: 24152593
  47. A novel heterozygous missense mutation p.Leu565Pro was identified in exon 13 of the TGFBI gene. PMID: 24473223
  48. TGFBI dysregulation could occur in HBV-related HCC development. PMID: 24662304
  49. TGFBI is required for melanoma metastatic outgrowth; knockdown does not interfere with melanoma cells' dissemination to the lung PMID: 24499734
  50. Circulating levels of TGFBIp were significantly elevated in septic patients compared with healthy controls, and were strongly correlated with disease severity. TGFBIp enhanced vascular proinflammatory responses through interacting with integrin alphavbeta5. PMID: 24506343

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Involvement in disease
Corneal dystrophy, epithelial basement membrane (EBMD); Corneal dystrophy, Groenouw type 1 (CDGG1); Corneal dystrophy, lattice type 1 (CDL1); Corneal dystrophy, Thiel-Behnke type (CDTB); Corneal dystrophy, Reis-Bucklers type (CDRB); Corneal dystrophy, lattice type 3A (CDL3A); Corneal dystrophy, Avellino type (CDA)
Subcellular Location
Secreted. Secreted, extracellular space, extracellular matrix.
Tissue Specificity
Highly expressed in the corneal epithelium. Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Database Links

HGNC: 11771

OMIM: 121820

KEGG: hsa:7045

STRING: 9606.ENSP00000416330

UniGene: Hs.369397

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