Recombinant Human Sonic hedgehog protein(SHH),partial (Active)

In Stock
Code CSB-AP000371HU
Product Type Other
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q15465
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered 20 mM PB, pH 7.4, 150mM NaCl ,lyophilized
Alias SHH
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by inducing alkaline phosphatase production of murine C3H/10T1/2 cells is less than 1 μg/ml, corresponding to a specific activity of >1.0x103 IU/mg.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence IVIGPGRGFG KRRHPKKLTP LAYKQFIPNV AEKTLGASGR YEGKISRNSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDKLNALAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRAVDITTS DRDRSKYGML ARLAVEAGFD WVYYESKAHI HCSVKAENSV AAKSGG
Research Area Cancer
Source E.coli
Gene Names SHH
Expression Region 22-197aa
Tag Info Tag-Free
Mol. Weight 19.8 kDa
Protein Description Partial(22-24:LAC→IVI)
PubMed ID 7590746; 12853948; 12690205; 9593755; 7720571; 12837695; 16335952; 18417549; 19847792; 24456159; 24965254; 10753901; 19561609; 20504762; 8896572; 9302262; 10441331; 10556296; 11471164; 11479728; 12503095; 15103725; 15107988; 15221788; 15942952; 15942953;
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Function Sonic hedgehog protein
Involvement in disease Microphthalmia, isolated, with coloboma, 5 (MCOPCB5); Holoprosencephaly 3 (HPE3); Solitary median maxillary central incisor (SMMCI); Triphalangeal thumb-polysyndactyly syndrome (TPTPS); Preaxial polydactyly 2 (PPD2); Hypoplasia or aplasia of tibia with polydactyly (THYP); Laurin-Sandrow syndrome (LSS)
Subcellular Location Sonic hedgehog protein N-product: Cell membrane, Lipid-anchor
Protein Families Hedgehog family
Database Links

HGNC: 10848

OMIM: 135750

KEGG: hsa:6469

STRING: 9606.ENSP00000297261

UniGene: Hs.164537

Pathway Hedgehog signaling pathway

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