NOX4 Antibody

Datasheet
Code CSB-PA015961LA01HU
See More Details Free Antibody trial simple
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA015961LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA015961LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) NOX4 Polyclonal antibody
Uniprot No. Q9NPH5
Target Names NOX4
Alternative Names NADPH oxidase 4 (EC 1.6.3.-) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Renal NAD(P)H-oxidase), NOX4, RENOX
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human NADPH oxidase 4 protein (210-424AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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Citations

Wound Healing Promoting Activity of Tonsil-Derived Stem Cells on 5-Fluorouracil-Induced Oral Mucositis Model. Jung H, et al,Tissue Engineering and Regenerative Medicine,2019

Sample type: Syrian golden hamsters tissue section
Sample species: Mouse
Antibody dilution factor: 1:500
Application: IHC
Review: Immuno- histochemistry for TGF-b and NOX4 on days 10 and 14. On day 10, the TMSC group showed the highest TGF-b and NOX4 expression. *p<0.05, **p<0.01. 9 200.

Target Data

Function Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.; FUNCTION
Subcellular Location Endoplasmic reticulum membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein, Cell junction, focal adhesion
Tissue Specificity Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain t
Database Links

HGNC: 7891

OMIM: 605261

KEGG: hsa:50507

STRING: 9606.ENSP00000263317

UniGene: Hs.371036

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