CASR Antibody

Datasheet
Code CSB-PA004558GA01HU
Size US$685
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Product Details

Uniprot No. P41180
Target Names CASR
Alternative Names Ca sensing receptor antibody; Ca2+ sensing receptor 1 antibody; Ca2+ sensing receptor antibody; Calcium sensing receptor antibody; CAR antibody; CaSR antibody; CASR_HUMAN antibody; EIG8 antibody; Extracellular calcium sensing receptor antibody; Extracellular calcium sensing receptor [Precursor] antibody; Extracellular calcium-sensing receptor antibody; FHH antibody; FIH antibody; GPRC2A antibody; HHC antibody; HHC1 antibody; Hypocalciuric hypercalcemia 1 antibody; Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism antibody; MGC138441 antibody; NSHPT antibody; Parathyroid Ca(2+) sensing receptor 1 antibody; Parathyroid Cell calcium sensing receptor antibody; Parathyroid Cell calcium-sensing receptor antibody; PCAR 1 antibody; PCaR1 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human CASR
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis
Gene References into Functions
  1. Performed cytogenetic analysis in 23 patients with Sagliker syndrome; found base alterations and deletions in exons 2 and 3 of the calcium sensing receptor (CaSR) gene. PMID: 28263480
  2. Based on these findings, ischemia/reperfusion-induced MCPIP1 expression regulates the migration and apoptosis of human vascular endothelial cells via HMGB1 and CaSR, respectively. PMID: 29379093
  3. expressions of p27(Kip1) and CaSR were decreased in primary hyperparathyroidism patients PMID: 29589297
  4. Study presents the novel concept that CaSR activation stimulates autophagy in preadipocytes, which in turn mediates the elevation of TNFalpha production. PMID: 30251678
  5. The identification of the activation of CaSR-mediated protective pathway in renal cells sheds light on a possible cellular protective mechanism against Cd-induced kidney injury. PMID: 29348484
  6. These findings suggest an inhibitory role for CaSR in endometrial cancer. Therefore, reduced CaSR expression may be a suitable explanation and valuable predictor for endometrial cancer progression. PMID: 29348629
  7. We found that subjects carrying the G allele of rs6776158 (AG and GG) had significantly higher risk of nephrolithiasis compared to the AA genotype.Our results indicate that rs6776158 polymorphism that might elevate the risk of nephrolithiasis in the Chinese population. PMID: 30407299
  8. The variant allele of CASR rs1801725 solely and together with the variant allele of rs7652589 increases risk of more advanced secondary hyperparathyroidism. PMID: 29763933
  9. findings confirm the expression of CaSR in human BM-derived MSCs and unravel a prominent role for the interplay between CaSR and PTH1R in regulating MSC fate and the choice of pathway for bone formation. PMID: 29915064
  10. Genetic polymorphism of calcium-sensing receptor is associated with breast cancer. PMID: 29387985
  11. The low prevalence of CaSR autoantibodies indicate a very low level of subclinical parathyroid autoimmunity in APS types 2, 3 and 4. PMID: 28941288
  12. CaSR Arg990Gly polymorphism is associated with the risk of nephrolithiasis development in a Chinese population. PMID: 28609763
  13. TRPC1 is a primary candidate in forming SOCC that stimulates CaSRinduced SOCE and NO production in HUVECs PMID: 28791397
  14. The c.2195A>G, p.(Asn732Ser) mutation in exon 7 of the CaSR gene leads to hypocalcaemia, and has not been reported before in the medical literature. 2) Possibly, this mutation is linked to premature baldness. PMID: 28741586
  15. CASR SNPs may partly explain differences in the clinical manifestations of CKD-MBD between european and African ancestry populations, and in the biochemical response to cinacalcet in many patients. PMID: 28630081
  16. Decreased sensitivity of the CaSR to calcium due to inactivating polymorphisms at rs1801725, may predispose up to 20% of breast cancer cases to high circulating calcium-associated larger and/or aggressive breast tumors. PMID: 28764683
