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| Code | CSB-PA005431LA01HU |
| Size | US$299 |
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| Full Product Name | Rabbit anti-Homo sapiens (Human) CIDEA Polyclonal antibody | ||||||||
| Uniprot No. | O60543 | ||||||||
| Target Names | CIDEA | ||||||||
| Alternative Names | CIDEACell death activator CIDE-A antibody; Cell death-inducing DFFA-like effector A antibody | ||||||||
| Raised in | Rabbit | ||||||||
| Species Reactivity | Human, Mouse | ||||||||
| Immunogen | Recombinant Human Cell death activator CIDE-A protein (1-51AA) | ||||||||
| Immunogen Species | Homo sapiens (Human) | ||||||||
| Conjugate | Non-conjugated The CIDEA Antibody (Product code: CSB-PA005431LA01HU) is Non-conjugated. For CIDEA Antibody with conjugates, please check the following table. |
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| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Purification Method | >95%, Protein G purified | ||||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||||
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
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| Form | Liquid | ||||||||
| Tested Applications | ELISA, WB, IHC, IF | ||||||||
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| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
Applications : Western blot
Sample type: cells
Review: western blot analysis of the expression levels of CIDEA and METTL16 in HepG2 cells.
By Anonymous
| Function |
Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
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| Gene References into Functions |
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| Involvement in disease | In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle. |
| Subcellular Location | Lipid droplet. Nucleus. |
| Tissue Specificity | Expressed in omental and subcutaneous adipose tissue (at protein level). |
| Database Links |
HGNC: 1976 OMIM: 604440 KEGG: hsa:1149 STRING: 9606.ENSP00000320209 UniGene: Hs.249129 |
