Recombinant Human Galectin-1 protein(LGALS1) (Active)

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Code CSB-AP000471HU
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Product Details

Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human blood monocytes is in a concentration range of 1.0-10 ng/ml.
Target Names LGALS1
Uniprot No. P09382
Research Area Cancer
Alternative Names 14 kDa laminin-binding protein; 14 kDa lectin; Beta galactoside binding lectin; Beta galactoside binding lectin L 14 I; beta galactoside binding protein; Beta-galactoside-binding lectin L-14-I; DKFZp686E23103; Gal 1; Gal-1; GAL1; Galaptin; Galbp; Galectin; Galectin-1; Galectin1; GBP; HBL; HLBP14; HPL; L 14.5; L-14.5; L14; Lactose binding lectin 1; Lactose-binding lectin 1; Lect14; Lectin galactoside binding soluble 1; Lectin galactoside-binding soluble 1; LEG1_HUMAN; LGALS 1; LGALS1; Lgals1 lectin galactose binding soluble 1; MAPK activating protein MP12; Putative MAPK activating protein MP12 ; Putative MAPK-activating protein PM12; S Lac lectin 1; S-Lac lectin 1
Species Homo sapiens (Human)
Source E.Coli
Expression Region 2-135aa
Mol. Weight 14.6 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 150mM NaCl
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Gene References into Functions
  1. Silencing Gal-1 impaired invasiveness, and decreased S1PR1 expression and overexpression in gastric cancer can promote the expression of S1PR1and invasion of gastric cancer cells. PMID: 30453284
  2. Association of galectin-1 expression with eosinophilic infiltration of the tumor tissue in stomach and colorectal cancer was detected. PMID: 29926280
  3. Study shows that recombinant Galectin-1 (Gal-1) could promote the differentiation and invasion of Trophoblast stem cells (TSCs), suggesting that some of Ishikawa cells secretion increase the expression of Gal-1 in TSCs during implantation, which then induced trophoblast differentiation and invasion in vitro. PMID: 28826368
  4. In conclusion, these findings suggest that the serum levels of Gal-1, Gal-3, and Gal-9 may be associated with large artery atherosclerotic stroke. PMID: 28112232
  5. High LGALS1 expression is associated with fibrosis in chronic pancreatitis and pancreatic cancer. PMID: 29328490
  6. Pancreatic stellate cells promote cancer proliferation, migration, and invasion via Gal1-driven pathways. Gene-expression analyses of pancreatic tumor cells exposed to Gal1 reveal modulation of multiple regulatory pathways involved in tumor progression. PMID: 29615514
  7. Studies indicate tumor-derived galectin-1, galectin-3 and galectin-9 in various cancers and anticancer therapies that target these molecules [Review]. PMID: 29389859
  8. The expression level of galectin-1 affects survival in patients with glioblastoma multiforme treated with adjuvant radiotherapy PMID: 29378529
  9. Results show that Galectin-1 teams up with Galectin-3 to induce inflammatory/pro-degradative gene signature in human chondrocytes affecting the progression of osteoarthritis. Also, Galectin-3 was found to induce a pro-degradative-inflammatory gene signature in human chondrocytes, teaming up with Galectin-1 in the pathogenesis of osteoarthritis. PMID: 27982117
  10. We also found a subset of prostate cancer patient-derived xenografts and prostate cancer patient samples with mild HO-1 and low Gal-1 expression levels. These results highlight a novel function of a human-used drug as a means of boosting the antitumor response PMID: 28512172
  11. Gal-1, Gal-3 and Gal-9 galectin expression was higher in the myenteric plexus ganglia of chagasic patients PMID: 28554765
  12. Results have shown that Gal-1 in the farnesyl-bound form acquires the ability to form self-clusters, and the galactoside-binding pocket of Gal-1 in the FTS-bound form plays an important role in self-cluster formation. PMID: 27624845