  17. This study shows that the A allele of rs7652589 is a risk allele for nephrolithiasis-related end stage renal disease. The AA genotype is associated with more severe secondary hyperparathyroidism (higher calcium and parathormone concentrations). PMID: 27739473
  18. Polymorphism of the Calcium-Sensing Receptor Gene is associated with Breast Cancer Risk.[review] PMID: 29504802
  19. Data show that Cao2+ via CaR- mediated signaling induces filamin A cleavage and promotes the migration in AR-deficient and highly metastatic prostate cancer cells. PMID: 27206800
  20. GPR64 is expressed on the cell surface of parathyroid cells, is overexpressed in parathyroid tumors, and physically interacts with the CaSR. PMID: 27760455
  21. this study, demonstrates for the first time that calcium exerts an oncogenic action in the stomach through activation of CaSR and TRPV4 channels. Both CaSR and TRPV4 were involved in Ca2+-induced proliferation, migration, and invasion of gastric cancer cells through a Ca2+/AKT/beta-catenin relay, which occurred only in gastric cancer cells or normal cells overexpressing CaSR. PMID: 28951460
  22. mutagenesis with a novel analytical approach and molecular modeling to develop an "enriched" picture of structure-function requirements for interaction between Ca(2+)o and allosteric modulators within the CaSR's 7 transmembrane (7TM) domain, is reported. PMID: 27002221
  23. FLNA is downregulated in parathyroid tumors and parallels the CASR expression levels. Loss of FLNA reduces CASR mRNA and protein expression levels and the CASR-induced ERK phosphorylation. FLNA is involved in receptor expression, membrane localization and ERK signaling activation of both 990R and 990G CASR variants. PMID: 27872158
  24. A father and daughter with asymptomatic chronic hypocalcemia with low parathyroid hormone and inappropriate urinary calcium excretion had a missense mutation in exon 7: c.2621G>T (p.Cys874Phe). PMID: 27663953
  25. These results support the emerging potential of CaSR as a therapeutic target in metastatic breast cancer whose pharmacological modulation would reduce IL-6. PMID: 27477783
  26. These structures reveal multiple binding sites for Ca(2+) and PO4(3-) ions. Both ions are crucial for structural integrity of the receptor. While Ca(2+) ions stabilize the active state, PO4(3-) ions reinforce the inactive conformation. PMID: 27434672
  27. The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor. PMID: 28419469
  28. Glucose acts as a positive allosteric modulator of CaSR. PMID: 27613866
  29. These studies indicate that the CaSR activation impairs glucose tolerance by a combination of alpha- and beta-cell defects and also influences pancreatic islet mass. PMID: 28575322
  30. Minor alleles rs7652589 and rs1501899 are associated with reduced CaSR expression in neuroblastic tumors and neuroblastoma cell lines in which the CASR gene promoter P2 is not hypermethylated. PMID: 27862333
  31. Calcium exerted its effects on cartilaginous endplates matrix protein synthesis through activation of the extracellular calcium-sensing receptor. PMID: 27452962
  32. Polymorphic variations in VDR and CASR may be associated with survival after a diagnosis of colorectal neoplasms. PMID: 28765616
  33. CaSR and AP2S1 sequencing is worthwhile in patients with familial hyperparathyroidism and phenotype suggesting familial hypocalciuric hypercalcemia as it can diagnose up to 50% of cases. PMID: 28176280
  34. reduced expression of the CaSR is correlated with activation of the renin-angiotensin system, which induces increased vascular remodeling and vascular smooth muscle cell proliferation, and thereby associated with essential hypertension in the SHR rat model and in the Han Chinese population PMID: 27391973
  35. CaSR exerts a suppressive function in pancreatic tumorigenesis through a novel NCX1/Ca(2+)/beta-catenin signaling pathway. PMID: 27108064
  36. In whites, CaSR gene SNP rs1801725 was associated with serum calcium but not with risk of diabetes. PMID: 27510541
  37. Tumor CaSR expression is associated with an increased risk of lethal prostate cancer, particularly in tumors with low VDR expression. PMID: 27115058
