CDK16 Antibody

Code CSB-PA017648GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
Cdk16 antibody; CDK16_HUMAN antibody; Cell division protein kinase 16 antibody; Cyclin-dependent kinase 16 antibody; PCTAIRE antibody; PCTAIRE protein kinase 1 antibody; PCTAIRE-motif protein kinase 1 antibody; PCTAIRE1 antibody; PCTGAIRE antibody; PCTK1 antibody; Serine/threonine-protein kinase PCTAIRE-1 antibody
Raised in
Species Reactivity
Human PCTK1
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).
Gene References into Functions
  1. CDK16 negatively modulates p53 signaling pathway to promote radioresistance in lung cancer cells. PMID: 29344296
  2. CDK16 is significantly up-regulated in non-small cell lung cancer tumor tissue and plays a role in promoting cell proliferation. PMID: 29674275
  3. Authors provided the first evidence that CDK16 is an bona fide oncogene in HCC, and multiple activating mechanisms at transcriptional and posttranscriptional levels together contributes to CDK16 up-regulation in HCC. PMID: 28716136
  4. CDK-16 upregulation in serous EOC cells may represent a negative feedback loop to promote ovarian cell differentiation in malignantly-transformed serous epithelial ovarian cancer cells PMID: 26546806
  5. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC PMID: 25809707
  6. Activation of PCTAIRE-1 is mediated through interaction with the phosphorylated form of cyclin Y in complex with 14-3-3. PMID: 26205494
  7. An unexpected role for PCTAIRE1 in regulating p27 stability, mitosis, and tumor growth. PMID: 25205104
  8. Dysfunction of MKL2 and its transcriptional coactivation partner, serum response factor (SRF), was supported by a decrease in gene and protein expression of PCTAIRE1, a downstream target of MKL2:SRF heterodimer transcriptional activation PMID: 23692340
  9. Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis PMID: 24931367
  10. a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs. PMID: 22798068
  11. CCNY binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site. PMID: 22184064
  12. Cdk5-dependent phosphorylation of Pctaire1 at Ser95 plays an important role in dendrite development PMID: 21335063
  13. Data show that various forms of PCTAIRE-1 transfected into neuroblastoma cell lines could either promote or inhibit neurite outgrowth, suggesting a potential role for the PCTAIRE-1 gene product in the control of neurite outgrowth. PMID: 12154078

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Subcellular Location
Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Tissue Specificity
Detected in pancreas islets (at protein level). Detected in brain and pancreas.
Database Links

HGNC: 8749

OMIM: 311550

KEGG: hsa:5127

STRING: 9606.ENSP00000276052

UniGene: Hs.496068

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