  13. Our findings support the introduction of galectin-1 as a reliable diagnostic marker for thyroid carcinomas. Its involvement in cell proliferation, migration, invasion and tumor growth also intimate functional involvement of galectin-1 in the progression of thyroid carcinoma, suggesting its potential as a therapeutic target PMID: 28677745
  14. This study showed that obese children had significantly higher galectin-1 levels in proportion to fat mass in obese cases than those in healthy children, which may be interpreted as a compensatory increase in an attempt to improve glucose metabolism. PMID: 28728946
  15. We further demonstrated using the NMR-based hydrogen-deuterium exchange (HDX) that lactose binding increases the exchange rates of residues located on the opposite side of the ligand-binding pocket for hGal1 and hGal8(NTD), indicative of allostery. Additionally, lactose binding induces significant stabilisation of hGal8(CTD) across the entire domain PMID: 28813004
  16. our findings indicate that galectin-1 plays a pivotal role in the regulation of key processes in cancer cells, such as migration, invasion, and chemoresistance, by modulating FAK and ERK signaling and survivin level. PMID: 28415760
  17. Gal-3 staining in the nucleus could be a new positive prognosticator for ovarian cancer. PMID: 28594391
  18. Gal-1 may offer an additional therapeutic target linking anti-angiogenesis and immune checkpoint blockade. PMID: 28473314
  19. markedly increased brain Gal-1 and S-nitrosylated Gal-1 both in scrapie-infected rodents and human prion diseases. PMID: 27211330
  20. Gal-1 knockdown dramatically improved drug sensitivity of breast cancer by reducing P-glycoprotein (P-gp) expression via inhibiting the Raf-1/AP-1 pathway, providing a novel therapeutic target to overcome MDR in breast cancer. PMID: 28212576
  21. the immunosuppressive microenvironment promoted by hepatic stellate cell-derived galectin-1 in hepatocellular carcinoma can be inhibited by miR-22 PMID: 27494859
  22. Galectin-1 promotes invasion and epithelial mesenchymal transformation in gastric cancer cells via activation of the non-canonical Hh pathway in Gli-1 dependent manner. PMID: 27835885
  23. Gal-1 level retained independent predictive influence on the risk of developing cGvHD PMID: 27214079
  24. this study identified 131 Gal-3 and 15 Gal-1 interactors by galectin pulldown experiments combined with quantitative proteomics. PMID: 28576849
  25. we found that galectin-1 was a novel modulator of MDR1 by proteomic analysis of a model system of leukemia cell lines PMID: 27050374
  26. Data found Gal-1 to induce EMT and gastric cancer (GC) cell migration and invasion. Also, Gal-1 up-regulated Gli1 expression and beta1 integrin was responsible for Gal-1-induced Gli1 expression and EMT. PMID: 27836001
  27. Galectin-1-driven production of SDF-1 in pancreatic stellate cells through activation of NF-kappaB promotes metastasis in pancreatic ductal adenocarcinoma. PMID: 28336327
  28. Gal-1 expression by MM cells was upregulated in hypoxic conditions and stable knockdown of hypoxia inducible factor-1alpha significantly downregulated its expression PMID: 27311934
  29. Gal1 may be a useful marker for determining whether morphologic changes in oral cells are reactive or neoplastic PMID: 26980012
  30. The aim of this study was to analyze the syncytium formation abilities of BeWo cells that were gal-1 silenced. PMID: 26418280
  31. Studies provide evidence that galectin-1 belongs to the group of potential pathogenic molecules in systemic lupus erythematosus. [review] PMID: 28100106
  32. an intact dimer interface of Gal-1 is required for it to positively regulate H-rasG12V nanoclustering, but negatively K-rasG12V nanoclustering. PMID: 27087647
  33. Our results suggest that Gal-1 and ASPP2 functionally compete in nanocluster for active Ras on the plasma membrane. ASPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events. PMID: 27437940
  34. Galectin-1 and Galectin-3 are novel-binding partners for human FVIII. Gal-1 binding can influence the procoagulant activity of FVIII. PMID: 27013611