  38. Functional interaction of upregulated CaSR and upregulated TRPC6 in pulmonary artery smooth muscle cells from idiopathic pulmonary arterial hypertension patients may play an important role in the development and progression of sustained pulmonary vasoconstriction and pulmonary vascular remodeling. PMID: 26968768
  39. This is a prospective observational study that measures the expression of vitamin D (VD) metabolising and signalling molecules and Ca(2+) sensing receptor (CaSR) in human Fallopian tube (FT) during the menstrual cycle and ectopic pregnancy (EP). PMID: 27770255
  40. CaSR expression was shown in HepG2 cells and human liver samples; CaSR may contribute to obesity-associated hepatic metabolic consequences PMID: 27565442
  41. Polymorphisms of CASR gene increase the risk of primary hyperparathyroidism. PMID: 26710757
  42. Calcium oxalate-induced renal injury is related to CaSR-mediated oxidative stress and increased mitogen-activated protein kinase signaling, which subsequently leads to CaOx crystal adhesion. PMID: 27965733
  43. The detection of CaSR gene mutations is suitable to differentiate states of hypercalcemia and may help to avoid invasive procedures such as parathyroidectomies. PMID: 27926951
  44. a novel loss-of-function mutation, G571W, in the CaSR gene in a Korean family with familial hypocalciuric hypercalcemia. PMID: 26386835
  45. There is a significant correlation between in vitro functional impairment of the CaSR at physiologic calcium concentrations and the severity of alterations in calcium homeostasis in patients. PMID: 27666534
  46. Calcium sensing receptor gene rs1801725 variants are not associated with susceptibility to colorectal cancer. PMID: 25124570
  47. physiological fetal hypercalcemia, acting on the CaSR, promotes human fetal lung development via cAMP-dependent opening of CFTR. PMID: 26911344
  48. CaSR and PTH1R signaling responses in cartilage and bone. [review] PMID: 26688334
  49. The calcium-sensing receptor may be involved in the modulation of inflammatory processes. [review] PMID: 26303192
  50. A986S polymorphism of CaSR is an independent predictor of PTH level in normocalcemic hyperparathyroidism patients, but not in asymptomatic hyperparathyroidism. PMID: 26332755
  51. Though this case has previously been published as a surgical case report, a full report of the medical management and underlying genetic etiology is warranted; this case underscores the importance of disclosing bi-parental heterozygosity for a gene causing severe neonatal disease particularly when treatment is available and illustrates the need for further in vitro studies of this CaSR mutation. PMID: 26855056
  52. Emerging roles of the CaSR in intestinal homeostasis and its therapeutic potential for gut pathology. [review] PMID: 26709005
  53. These findings demonstrate that CaSR-targeted compounds can rectify signaling disturbances caused by germline and somatic Galpha11 mutations, which respectively lead to calcium disorders and tumorigenesis; and that ADH2-causing Galpha11 mutations induce non-constitutive alterations in MAPK signaling. PMID: 26994139
  54. CaSR-induced constitutive macropinocytosis facilitates the sentinel function of macrophages, promoting the efficient delivery of ligands to cytosolic pattern-recognition receptors. PMID: 27050483
  55. Downregulation of CaSR may contribute to the prevention or suppression of tumor outgrowth in gastric cancer. PMID: 26153034
  56. The rs17251221 single nucleotide polymorphism of CaSR is a risk factor associated with breast cancer susceptibility, as well as a prognostic indicator. PMID: 24481145
  57. A novel naturally occurring deletion mutation within the CASR that apparently arose de novo in the father of the Autosomal dominant hypocalcemia proband. PMID: 26764418
  58. Aortic smooth muscle cells under static or strained conditions were exposed to CaSR agonists, R568, and CaSR silencing and over-expression. High Ca reduced CaSR expression. Cyclic strain or R568 prevented this. CaSR silencing enhanced calcification. PMID: 26436544
  59. the identification of a novel heterozygous loss-of-function mutation of the CASR gene in three siblings with familial hypocalciuric hypercalcaemia PMID: 26158657
