Rat Kidney injury molecule 1,Kim-1 ELISA Kit

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Code	CSB-E08808r
Size	96T,5×96T,10×96T
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Target Data

Product Details

Target Name	hepatitis A virus cellular receptor 1
Alternative Names	Havcr1 ELISA Kit; Kim1 ELISA Kit; Hepatitis A virus cellular receptor 1 homolog ELISA Kit; HAVcr-1 ELISA Kit; Kidney injury molecule 1 ELISA Kit; KIM-1 ELISA Kit; T cell immunoglobulin and mucin domain-containing protein 1 ELISA Kit; TIMD-1 ELISA Kit; CD antigen CD365 ELISA Kit
Abbreviation	Kim-1
Uniprot No.	O54947
Species	Rattus norvegicus (Rat)
Sample Types	serum, plasma, urine
Detection Range	0.313 ng/mL-20 ng/mL
Sensitivity	0.228 ng/mL
Assay Time	1-5h
Sample Volume	50-100ul
Detection Wavelength	450 nm
Research Area	Immunology
Assay Principle	quantitative
Measurement	Sandwich
Precision	Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess.
Linearity	To assess the linearity of the assay, samples were spiked with high concentrations of Rat Kim-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
Typical Data	These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
Troubleshooting and FAQs	ELISA kit FAQs
Storage	Store at 2-8°C. Please refer to protocol.
Lead Time	3-5 working days

Citations

HO-1/PINK1 Regulated Mitochondrial Fusion/Fission to Inhibit Pyroptosis and Attenuate Septic Acute Kidney Injury HB Li,BioMed Research International,2020
Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis Z He,International Journal,2020
Circular RNA VMA21 ameliorates sepsis‐associated acute kidney injury by regulating miR‐9‐3p/SMG1/inflammation axis and oxidative stress Y Shi,J. Cell. Mol. Med.,2020
MiR-122-5p and miR ‐326‐3p promote cadmium‐induced NRK‐52E cell apoptosis by downregulating PLD1 W Yuan,Environ. Toxicol,2020
Ameliorative Effect of Propolis Against Thioacetamide Induced Hepatorenal Injury in Adult Male Rats. Kidney Injury Molecule-1 (KIM-1) a Biomarker of Renal Injury FE SAMAR,The Medical Journal of cairo university,2020
The effects of synthetic orally administrated insulin nanoparticles in comparison to injectable insulin on the renal function markers of type 1-diabetic rats N Keiripour,Iranian Journal of Bascic Medical Sciences,2020
The possible protective effects of saccharum officinarum l. (sugar cane) juice co-supplementation on gentamicin induced acute renal toxicity in adult albino rats Asmaa Y. A,International Journal of Pharmacology and Toxicology,2020
Impact of betanin against paracetamol and diclofenac induced hepato-renal damage in rats Motawi T K, et al,Biomarkers,2019
Autophagy-endoplasmic reticulum stress inhibition mechanism of superoxide dismutase in the formation of calcium oxalate kidney stones Juening Kang, et al,Biomedicine & Pharmacotherapy,2019
Pioglitazone attenuates kidney injury in an experimental model of gentamicin-induced nephrotoxicity in rats Medic B, et al,Scientific Reports,2019
Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats Aladaileh S H, et al,Antioxidants,2019
Reno-protective effect of linagliptin against gentamycin nephrotoxicity in rats Mai M. Helmy, et al,Oxidative Medicine and Cellular Longevity,2019
Camel milk attenuates methotrexate-induced kidney injury: Via activation of PI3K/Akt/eNOS signaling and intervention with oxidative aberrations Arab HH,FOOD & FUNCTION,2019
Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis Ayman M. Mahmoud,Food & Function,2019
Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling Abd El-Twab SM,Inflammation Research,2019
Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes Hassan Ghasemi, et al,Iranian Journal of Basic Medical Sciences,2019
Wnt4 is significantly upregulated during the early phases of cisplatin-induced acute kidney injury Yi-Xin He.et al,Scientific Reports,2018
miR-182 enhances acute kidney injury by promoting apoptosis involving the targeting and regulation of TCF7L2/Wnt/B-catenins pathway HuicongLi.et al,European Journal of Pharmacology,2018
Inhibition of Autophagy Attenuated Ethylene Glycol Induced Crystals Deposition and Renal Injury in a Rat Model of Nephrolithiasis Liu Y.et al,Kidney Blood Press Res,2018
Camel milk attenuates methotrexate-induced kidney injury via activation of PI3K/Akt/eNOS signaling and intervention with oxidative aberrations Hany H. Arab.et al,Food Funct,2018
Preservation of kidney function with combined inhibition of NADPH oxidase and angiotensin-converting enzyme in diabetic nephropathy Thallas-Bonke V. et al,American Journal of Nephrology,2010

