ADAM12 Antibody, FITC conjugated

Code CSB-PA001275LC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ADAM12 Polyclonal antibody
Uniprot No. O43184
Target Names ADAM12
Alternative Names A disintegrin and metalloproteinase domain 12 antibody; ADA12_HUMAN antibody; ADAM 12 antibody; ADAM metallopeptidase domain 12 antibody; ADAM12 antibody; CAR10 antibody; Disintegrin and metalloproteinase domain-containing protein 12 antibody; MCMP antibody; MCMPMltna antibody; Meltrin alpha antibody; Meltrin-alpha antibody; Metalloprotease disintegrin 12 transmembrane antibody; MLTN antibody; MLTNA antibody; OTTHUMP00000046766 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Disintegrin and metalloproteinase domain-containing protein 12 protein (730-909AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
Gene References into Functions
  1. our study provide crucial evidence that ADAM12 induces epithelial to mesenchymal transition and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway PMID: 29136943
  2. This meta-analysis suggests that the ADAM 12 genetic polymorphisms rs1871054 and rs1044122 might be associated with risk of knee osteoarthritis; rs3740199 might be associated with risk of knee osteoarthritis in men. PMID: 28748424
  3. Data report that ADAM12 is upregulated in the vessels of aggressive breast tumors and exerts key regulatory functions. Also, its expression is significantly positively correlated with pro-angiogenic factors including VEGF and MMP-9 but negatively associated with TSP1. These findings suggest that ADAM12 regulates endothelial cell function and facilitates a proangiogenic microenvironment in a STAT3-dependent manner. PMID: 28765266
  4. Results suggest that ADAM12 gene is a susceptibility gene underlying both joint destruction and growth retardation of the Kashin-Beck disease (KBD). PMID: 27545300
  5. ADAM12 is induced by Twist1 and plays a crucial role in tumor invasion and metastasis by regulating both invadopodia and focal adhesions PMID: 28468988
  6. statistically significant association between rs1871054 and risk of Knee Osteoarthritis in Asian population; other polymorphisms (rs3740199, rs1044122, or rs1278279) in ADAM12 were not associated with Knee Osteoarthritis in any population (Meta-Analysis). PMID: 28929114
  7. rs3740199 polymorphism does not contribute to the development of knee osteoarthritis [meta-analysis] PMID: 28637509
  8. Tetraspanin-8 has a role in promoting hepatocellular carcinoma metastasis by increasing ADAM12m expression PMID: 27270327
  9. A novel regulator, myoferlin, of ADAM12 is discovered in HeLa cells and this protein increases ADAM12 expression level, stability, and its enzymatic activity, leading to the reduction of its substrate, E-cadherin, which plays important roles in the regulation of cell adhesion and tumor metastasis. PMID: 27432471
  10. Our data support a role for ADAM12 in NHL cell proliferation, adhesion, and drug resistance, and it may pave the way for a novel therapeutic approach for CAM-DR in NHL. PMID: 28395594
  11. The rs3740199 polymorphism in the ADAM12 gene was associated with knee osteoarthritis genetic susceptibility. PMID: 26875044
  12. These results indicate that ADAM12 actively supports the CSC phenotype in claudin-low breast cancer cells via modulation of the EGFR pathway. PMID: 28148288
  13. We conclude that ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas, which qualifies these proteins in diagnosis and therapy. PMID: 27144841
  14. ADAM12 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
  15. Stromal expression patterns for both ADAM12 and CDCP1. PMID: 27685922
  16. The first trimester maternal ADAM12-s levels were statistically significantly higher in the entire ART group, IVF and ICSI groups, and normal cycle-frozen embryo transfer group when compared with those in the controls. PMID: 26697810
  17. The level of ADAM12 was upregulated in tumor tissues of breast cancer compared to that of adjacent normal tissues. patients with higher level of ADAM12 exhibited shorter survival time compared to that of low level of ADAM12 PMID: 26722530
  18. The siRNA-directed loss of ADAM12 impedes spontaneous fusion of primary cytotrophoblasts, whereas overexpression of the secreted variant, ADAM12S, potentiates cell fusion in the Bewo trophoblast cell line. PMID: 25909890
  19. the present findings support the conclusion that the E2F1 transcription factor regulates the expression of ADAM12 by binding differential cis-acting elements. PMID: 26503019
  20. ADAM12L is associated with epithelial to mesenchymal transition (EMT) and contributes to TGF-beta-dependent EMT. PMID: 26407179
  21. ADAM33 and ADAM12 genetic polymorphisms and their expression in Egyptian children with asthma PMID: 26553447
