CDK16 Antibody

1. CDK16 negatively modulates p53 signaling pathway to promote radioresistance in lung cancer cells. PMID: 29344296
2. CDK16 is significantly up-regulated in non-small cell lung cancer tumor tissue and plays a role in promoting cell proliferation. PMID: 29674275
3. Authors provided the first evidence that CDK16 is an bona fide oncogene in HCC, and multiple activating mechanisms at transcriptional and posttranscriptional levels together contributes to CDK16 up-regulation in HCC. PMID: 28716136
4. CDK-16 upregulation in serous EOC cells may represent a negative feedback loop to promote ovarian cell differentiation in malignantly-transformed serous epithelial ovarian cancer cells PMID: 26546806
5. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC PMID: 25809707
6. Activation of PCTAIRE-1 is mediated through interaction with the phosphorylated form of cyclin Y in complex with 14-3-3. PMID: 26205494
7. An unexpected role for PCTAIRE1 in regulating p27 stability, mitosis, and tumor growth. PMID: 25205104
8. Dysfunction of MKL2 and its transcriptional coactivation partner, serum response factor (SRF), was supported by a decrease in gene and protein expression of PCTAIRE1, a downstream target of MKL2:SRF heterodimer transcriptional activation PMID: 23692340
9. Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis PMID: 24931367
10. a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs. PMID: 22798068
11. CCNY binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site. PMID: 22184064
12. Cdk5-dependent phosphorylation of Pctaire1 at Ser95 plays an important role in dendrite development PMID: 21335063
13. Data show that various forms of PCTAIRE-1 transfected into neuroblastoma cell lines could either promote or inhibit neurite outgrowth, suggesting a potential role for the PCTAIRE-1 gene product in the control of neurite outgrowth. PMID: 12154078

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HGNC: 8749

OMIM: 311550

KEGG: hsa:5127

STRING: 9606.ENSP00000276052

UniGene: Hs.496068