  35. Proteomics of the interstitial fluid in subcutaneous adipose tissue in vivo identified a novel adipokine, galectin-1, with a potential role in the pathophysiology of type 2 diabetes. PMID: 27282870
  36. Suggest that galectin-1 is a protective factor against the development of digital vasculopathy in systemic sclerosis. PMID: 24517166
  37. This study demonstrated that TLR-mediated PI3K activation modulated the invasion and metastasis of ovarian cancer through the production of galectin-1. PMID: 28350104
  38. Gal-1-regulated carcinoma-associated fibroblast activation promotes breast cancer cell metastasis by upregulating MMP-9 expression. PMID: 27025601
  39. It is a beta-galactose-binding animal lectin and known to be distributed throughout the body. PMID: 27590897
  40. Our functional analyses of galectin-1 in urinary bladder urothelial carcinoma provided novel insights into the critical role of galectin-1 in tumor progression and invasion. These results revealed that silencing the galectin-1-mediated MAPK signaling pathway presented a novel strategy for bladder cancer therapy. PMID: 27440446
  41. the TLR4/Gal-1 signaling pathway regulates lactate-mediated EMT processes through the activation of ADAM10 and ADAM17 in colon cancer cells. PMID: 27837433
  42. These findings suggest that Gal-1 plays an important role in immune escape of gingival squamous cell carcinoma cells, and Gal-1 expression level may be a useful clinicopathological prognostic marker for this cancer. PMID: 28108653
  43. Galectin-1 gene silencing would improve the sensitivity of A549/DDP cells to cisplatin in vivo and in vitro. PMID: 27392028
  44. In this study, gal-1, -2, -3 and -13 were investigated systematically in the trophoblast and decidua compartment of intrauterine growth restriction (IUGR) placentas and normal third trimester control placentas and stratified by fetal gender and gestational age. Gal-1 Expression Shows No Significant Changes in IUGR Placentas in Villous Trophoblasts. PMID: 27070577
  45. Galectin-1 overexpression activates the FAK/PI3K/AKT pathway by upregulating expression of alphavbeta3 integrin, leading to enhanced hepatocellular carcinoma invasion via epithelial-mesenchymal transition and sorafenib resistance. PMID: 27100895
  46. results show that HELLP syndrome is associated with increased circulating levels of gal-1 PMID: 26956510
  47. The integrative analysis of galectins(Gal-1, -3, -4, -9) discriminated IBD from other intestinal inflammatory conditions and could be used as potential mucosal biomarker PMID: 26891020
  48. Galectin-1 was undetectable in normal and ulcerative colitis colonic epithelium, while galectin-2, galectin-3, and galectin-4 were strongly expressed. PMID: 26885508
  49. Tumor-driven, unremitting expression of Satb1 in activated Zbtb46+ inflammatory dendritic cells that infiltrate ovarian tumors results in an immunosuppressive phenotype characterized by increased secretion of tumor-promoting Galectin-1 and IL-6. PMID: 26876172
  50. Epithelial immunostaining for galectin-1 tended to be elevated in fallopian tubes from women with ectopic pregnancy. PMID: 26359845
  51. results show that Gal-1 acts by inhibiting the stimulation of the LPS-induced IkappaBzeta expression, an NF-kappaB regulator involved in IL-6 gene transcription. PMID: 26226212
  52. Data suggest that galectin-1 and VEGFR-2 are expressed at mid-luteal stages in luteal cells of corpus luteum; galectin-1 binds directly to asparagine-linked glycans (N-glycans) on VEGFR-2 in luteal cells. PMID: 26155753
  53. LYAR may promote tumor cell migration and invasion by upregulating galectin-1 gene expression in colorectal cancer. PMID: 26413750
  54. Galectin-1 could predict more lymph node metastasis in colorectal cancer patients with normal serum carcinoembryonic antigen. PMID: 26448934
  55. Our results suggest that Gal1 and TGF-beta1 might function coordinately within the HCC microenvironment to regulate tumor growth, invasion, metastasis, and angiogenesis. PMID: 26551914