  60. Results suggest that the G allele and the homozygous GG genotype of the CaSR rs17251221 polymorphism are protective against ovarian cancer and represent low risk for it. PMID: 26252839
  61. CaSR activation elevates visceral preadipocyte proliferation. PMID: 25986659
  62. these studies suggest that 14-3-3 binding at the carboxyl terminus provides an important buffering mechanism to increase the intracellular pool of CaSR available for signaling-evoked trafficking PMID: 26317416
  63. Both vitamin D and calcium are needed for protection against malignant transformation of the colon and that their effect is modulated by the presence of a functional CaSR. PMID: 25758239
  64. Considering the high allele frequency and significance level of the rs13068893C>G in the CASR gene, this SNP may have a key role in regulating the serum calcium level. PMID: 25972035
  65. Letter: overrepresentation of rare CASR coding variants in young French patients with idiopathic chronic pancreatitis. PMID: 26166472
  66. There is no association between CASR SNP rs1801725, although an association between altered calcium levels and gastrointestinal motility could not be ruled out. PMID: 26654249
  67. the S170T mutation induces a marked increase in CaSR sensitivity to [Ca(2+)]e and imply the allosteric regulation of the CaSR by aromatic amino acids PMID: 26431875
  68. Authors investigated whether common CASR gene variants are predictors for aortic and coronary artery calcification or influence risk factors such as serum calcium, phosphate and glucose concentrations in RTRs. PMID: 25786244
  69. the activation of CaSR in the collecting duct prevents the cyclic AMP-dependent increase in AQP2-phosphorylation at S256 and water permeability, counteracting the short-term vasopressin response. PMID: 25977473
  70. Rs1801725 (Ala986-Ser), rs1042636 (Arg990Gly) of CaSR gene and rs219778, rs219780 (Thr229Thr) of CLDN14 gene were significantly associated with kidney stone disease in patients from the Eastern part of India. PMID: 26107257
  71. We conclude that the simultaneous presence of the minor allele at rs1501899 and Arg990Gly may amplify the kidney stone risk in primary hyperparathyroidism patients. PMID: 24832896
  72. Novel activating mutation of CASR has been described in a 3-generation family with autosomal dominant hypocalcaemia. PMID: 25766501
  73. the severity of clinical neurological symptoms was inversely related to serum calcium levels and a high prevalence of renal calcifications and/or basal ganglia calcifications in children with Autosomal dominant hypocalcaemia PMID: 25039540
  74. These studies have revealed new insights into the CaSR signalling pathway and its role in regulating extracellular homeostasis and the etiology of parathyroid diseases--{REVIEW} PMID: 25910996
  75. Calcium-sensing receptor has a role in airway hyperresponsiveness and inflammation in allergic asthma PMID: 25904744
  76. Data show that the loss-of-function mutations, L173P and P221Q, but not the gain-of-function mutations, L173F and P221L, alter the cooperativity of the Ca(2+)-sensing receptor (CaSR). PMID: 25420019
  77. patients with vitamin D deficiency bearing the GG genotype of R990G SNP have higher plasma iPTH levels and lower serum calcium in comparison with the AG and AA genotype subjects PMID: 25695075
  78. No association was found between multiple kidney stones and polymorphisms of genes encoding KL, VDR, CASR. PMID: 26665756
  79. activated CaR affects intracellular pathways modulating NKCC2 activity rather than NKCC2 intracellular trafficking in renal cells, and throw further light on the pathological role played by active CaR mutants in Bartter syndrome type 5. PMID: 25631355
  80. evaluated CaSR mutations as a cause of disease in selected patients with idiopathic or familial parathyroid disorder; characterized novel 132 V mutation leading to familial hypercalciuric hypercalcemia PMID: 25091521
  81. This meta-analysis revealed that the G allele of CaSR R990G polymorphism increases susceptibility to urolithiasis and hypercalciuria. The A986S and Q1011E polymorphisms were associated with urolithiasis and hypercalciuria in specific populations. PMID: 25705702
