MCM5 Antibody

Code CSB-PA699652
Size US$297
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  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MMP-11 antibody.
  • Immunofluorescence analysis of A549 cells, using MMP-11 antibody.
  • Western blot analysis of extracts from A549 cells, using MMP-11 antibody.
  • Western blot analysis of extracts from HepG2 cells (Lane 2) and HeLa cells (Lane 3), using MMP-11 antiobdy. The lane on the left is treated with systhesized peptide.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MCM5 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
CDC 46 antibody; CDC46 antibody; CDC46 homolog antibody; Cell division cycle 46 antibody; DNA replication licensing factor antibody; DNA replication licensing factor MCM 5 antibody; DNA replication licensing factor MCM5 antibody; MCM 5 antibody; MCM5 antibody; MCM5_HUMAN antibody; MGC5315 antibody; Minichromosome maintenance complex component 5 antibody; Minichromosome maintenance deficient (S. cerevisiae) 5 antibody; Minichromosome maintenance deficient 5 antibody; Minichromosome maintenance deficient protein 5 antibody; P1 CDC46 antibody; P1-CDC46 antibody
Raised in
Species Reactivity
Synthesized peptide derived from Human MMP-11 antibody.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
IF 1:100-1:500
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Gene References into Functions
  1. Minichromosome maintenance 5 was shown as an independent prognostic biomarker for patients with cervical cancer PMID: 29642758
  2. MCM5 expression is associated with the malignant status and poor prognosis in cervical adenocarcinoma patients. PMID: 29253764
  3. The RAS-related nuclear protein ((P) ran), breast cancer metastasis suppressor 1 ((P) brms1) and minichromosome maintenance complex component 5 ((P) mcm5) promoters have the specificity and strength needed for cancer-specific expression-targeted gene therapy. PMID: 27140445
  4. the incorporation of physiological levels of MCM5 into HIV-1 virions facilitates viral cDNA accumulation in newly infected cells, probably by modifying nucleic acid configuration during reverse transcription. PMID: 27414250
  5. MCM5 is a novel gene involved in Meier-Gorlin syndrome. PMID: 28198391
  6. Our findings support the hypothesis that MCM5 targeting may be regarded as an effective molecular therapy against anaplastic thyroid carcinoma PMID: 26911376
  7. we could consider miRNA-10b and MCM5 mRNA as prognostic markers and potential therapeutic targets in breast cancer to be applied to other patient data sets. PMID: 25596707
  8. The increased expression of MCM5 protein begins at the oral pre-cancerous stage and is significantly associated with the aggressive progression and poor prognosis of OSCC. PMID: 24245508
  9. Data indicate that MCM-BP binds USP7 on chromatin and can mediate an interaction between the USP7 and MCM proteins. PMID: 24190967
  10. The results of this study demonistrated that Mcm5 shows a highly significant correlation with Alcohol use disorders-induced decreases in the volume of the left parietal supramarginal gyrus and neuropsychological measures. PMID: 23095216
  11. MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival. PMID: 21233845
  12. lack of MCM5 proteins expression which may explain commonly known low mitotic activity of desmoid tumour cells PMID: 21478101
  13. MCM-5 expression was significantly associated with tumor size, presence of lymph node metastases and tumor histopathological stage. Patients with high MCM-5 expression had significantly shorter survival times. PMID: 20694513
  14. Could use the urinary hTERT, SENP1, PPP1CA, and MCM5 mRNA to detect bladder cancer recurrence. PMID: 21106093
  15. Results further confirm the importance of MCM5 in malignant transformation and in the pathogenesis of cervical dysplasia. PMID: 15696126
  16. The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation. PMID: 16199513
  17. MCM5 is part of the GINS complex. PMID: 17557111
  18. results demonstrate pattern and frequency of MCM5 expression in various skin diseases PMID: 17988337
  19. Immunofluorescence technology to quantify cervical cell expression of two biomarkers p16(INK4A) and Mcm5 was developed and evaluated by both microscopy and flow cytometry. PMID: 18181189
  20. No significant association was observed between MCM-5 protein expression and the clinicopathological characteristics of colon cancer examined. PMID: 18465232
  21. Cyclin E is shown to directly interact with and colocalize on centrosomes with the DNA replication factor MCM5 in a centrosomal localization sequence-dependent but Cdk2-independent manner. PMID: 18799789
  22. Analysis of MCM5 expression in aggressive fibromatosis (desmoid tumor) is reported. PMID: 19130399

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Involvement in disease
Meier-Gorlin syndrome 8 (MGORS8)
Subcellular Location
Nucleus. Chromosome. Cytoplasm, cytosol.
Protein Families
MCM family
Database Links

HGNC: 6948

OMIM: 602696

KEGG: hsa:4174

STRING: 9606.ENSP00000216122

UniGene: Hs.517582

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