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Target Data

Function	May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair (By similarity).
Gene References into Functions	High KIM1 expression is associated with decreased proximal tubular epithelial cell function. PMID: 29045706 urinary KIM1 may be a valuable biomarker for the early diagnosis of obstructive AKI, and the use of a colloidal gold immunochromatographic strip may be a promising method for the rapid detection of urinary KIM1. PMID: 28075469 Results show that in contrast to other known molecules indicating renal injury and/or repair mechanisms, the chronic renal expression of Kim-1 is strictly confined to proximal cysts. PMID: 27231899 blood biomarker that specifically reflects acute and chronic kidney injury PMID: 24904085 Ischemic postconditioning can attenuate the renal ischemia reperfusion injury and downregulate the expression of Kim-1. PMID: 22898836 These studies are the first direct demonstration of regulation of KIM-1 in response to oxalate exposure in renal epithelial cells in vitro and in vivo. PMID: 22984472 The most sensitive, noninvasive biomarkers of HCBD-induced renal toxicity in Hanover Wistar rats were urinary alpha-GST and KIM-1. PMID: 21905055 The Kim1 gene is regulated in an epigenetic fashion under conditions of nephrotoxicity. PMID: 20660082 Results show Kim-1 outperforms SCr, BUN and urinary NAG in multiple rat models of kidney injury. PMID: 20458318 KIM-1 as a sensitive molecular marker of different levels of tubular injury PMID: 20305092 Urinary Kim-1 serve as a noninvasive, rapid, sensitive, reproducible method to detect early kidney injury in pathophysiological studies and in preclinical drug development studies for risk-benefit profiling of pharmaceutical agents. PMID: 16174863 These results implicate involvement of kidney injury molecule 1 (Kim-1) in the pathogenesis of proteinuria-induced renal damage/repair. Urinary Kim-1 levels may serve as a marker of proteinuria-induced renal damage. PMID: 16467126 Kim-1 is associated with development of renin-angiotensin system-mediated renal damage PMID: 16896183 Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury PMID: 17934191 Data demonstrate that injured kidney epithelial cells assumed attributes of endogenous phagocytes, and that KIM-1 was directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and also porcine and canine epithelial cell lines. PMID: 18414680 on longitudinal follow-up during antiproteinuric treatment increased renal Kim-1 expression is reversible in proportion to proteinuria reduction, likely reflecting reversibility of early tubular injury PMID: 19225054 Cadmium-induced increase in Kim-1 expression occurs before the onset of necrosis and at a point where there is only a modest level of apoptosis in the proximal tubule. PMID: 19371613 Kim-1 is a sensitive biomarker of the early stages of Cadmium-induced proximal tubule injury. PMID: 19371616 Dipsticks can provide a sensitive and accurate detection of Havcr1. PMID: 19387469 Kim-1 is a promising novel marker for the early, organ specific and noninvasive detection of brain death-induced donor kidney damage. PMID: 19522876 Show More Hide All
Subcellular Location	Membrane, Single-pass type I membrane protein
Protein Families	Immunoglobulin superfamily, TIM family
Tissue Specificity	Expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. Expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules.
Database Links	KEGG: rno:286934 STRING: 10116.ENSRNOP00000009573 UniGene: Rn.11154

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