  22. Data suggest that low serum levels of ADAM12/hCG may be biomarkers in diagnosis of continued incomplete spontaneous abortion; here, ADAM12/hCG indicate success/failure of single dose of misoprostol/oxytocic in treatment of early pregnancy failure. PMID: 26051455
  23. The ADAM12-L 3'UTR is a direct target of miR-29 and miR-200 family members. PMID: 25886595
  24. High urine ADAM12 levels are associated with gastric cancer. PMID: 25591790
  25. Studied the potential role of four SNPs of the ADAM12 gene in susceptibility to knee osteoarthritis and its progression in Chinese Han population. PMID: 25667922
  26. There is a difference between the genders in response to an adverse maternal environment and suggest that an alteration in ADAM12 may reflect an altered placental response in pregnancies subsequently complicated by preeclampsia. PMID: 24899472
  27. ADAM12 expression is associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma.High serum protein levels of ADAM12 are associated with poor survival in patients with high-grade serous ovarian carcinoma. PMID: 25926422
  28. the ADAM12 rs1871054 variant was found to be significantly associated with increased knee osteoarthritis susceptibility in a Chinese Han population PMID: 25197389
  29. Data show that ADAMTS1 was expressed at a significantly higher level in extravillous trophoblast cells (EVTs) than in villous trophoblast cells (VTs), while both ADAM10 and ADAM12 were expressed at significantly higher levels in VTs than in EVTs. PMID: 24998958
  30. High ADAM12 expression is associated with prostate cancer. PMID: 25139103
  31. Data confirms activity of trophoblast-derived ADAM12S by demonstrating its potential to degrade insulin-like growth factor-binding protein 3. ADAM12S exerts pro-migratory function in trophoblasts by inducing integrin beta 1-mediated cellular spreading. PMID: 24695627
  32. ADAM12 expression in the first trimester of pregnancy may have a role in complete spontaneous abortion and hydatidiform mole PMID: 24830297
  33. IHC revealed protein expression of all four genes. IHC staining for ADAM12, FAP, and WISP1 correlated with CDR and was higher, whereas SOX11 staining was lower in tumors with earlier recurrence following excision PMID: 24402778
  34. ADAM-12 is an independent prognostic factor and diagnostic marker, and is involved in the proliferation, invasion and metastasis of small cell lung cancer . PMID: 24465799
  35. This apparent association between the catalytic activity of the mutants and the type of breast cancer supports a previously postulated role of an active ADAM12-L in the triple negative breast cancer disease. PMID: 24651654
  36. Studied the splicing variants of ADAM12 (L and S) and ADAM17 gene expression in melanoma at transcriptional and translational level in comparison with control (non-tumor) tissues. PMID: 23645517
  37. ADAM12 localizes to invasive trophoblast, promotes cell invasion and directs column outgrowth in early placental development. PMID: 24243624
  38. findings suggest that urinary ADAM 12 may not correlate directly with the status and stage of breast cancer as previously thought; rather these increases may be a result of tissue injury and inflammation from biopsy and surgical resection PMID: 24690292
  39. ADAM12 is upregulated in the synovial tissue during synovitis on mRNA and protein level. and could have a role in knee osteoarthritis synovitis, especially in the occurrence of postinflammatory fibrosis. PMID: 23578941
  40. Data suggest that a ternary protein complex composed of ADAM12, alphaVbeta3 integrin and MMP-14 at the tumor cell surface regulates the function of MMP-14. PMID: 24006261
  41. growth factor-like growth factor(HB-EGF) are involved in cellular plasticity resulting in production of brown adipose tissue-like cells PMID: 24116709
  42. Genotype frequency is not significant among ADAM12, within the combined South African and Australian control and Achilles tendon pathology (ATP) groups. PMID: 23491141
  43. up-regulation of the ADAM12 ADAM12L isoform in claudin-low breast tumors and during epithelial-to-mesenchymal transition PMID: 23771733
  44. understanding of ADAM12 both as a biomarker and a potential drug target could help make significant inroads into both early diagnosis and treatment of disease PMID: 23680494
  45. ADAM 12 is highly expressed in, but not restricted to, oligodendrogliomas PMID: 23324579
  46. Although no significant correlations were seen between E2 and PIGF or P4 and ADAM12 in women in the early stages of IUP, E2 was positively correlated with PIGF and P4 was positively correlated with ADAM12 in women with EP prior to tubal surgery PMID: 23421942
