Recombinant Human Cell death activator CIDE-A (CIDEA)

1. Cidea, unexpectedly, functions molecularly as an indirect inhibitor of thermogenesis via inhibition of UCP1 activity. PMID: 27923808
2. These data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative. PMID: 26118629
3. Since Cide-A protein plays a role in the development of metabolic diseases such as obesity, metabolic syndrome, type 2 diabetes and their vascular complications, CIDE -A gene and protein are potential therapeutic targets for these diseases. PMID: 24413203
4. The lowest mean relative of the gene expression for CIDE-A was observed in the group of obese patients with aortic aneurysm and lipid disorders PMID: 25720106
5. the association of tag-single nucleotide polymorphisms and haplotype structures of the CIDEA gene with obesity in a Han Chinese population, was investigated. PMID: 24057179
6. CIDE proteins expression correlate with tumor and survival characteristics in patients with renal cell carcinoma. PMID: 23475172
7. Insulin regulates CIDEA and CIDEC expression via PI3K, and it regulates expression of each protein via Akt1/2-and JNK2-dependent pathways, respectively, in human adipocytes. PMID: 21636835
8. The proportion of subjects with CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population was significantly higher based on genotype, in the order: GG PMID: 21106268
9. CIDEA binds to liver X receptors and regulates their activity in vitro. PMID: 21315073
10. These data indicate that the carboxy-terminal domain of Cidea directs lipid droplet targeting, lipid droplet clustering, and triglyceride accumulation, whereas the amino terminal domain is required for Cidea-mediated development of enlarged lipid droplets PMID: 20810722
11. CIDEC is essential for the differentiation of adipose tissue PMID: 20945533
12. These results suggest that CIDEA and CIDEC are novel genes regulated by insulin in human adipocytes and may play key roles in the effects of insulin, such as anti-apoptosis and lipid droplet formation. PMID: 20154362
13. Methylation status of CIDEA, HAAO and RXFP3 had significant association with microsatellite instability in endometrial tumors. PMID: 20211485
14. We propose an important and human-specific role for CIDEA in lipolysis regulation and metabolic complications of obesity. PMID: 15919794
15. results support a role for cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) alleles in human obesity PMID: 16186410
16. deglycosylation of CIDE-A correlated with enhanced nuclear export of the protein, and that high level of nonglycosylated CIDE-A inhibited TGFbeta1-dependent cell death. PMID: 17080483
17. No dysregulation of CIDEA expression was observed in individuals with the metabolic syndrome PMID: 17895319
18. The expression of the CIDE-A gene was regulated by CpG methylation of the promoter region. PMID: 18033804
19. F allele of the CIDEA gene may serve as a risk factor for phenotypes related to metabolic syndrome in Japanese men. PMID: 18328351
20. Cidea and other lipid droplet proteins define a novel, highly regulated pathway of triglyceride deposition in human WAT. PMID: 18509062
21. CIDEa is sequestered in mitochondria while transfer of this potentially dangerous protein from mitochondria into nucleus intensifies or even initiates apoptosis. PMID: 18645223
22. CIDEA is involved in adipose tissue loss in cancer cachexia and this may, at least in part, be due to its ability to inactivate PDC, thereby switching substrate oxidation in human fat cells from glucose to FAs. PMID: 19010897

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HGNC: 1976

OMIM: 604440

KEGG: hsa:1149

STRING: 9606.ENSP00000320209

UniGene: Hs.249129