CDK16 Antibody

Datasheet

Code	CSB-PA017648ESR2HU
Size	US$166
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Image	Western blot All lanes: CDK16 antibody at 5μg/ml Lane 1: Mouse brain tissue Lane 2: Mouse small intestine tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 56, 64, 57 kDa Observed band size: 56 kDa Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA017648ESR2HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CDK16 Polyclonal antibody

Uniprot No.

Q00536

Target Names

CDK16

Alternative Names

Cdk16 antibody; CDK16_HUMAN antibody; Cell division protein kinase 16 antibody; Cyclin-dependent kinase 16 antibody; PCTAIRE antibody; PCTAIRE protein kinase 1 antibody; PCTAIRE-motif protein kinase 1 antibody; PCTAIRE1 antibody; PCTGAIRE antibody; PCTK1 antibody; Serine/threonine-protein kinase PCTAIRE-1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Cyclin-dependent kinase 16 protein (277-496AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).

Gene References into Functions

CDK16 negatively modulates p53 signaling pathway to promote radioresistance in lung cancer cells. PMID: 29344296
CDK16 is significantly up-regulated in non-small cell lung cancer tumor tissue and plays a role in promoting cell proliferation. PMID: 29674275
Authors provided the first evidence that CDK16 is an bona fide oncogene in HCC, and multiple activating mechanisms at transcriptional and posttranscriptional levels together contributes to CDK16 up-regulation in HCC. PMID: 28716136
CDK-16 upregulation in serous EOC cells may represent a negative feedback loop to promote ovarian cell differentiation in malignantly-transformed serous epithelial ovarian cancer cells PMID: 26546806
GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC PMID: 25809707
Activation of PCTAIRE-1 is mediated through interaction with the phosphorylated form of cyclin Y in complex with 14-3-3. PMID: 26205494
An unexpected role for PCTAIRE1 in regulating p27 stability, mitosis, and tumor growth. PMID: 25205104
Dysfunction of MKL2 and its transcriptional coactivation partner, serum response factor (SRF), was supported by a decrease in gene and protein expression of PCTAIRE1, a downstream target of MKL2:SRF heterodimer transcriptional activation PMID: 23692340
Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis PMID: 24931367
a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs. PMID: 22798068
CCNY binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site. PMID: 22184064
Cdk5-dependent phosphorylation of Pctaire1 at Ser95 plays an important role in dendrite development PMID: 21335063
Data show that various forms of PCTAIRE-1 transfected into neuroblastoma cell lines could either promote or inhibit neurite outgrowth, suggesting a potential role for the PCTAIRE-1 gene product in the control of neurite outgrowth. PMID: 12154078

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Subcellular Location

Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily

Tissue Specificity

Detected in pancreas islets (at protein level). Detected in brain and pancreas.

Database Links

HGNC: 8749

OMIM: 311550

KEGG: hsa:5127

STRING: 9606.ENSP00000276052

UniGene: Hs.496068

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Protein Phosphorylation: The Dynamic Language of Cellular Regulation Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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