  47. The associations of two single-nucleotide polymorphisms (GDF5 and ADAM12) with knee osteoarthritis that were noted in previous studies, were not found in the Korean knee osteoarthritis cohort. PMID: 22284607
  48. A role is demonstrated for ADAM12 in ectodomain shedding of membrane-anchored endothelial proteins in the tumor vasculature, an important process in tumor neovascularization and tumor cell extravasation. PMID: 23458101
  49. Hypoxia increased the levels and activity of the ADAM12 metalloprotease in a Notch signaling-dependent manner, leading to increased ectodomain shedding of the epidermal growth factor (EGF) receptor (EGFR) ligand heparin-binding EGF-like growth factor. PMID: 23589494
  50. ADAM12 is the primary protease responsible for the activation of EGFR in early stage, lymph node-negative triple-negative breast cancers PMID: 22926263
  51. Our findings unveil a new epigenetic regulatory process in which Z-DNA/MeCP2/NF1 interaction leads to transcriptional suppression, loss of which results in ADAM-12 overexpression in breast cancer cells. PMID: 23135915
  52. Conditioned medium from A549 human lung adenocarcinoma cells induced the expression of ADAM12, a disintegrin and metalloproteases family member, in human adipose tissue-derived mesenchymal stem cells. PMID: 22903068
  53. significantly decreased in severe and mild preeclampsia and is correlated with cerebroplacental ratio, severity of preeclampsia, maternal complications, and fetal outcome [review] PMID: 22676623
  54. Proline rich domain of ADAM12 interacts with the adaptor protein growth factor receptor-bound protein 2 (Grb2). PMID: 22882974
  55. Our data suggest a new role for ADAM12L in mediating the functional association of ILK with beta1 integrin to regulate cell adhesion/survival through a PI3K/Akt signaling pathway. PMID: 22767580
  56. ADAM-12 levels had limited value as a diagnostic biomarker for ectopic pregnancy PMID: 22927907
  57. These results suggest a pivotal role for lipid raft-associated ADAM12 in the TGF-beta1-induced differentiation of human adipose tissue-derived mesenchymal stem cells into smooth muscle cells. PMID: 22808268
  58. ADAM12 p.L792F mutation is unlikely to be a driver (cancer causing)-mutation in breast cancer. PMID: 22662180
  59. ADAM12-S protein is involved in the pathogenesis of knee osteoarthritis (KOA) and can be elevated in some KOA cases. PMID: 21258805
  60. The median multiple of the median (MoM) value of ADAM12-S in Down Syndrome pregnancy group was higher than that of the control group (P< 0.01). PMID: 22678798
  61. Data indicate that ADAM12 is overexpressed in oral squamous cell carcinoma and might accelerate cellular proliferation. Its function may be associated with TGF-beta3 signaling. PMID: 22267082
  62. Observation that ADAM12 expression is significantly higher in the terminal duct lobular units adjacent to breast carcinoma compared with TDLUs found in normal breast tissue supports our hypothesis that tumor-associated stroma triggers ADAM12 expression. PMID: 21875931
  63. Significantly elevated amounts of ADAM12L, ADAM12S and ADAM17 transcripts were found in malignant breast cells compared with normal breast tissue. PMID: 21501859
  64. Data show that elevated levels of matrix metalloproteinase-7 (MMP7) and a disintegrin and metalloproteinase-12 (ADAM12) in alpha(1a)-247R-expressing cells are responsible for EGF receptor (EGFR) transactivation. PMID: 22089237
  65. secretion of PAPP-A, ADAM12 and PP13 is closely related to the size of the placenta in the beginning of pregnancy. After 8 weeks of pregnancy, which is the time for luteoplacental shift, the correlation disappears. PMID: 22015022
  66. ADAM12 is selectively expressed in ovarian tumor vasculature PMID: 21617380
  67. This study confers further evidence regarding the role of ADAM12 and 17 in the breast tumorigenesis and progression. PMID: 21240579
  68. Notch up-regulates the expression of the long form, but not the short form, of ADAM12 containing a divergent 3'-untranslated mRNA region PMID: 21518768
  69. ADAM12 overexpression results in increased tumor take, tumor size, and metastasis in vivo. These findings suggest that ADAM12 may represent a potential therapeutic target in breast cancer. PMID: 21493715
  70. The different localisation of ADAM12-S and ADAM12-L indicates a possible different role making ADAM12-L a candidate for the fusion event, while the syncytial localisation of the ADAM12-S makes it a candidate for cell-cell and cell-matrix interactions. PMID: 21330122
  71. ADAM metalloproteinase 12 is a promising marker for the diagnosis of ectopic pregnancy with symptoms in the first trimester. PMID: 21277576
