Rat Kidney injury molecule 1,Kim-1 ELISA Kit

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Code	CSB-E08808r
Size	96T,5×96T,10×96T
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Product Details
Citations
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Target Data

Product Details

Target Name	hepatitis A virus cellular receptor 1
Alternative Names	Havcr1 ELISA Kit; Kim1 ELISA Kit; Hepatitis A virus cellular receptor 1 homolog ELISA Kit; HAVcr-1 ELISA Kit; Kidney injury molecule 1 ELISA Kit; KIM-1 ELISA Kit; T cell immunoglobulin and mucin domain-containing protein 1 ELISA Kit; TIMD-1 ELISA Kit; CD antigen CD365 ELISA Kit
Abbreviation	Kim-1
Uniprot No.	O54947
Species	Rattus norvegicus (Rat)
Sample Types	serum, plasma, urine
Detection Range	0.313 ng/mL-20 ng/mL
Sensitivity	0.228 ng/mL
Assay Time	1-5h
Sample Volume	50-100ul
Detection Wavelength	450 nm
Research Area	Immunology
Assay Principle	quantitative
Measurement	Sandwich
Precision	Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess.
Linearity	To assess the linearity of the assay, samples were spiked with high concentrations of Rat Kim-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
Typical Data	These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
Troubleshooting and FAQs	ELISA kit FAQs
Storage	Store at 2-8°C. Please refer to protocol.
Lead Time	3-5 working days

Citations

The possible protective effects of saccharum officinarum l. (sugar cane) juice co-supplementation on gentamicin induced acute renal toxicity in adult albino rats Asmaa Y. A,International Journal of Pharmacology and Toxicology,2020
Impact of betanin against paracetamol and diclofenac induced hepato-renal damage in rats Motawi T K, et al,Biomarkers,2019
Autophagy-endoplasmic reticulum stress inhibition mechanism of superoxide dismutase in the formation of calcium oxalate kidney stones Juening Kang, et al,Biomedicine & Pharmacotherapy,2019
Pioglitazone attenuates kidney injury in an experimental model of gentamicin-induced nephrotoxicity in rats Medic B, et al,Scientific Reports,2019
Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats Aladaileh S H, et al,Antioxidants,2019
Reno-protective effect of linagliptin against gentamycin nephrotoxicity in rats Mai M. Helmy, et al,Oxidative Medicine and Cellular Longevity,2019
Camel milk attenuates methotrexate-induced kidney injury: Via activation of PI3K/Akt/eNOS signaling and intervention with oxidative aberrations Arab HH,FOOD & FUNCTION,2019
Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis Ayman M. Mahmoud,Food & Function,2019
Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling Abd El-Twab SM,Inflammation Research,2019
Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes Hassan Ghasemi, et al,Iranian Journal of Basic Medical Sciences,2019
Wnt4 is significantly upregulated during the early phases of cisplatin-induced acute kidney injury Yi-Xin He.et al,Scientific Reports,2018
miR-182 enhances acute kidney injury by promoting apoptosis involving the targeting and regulation of TCF7L2/Wnt/B-catenins pathway HuicongLi.et al,European Journal of Pharmacology,2018
Inhibition of Autophagy Attenuated Ethylene Glycol Induced Crystals Deposition and Renal Injury in a Rat Model of Nephrolithiasis Liu Y.et al,Kidney Blood Press Res,2018
Camel milk attenuates methotrexate-induced kidney injury via activation of PI3K/Akt/eNOS signaling and intervention with oxidative aberrations Hany H. Arab.et al,Food Funct,2018
Preservation of kidney function with combined inhibition of NADPH oxidase and angiotensin-converting enzyme in diabetic nephropathy Thallas-Bonke V. et al,American Journal of Nephrology,2010

Target Data

Function	May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair (By similarity).
Gene References into Functions	High KIM1 expression is associated with decreased proximal tubular epithelial cell function. PMID: 29045706 urinary KIM1 may be a valuable biomarker for the early diagnosis of obstructive AKI, and the use of a colloidal gold immunochromatographic strip may be a promising method for the rapid detection of urinary KIM1. PMID: 28075469 Results show that in contrast to other known molecules indicating renal injury and/or repair mechanisms, the chronic renal expression of Kim-1 is strictly confined to proximal cysts. PMID: 27231899 blood biomarker that specifically reflects acute and chronic kidney injury PMID: 24904085 Ischemic postconditioning can attenuate the renal ischemia reperfusion injury and downregulate the expression of Kim-1. PMID: 22898836 These studies are the first direct demonstration of regulation of KIM-1 in response to oxalate exposure in renal epithelial cells in vitro and in vivo. PMID: 22984472 The most sensitive, noninvasive biomarkers of HCBD-induced renal toxicity in Hanover Wistar rats were urinary alpha-GST and KIM-1. PMID: 21905055 The Kim1 gene is regulated in an epigenetic fashion under conditions of nephrotoxicity. PMID: 20660082 Results show Kim-1 outperforms SCr, BUN and urinary NAG in multiple rat models of kidney injury. PMID: 20458318 KIM-1 as a sensitive molecular marker of different levels of tubular injury PMID: 20305092 Urinary Kim-1 serve as a noninvasive, rapid, sensitive, reproducible method to detect early kidney injury in pathophysiological studies and in preclinical drug development studies for risk-benefit profiling of pharmaceutical agents. PMID: 16174863 These results implicate involvement of kidney injury molecule 1 (Kim-1) in the pathogenesis of proteinuria-induced renal damage/repair. Urinary Kim-1 levels may serve as a marker of proteinuria-induced renal damage. PMID: 16467126 Kim-1 is associated with development of renin-angiotensin system-mediated renal damage PMID: 16896183 Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury PMID: 17934191 Data demonstrate that injured kidney epithelial cells assumed attributes of endogenous phagocytes, and that KIM-1 was directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and also porcine and canine epithelial cell lines. PMID: 18414680 on longitudinal follow-up during antiproteinuric treatment increased renal Kim-1 expression is reversible in proportion to proteinuria reduction, likely reflecting reversibility of early tubular injury PMID: 19225054 Cadmium-induced increase in Kim-1 expression occurs before the onset of necrosis and at a point where there is only a modest level of apoptosis in the proximal tubule. PMID: 19371613 Kim-1 is a sensitive biomarker of the early stages of Cadmium-induced proximal tubule injury. PMID: 19371616 Dipsticks can provide a sensitive and accurate detection of Havcr1. PMID: 19387469 Kim-1 is a promising novel marker for the early, organ specific and noninvasive detection of brain death-induced donor kidney damage. PMID: 19522876 Show More Hide All
Subcellular Location	Membrane, Single-pass type I membrane protein
Protein Families	Immunoglobulin superfamily, TIM family
Tissue Specificity	Expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. Expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules.
Database Links	KEGG: rno:286934 STRING: 10116.ENSRNOP00000009573 UniGene: Rn.11154

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