Recombinant Human Galectin-1 protein(LGALS1) (Active)

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Code CSB-AP000471HU
Product Type Other
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Uniprot No. P09382
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Storage Buffer 0.2 μm filtered PBS, pH 7.4, with 1 mM DTT ,lyophilized
Alias Gal-1, HLBP14, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human blood monocytes is in a concentration range of 1.0-10 ng/ml.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence ACGLVASNLN LKPGECLRVR GEVAPDAKSF VLNLGKDSNN LCLHFNPRFN AHGDANTIVC NSKDGGAWGT EQREAVFPFQ PGSVAEVCIT FDQANLTVKL PDGYEFKFPN RLNLEAINYM AADGDFKIKC VAFD
Research Area Cancer
Source E.Coli
Gene Names LGALS1
Expression Region 2-135aa
Tag Info Tag-Free
Mol. Weight 14.6 kDa
Protein Description Full Length of Mature Protein
PubMed ID 2719964; 2910856; 2719646; 18824694; 1988031; 12761501; 15461802; 14702039; 10591208; 15489334; 3065332; 12665801; 3611046; 1386213; 2383549; 7501023; 10369126; 10764829; 11146440; 14617626; 19497882; 19608861; 21269460; 22905912; 22223895; 22814378; 2313
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Function Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Subcellular Location Secreted, extracellular space, extracellular matrix
Tissue Specificity Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamnioti
Database Links

HGNC: 6561

OMIM: 150570

KEGG: hsa:3956

STRING: 9606.ENSP00000215909

UniGene: Hs.445351

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