  82. CaSR rs17251221 polymorphism is associated with susceptibility to hepatocellular carcinoma. PMID: 25270285
  83. CaSR is involved in the pulmonary vascular remodeling and pulmonary hypertension by promoting phenotypic modulation of small pulmonary arteries. PMID: 25063217
  84. results demonstrate a critical tumor suppressive role of CaSR in the colon. Restoration of CaSR expression and function is linked to regulation of the balance between proliferation, differentiation, and apoptosis PMID: 25701758
  85. The intron 4 polymorphism in CASR is a factor in diabetic nephropathy and diabetes mellitus. PMID: 25401741
  86. Data indicate that the total calcium-sensing receptor (CaSR) expression in circulating monocytes was significantly higher in rheumatoid arthritis (RA) patients with severe coronary artery calcification (CAC) than in patients with mild-to-moderate CAC. PMID: 25134967
  87. Neonatal severe primary hyperparathyroidism associated with biallelic Gly768Val mutations of the CASR in two siblings with severe hypercalcemia and hyperparathyroidism and their clinically and biochemically normal heterozygous parents was transmitted as an autosomal recessive disorder in this family PMID: 24854525
  88. CaSR-mediated increase in [Ca2+]i probably modulates cytoskeleton organization and gene expression via transcription factor CREB PMID: 25382680
  89. Exogenous Abetas stimulate the normal cortical adult astrocytes to produce and secrete VEGF-A through a CaSR-mediated mechanism. Abetas in the AD brain may make astrocytes into multi-agent AD-driving "machines" via a CaSR signaling mechanism(s). PMID: 24948534
  90. Case of a novel inactivating point mutation of CaSR gene that determines an atypical clinical presentation of FHH, characterized by hypercalcemia, hypercalciuria and inadequate normal PTH levels. PMID: 25292184
  91. The cholesterol-binding domains localize the CaSR dimers to lipid rafts. PMID: 25701780
  92. Authors summarize the role of CaSR in digestive physiology and pathophysiology, for example, the inactivation or mutation of the CaSR gene usually leads to one of several disorders of calcium metabolism. [Review] PMID: 25069966
  93. Calcium-sensing receptor gene (CaSR) might be a strong component of the complex genetic background regulating calcium excretion and stone formation in kidney PMID: 25019182
  94. under-expressed in gestational diabetes mellitus compared to healthy placentas PMID: 24930987
  95. The coexistence of primary hyperparathyroidism and familial hypocalciuric hypercalcaemia in some patients suggests a pathogenetic role of CaSR mutations in primary hyperparathyroidism. PMID: 21521328
  96. CaSR activation triggers Ca(2+)-dependent duodenal bicarbonate secretion PMID: 25331955
  97. findings provide new insights into the mechanisms by which Ca(2+) and amino acids regulate the CaSR and may pave the way for exploration of the structural properties of CaSR and other members of family C of the GPCR superfamily. PMID: 25305020
  98. Data suggest that activation of CASR in pancreatic beta cells has multiple effects including altering cadherin-based cell-cell adhesion, cell-to-cell communication, and expression/function of potassium and voltage-dependent calcium channels. [REVIEW] PMID: 24559921
  99. CaSR activation mediates Ca2+ influx and cell proliferation via TRPC3 and TRPC6 in human mesangial cells PMID: 24905090
  100. Despite comprehensive cardiometabolic phenotyping, no alterations in myocardial function, lipid distribution, or glucose metabolism were observed in familial hypocalciuric hypercalcemia. PMID: 24947037

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Involvement in disease Hypocalciuric hypercalcemia, familial 1 (HHC1); Hyperparathyroidism, neonatal severe (NSHPT); Hypocalcemia, autosomal dominant 1 (HYPOC1); Epilepsy, idiopathic generalized 8 (EIG8)
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 3 family
Tissue Specificity Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
Database Links

HGNC: 1514

OMIM: 145980

KEGG: hsa:846

STRING: 9606.ENSP00000420194

UniGene: Hs.435615

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