  56. the galectin expression profile of choriocarcinoma JAr cells and evaluation of the relative significance of LGALS1 for their in vitro invasiveness PMID: 26096842
  57. Galectin-1-Induced Autophagy Facilitates Cisplatin Resistance of Hepatocellular Carcinoma PMID: 26859293
  58. siRNA-mediated downregulation of galectin-1 caused apoptosis in HCC cells, which was coupled with reduced Bcl-2 and survivin and increased Bax expression. Knockdown of galectin-1 significantly enhanced TRAIL cytotoxicity against HCC cells. PMID: 26348206
  59. Galectin-1 protein is protective on in vivo and in vitro models of ocular inflammation. PMID: 26392742
  60. This study thus identifies Galectin-1 as a master regulator of clinically relevant inflammatory-response genes, working via NF-kappaB PMID: 26792806
  61. Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread PMID: 26759008
  62. galectin-1 and -3 are expressed by the human cervical and vaginal epithelial cells and act as pathogen-recognition receptors for the ceramide phosphoinositol glycan core (CPI-GC) of the dominant surface protozoan lipophosphoglycan. PMID: 26589797
  63. Suggest that galectin-1 plays a major role on the tumorigenesis and invasiveness of CD133+ lung adenocarcinoma cells. PMID: 25605013
  64. GAL1/pre-B-cell receptor interaction modifies GAL1/glycan affinity and particularly inhibits binding to LacNAc containing epitopes PMID: 25708191
  65. These results suggest that galectin-1 is a possible biomarker for predicting the response of hepatocellular carcinoma patients to treatment with sorafenib PMID: 25850433
  66. no difference in cord blood concentration correlated with restricted or increased fetal growth PMID: 24717333
  67. study elucidates the specificity of Gal-3BP interacting with galectin-1 and the role of Gal-3BP in cancer cell aggregation and metastasis PMID: 26168351
  68. galectin-1 and Treg cells may play essential roles in maintaining a normal pregnancy and their reduction may involve in the pathogenesis of unexplained recurrent spontaneous abortion. PMID: 25973091
  69. Gal1 and gal3 regulate the inflammatory response in airway epithelial cells exposed to microbial neuraminidase by modulating the expression of SOCS1 and RIG1. PMID: 26355912
  70. Lower LGALS1 gene expression is associated with acute myeloid leukemia. PMID: 25953264
  71. These findings define a novel role for galectin-1 in inhibiting tissue emigration of immunogenic, but not tolerogenic, dendritic cells, providing an additional mechanism by which galectin-1 can dampen immune responses. PMID: 26216879
  72. Data indicate that O-glycan-specific alpha2,6 sialyltransferase regulate cancer growth and metastasis by regulating galectins Gal-1- and Gal-3-binding moieties on O-glycans. PMID: 26224120
  73. functional variants of LGALS1 causing the expression variations are contributable to the differential susceptibility to influenza A(H7N9). PMID: 25687228
  74. These results suggested a novel role of inGal-1 in T-cells as a regulator of T-cell response to exGal-1, and its likely contribution to the mechanism in T-cell apoptosis deficiency in lupus. PMID: 25468561
  75. Serum levels of gal-1 and gal-3 may serve as plausible markers for oral squamous cell carcinoma and may be useful in screening population at a higher risk PMID: 25578395
  76. Galectin-1 is upregulated in stable liver transplant recipients. Results extend the recent findings that galectin-1 may play an immune-suppressive role in liver transplantation. PMID: 25645780
  77. hCaPSC-derived galectin-1 enhanced apoptosis and anergy of T cells in pancreatic cancer, which contributes to the immune escape of pancreatic cancer cells. PMID: 25725585
  78. trophoblast mucin(s) could act as binding partners of galectin-1, in a carbohydrate-dependent manner PMID: 24854997
  79. Malignant transformation is frequently associated with altered galectin expression, most notably of galectin-1 and galectin-3. PMID: 25819524