  72. Spliced variants ADAM12L and 12S expression were significantly up-regulated in breast cancers, while in the normal breast, we found a very low expression. PMID: 21103624
  73. This study identified a cellular mechanism for induction of ADAM-12, which involves NF-kappaB and its activation by TGF-beta1. PMID: 20688878
  74. Z-DNA-forming transcriptional repressor elements, by interacting with Z-DNA-binding proteins, are involved in the maintenance of constitutive low-level expression of human ADAM-12. PMID: 21173277
  75. Including ADAM12-S in the routine risk does not improve the performance of first trimester screening for fetal trisomy 21. PMID: 21034452
  76. ADAM12 MoM levels in Euploidy and Trisomy 21 pregnancies were not statistically different. PMID: 20230315
  77. a possible link between paternal schizophrenia and low birthweight might be existing through reduced ADAM12 expression levels PMID: 20305677
  78. ADAM12 may be unstable under many routine laboratory conditions. PMID: 20509156
  79. ADAM12 can be used as an effective second-trimester serum marker for prenatal screening of Down syndrome. PMID: 20509157
  80. The endogenous SnoN plays a role in regulating ADAM12 expression in response to TGFbeta1. PMID: 20457602
  81. increased first-trimester levels of ADAM-12 in pre-eclampsia and HELLP syndrome. PMID: 20090292
  82. Median ADAM12s MoM in euploid twins was increased compared with singletons. PMID: 20187159
  83. A significantly reduced numerical density of ADAM12 immunoreactive oligodendrocytes was found in the white matter of the anterior cingulate cortex of schizophrenic patients. PMID: 20218926
  84. Our data do not support the existence of an interaction between rs11244787 in ADAM12 and rs3740473 in SH3PXD2A in terms of the risk of AD. PMID: 19837132
  85. Activated c-Src binds, phosphorylates, and redistributes ADAM12-L to specific sites at the cell periphery, which may in turn promote signalling mechanisms regulating cellular processes with importance in cancer. PMID: 19769962
  86. in liver cancers ADAM12 expression is associated with tumor aggressiveness and progression. PMID: 12717386
  87. surface expression of ADAM12 alters the organization of the actin cytoskeleton and extracellular matrix PMID: 12915587
  88. ADAM12 has a role in proHB-EGF shedding induced by TPA and angiotensin II requires PACSIN3 as an upregulator PMID: 12952982
  89. The interaction between ADAM12 and integrin alpha7beta1 may be relevant to muscle development, function, and disease. We also conclude that laminin and the DC domain of ADAM12 represent two functional ligands for integrin alpha7beta1. PMID: 15242759
  90. Expression in human colonic cell lines. PMID: 15358598
  91. PKCepsilon plays a critical role in the regulation of ADAM12 cell-surface expression PMID: 15364951
  92. ADAM 12 is a gelatinase, it can be detected in breast cancer patient urine, and increased urinary levels of this protein correlate with breast cancer progression PMID: 15381692
  93. ADAM12m is highly expressed in human glioblastomas and may play a role in the prominent proliferation of the glioblastomas through shedding of heparin-binding epidermal growth factor PMID: 15509542
  94. ADAM12 is instrumental in myogenic cell differentiation. PMID: 15574885
  95. ADAM12 increases the apoptotic sensitivity of nonneoplastic cells in vitro while rendering tumor cells more resistant to apoptosis. PMID: 15930294
  96. p70 s6 kinase is involved in upregulation of ADAM12 gene expression associated with hepatic stellate cell activation during liver injury contributing to liver fibrosis and liver tumor progression. PMID: 16139919
  97. Cells deficient in beta1 integrin or overexpressing beta3 integrin can bind human ADAM12 via beta3 integrin. PMID: 16213489
  98. the prodomain of human ADAM12-S is an integral domain of the mature molecule and as such might have specific biological functions in the extracellular space PMID: 16455653
  99. results provide evidence for an overexpression of ADAM-12 and a lower expression of ADAMTS-1 in non-small-cell lung cancer suggest that these proteases play different functions in cancer progression PMID: 16495931
  100. ADAM12-S stimulates bone growth by modulating chondrocyte proliferation and maturation through mechanisms probably involving both metalloprotease and adhesion activities. PMID: 16869727

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Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Isoform 3: Secreted, SUBCELLULAR LOCATION: Isoform 4: Secreted
Tissue Specificity Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancre
Database Links

HGNC: 190

OMIM: 602714

KEGG: hsa:8038

STRING: 9606.ENSP00000357668

UniGene: Hs.594351

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