  80. Galectin-1 contributes to resistance of macrophages to in vitro-infection with DENV-1 and it is also important to physiological susceptibility of mice to in vivo infection with DENV-1 PMID: 25392933
  81. Data indicate that complex low density lipoprotein (LDL) could attach through lipoprotein(a) Lp(a) to immobilized form of galectin-1. PMID: 25142165
  82. current study confirms the prognostic value of galectin-1 and identifies galectin-9Delta5 as novel potential prognostic markers in early stage NSCLC. PMID: 25259711
  83. GCSF inhibits IL10induced apoptosis, implying that galectin1 may enhance the immunemodulating functions of GCSF by inducing tolerogenic dendritic cells and maintaining their survival. PMID: 25231117
  84. Gal-1 has a role in increasing vascular permeability through the NRP-1/VEGFR1 and Akt signaling pathway PMID: 24719187
  85. Gal-1, 2, and 3 levels were high in maintenance hemodialysis patients. Kidney transplantation improved gal-1, 2, and 3 levels. PMID: 24984218
  86. Knockdown of GAL1 inhibits growth and invasion of osteosarcoma cells possibly through inhibition of the MAPK/ERK pathway. High expression of GAL1 is associated with distant metastasis in OS patients. PMID: 25069486
  87. the first evidence of a role of Galectin-1 as an inducer of epithelial-mesenchymal transition in hepatocellular carcinomas cells, with critical implications in hepatocellular carcinomas metastasis PMID: 25469885
  88. We have previously reported on the role of galectin-1 and -9 in endothelial cell function. Here, we review the current knowledge of these two galectins in endothelial cell biology and angiogenesis. PMID: 24861051
  89. Targeting Gal-1 in combination with radiotherapy provides an exciting approach to address several radiation-prohibitive mechanisms PMID: 24973253
  90. Authors demonstrate that galectin-1 can enhance Nipah virus attachment to and infection of primary human endothelial cells by bridging glycans on the viral envelope to host cell glycoproteins. PMID: 25505064
  91. structure and function of galectin-3 in neuroblastoma cell growth regulation PMID: 24909114
  92. These findings indicate that galectin-1 is a key regulator of wound repair that has therapeutic potential for pathological or imperfect wound healing. PMID: 25007042
  93. We used an organotypic model of cutaneous T-cell lymphoma to show that malignant T cells through the secretion of galectin-1 and -3 stimulate vigorous growth of keratinocytes. PMID: 25007045
  94. The results showed that high expression of Gal-1 in carcinoma-associated fibroblasts might facilitate gastric cancer cell migration and invasion by upregulating integrin beta1 expression in gastric cancer. PMID: 25230369
  95. gestational diabetes is associated with a failure to increase circulating gal-1 levels during the second and third trimester, and overexpression of gal-1 in placenta. LGALS1 polymorphism was associated with the development of gestational diabetes. PMID: 24637109
  96. Galectin-1 expression in stromal cells of pancreatic cancer suggests that this protein plays a role in the promotion of cancer cells invasion and metastasis. PMID: 24595374
  97. overexpression associated with shorter survival in nasopharyngeal carcinoma PMID: 24646142
  98. These results underline the essential role of Gal-1 during endometriosis PMID: 24979200
  99. both the AnxA1 and Gal-1 anti-inflammatory proteins are deregulated in precancerous gastric lesions PMID: 24719523
  100. Apoptosis of regulatory T cells induced by galectin-1 is accompanied by an increase in the content of proapoptotic protein Bad. PMID: 24770755

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Subcellular Location Secreted, extracellular space, extracellular matrix
Tissue Specificity Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamnioti
Database Links

HGNC: 6561

OMIM: 150570

KEGG: hsa:3956

STRING: 9606.ENSP00000215909

UniGene: Hs.445351

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