PRDX2 Antibody

Code CSB-PA339235LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
  • Western blot
    All lanes: PRDX2 antibody at 9μg/ml
    Lane 1: Mouse liver tissue
    Lane 2: Mouse spleen tissue
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 22, 16 kDa
    Observed band size: 22 kDa

  • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA339235LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA339235LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA339235LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PRDX2 Polyclonal antibody
Uniprot No. P32119
Target Names PRDX2
Alternative Names Epididymis secretory sperm binding protein Li 2a antibody; HEL S 2a antibody; MGC4104 antibody; Natural killer cell enhancing factor B antibody; Natural killer cell-enhancing factor B antibody; Natural Killer Enhancing Factor B antibody; NKEF B antibody; NKEF-B antibody; NKEFB antibody; Peroxiredoxin 2 antibody; Peroxiredoxin-2 antibody; PRDX 2 antibody; PRDX2 antibody; PRDX2_HUMAN antibody; PrP antibody; PRX2 antibody; PRXII antibody; PTX1 antibody; TDPX1 antibody; Thiol Specific Antioxidant 1 antibody; Thiol specific antioxidant protein antibody; Thiol-specific antioxidant protein antibody; Thioredoxin Dependent Peroxide Reductase 1 antibody; Thioredoxin peroxidase 1 antibody; Thioredoxin-dependent peroxide reductase 1 antibody; Torin antibody; TPX1 antibody; TSA antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Peroxiredoxin-2 protein (2-65AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
Gene References into Functions
  1. Changes in PRDX2 redox/oligomeric states correlated with Obstructive Sleep Apnea severity/metabolic status. Six month of positive airway pressure (PAP) treatment decreased this overoxidation and generated multimeric overoxidized forms associated with chaperone/transduction signaling activity of PRDX2. PMID: 27864139
  2. our data suggest that overexpression of peroxiredoxin-2, annexin A2, and heat shock protein beta-1 was correlated with tumor invasion, metastasis, and poor prognosis, and therefore, these proteins may serve as potential diagnostic and therapeutic biomarkers. PMID: 29332450
  3. PRX-2 gene can inhibit the phenotypic change of Epidermal Stem Cells differentiating into Sweat Gland Cells and improve the ability to maintain their own specific antigens. PMID: 30070795
  4. Prx II exhibited more effective molecular chaperone activity than Prx I when UCH-L1 was the client. Prx II interacted with UCH-L1 through its C-terminal region to protect UCH-L1 from thermal or oxidative inactivation PMID: 29339092
  5. The c-Myc/miR-200b/PRDX2 loop regulates colorectal cancer (CRC) progression and its disruption enhances tumor metastasis and chemotherapeutic resistance in CRC. PMID: 29258530
  6. Lys191 residue in this exposed C-terminal region of oxidized Prx2 is polyubiquitinated and the ubiquitinated Prx2 is readily degraded in proteasome and autophagy. PMID: 27703196
  7. Our findings indicate that Prdx2 might have an important role in the regulation of trophoblast proliferation and apoptosis during early pregnancy, and that its expression is mediated by c-Myc. Thus, these two proteins may be involved in the pathogenesis of RM and may represent potential therapeutic targets PMID: 28661480
  8. Data indicate that Prx2 is denitrosylated by Srxn1-mediated, and the two proteins physically bind via disulfide bond formation, providing a structural basis for the enzymatic reaction that requires ATP hydrolysis. PMID: 27821734
  9. Overexpression of peroxiredoxin 2 and VEGFR2 in pterygium might be involved in the pathogenesis or recurrence of pterygium. The increase of VEGFR2 might be related to the increase of peroxiredoxin 2 in response to excessive reactive oxygen species from ultraviolet exposure. PMID: 28489720
  10. Knockdown of peroxiredoxin 2 (Prdx2) reduced the self-renewal and sphere formation in colon cancer stem cells (CSCs). PMID: 27894099
  11. PRDX2 and p-AKT protein expression were analyzed by immunohistochemistry technology. PMID: 28432271
  12. Association and oligomerization of Prx II could take part in recovery and protection of the CK BB enzyme activity from inactivation during heat-induced stress. PMID: 29227081
  13. Prx II plays a key role in the cancer stem cell self-renewal of hepatocellular carcinoma cells through redox regulation. PMID: 26866938
  14. Peroxiredoxin-2 (PRDX2) and hemoglobin-subunits proteins, which are closely involved in the response to oxidative stress. PMID: 27869326
  15. High PRDX2 expression is associated with colorectal cancer progression. PMID: 28125800
  16. Knockdown of forkhead Box M1 (FoxM1) reduced Prx II levels in H-ras(G12V)-hepatocellular carcinoma (HCC) cells, indicating FoxM1 as a direct transcription factor of Prx II in HCC. PMID: 26500057
  17. Prx1 and Prx2 are likely targets of urate hydroperoxide in cells. Oxidation of Prxs by urate hydroperoxide might affect cell function and be partially responsible for the pro-oxidant and pro-inflammatory effects of uric acid. PMID: 28348082
  18. Data indicate that peroxiredoxin 2 (PRDX2) was upregulated in white matter multiple sclerosis (MS) lesions mainly in astrocytes, and its expression level was positively correlated with the degree of inflammation and oxidative stress, and suggest that PRDX2 expression contributes to the resistance of astrocytes against oxidative damage. PMID: 28375164
  19. The levels of expression of carbonic anhydrase 2, catalase, and PRDX2 in the nipple discharge were significantly increased in breast ductal carcinoma patients as compared to controls. PMID: 26970563
  20. Activation of PRX1 and -2 indicate cold atmospheric plasma affects redox homeostasis in osteosarcoma cells PMID: 28314261
  21. ig-h3, Peroxiredoxin-2, and NRF2 have roles in cervical carcinogenesis PMID: 28261610
  22. Data show that peroxiredoxins PRDX1 and PRDX2 are upregulated in tumor B cells as compared with normal counterparts. PMID: 26636537
  23. Data show the protein partners of human Prx1 and Prx2 and identified three sequence motifs, or combination thereof in Prxs partners, namely: CXXC, PXXP, and LXXLL. that can be important for protein localization, function and biological pathways. [review] PMID: 26548861
  24. Oxidative stress promotes PRX2 and PRX3 hyperoxidation and attenuates pro-survival signaling in aging chondrocytes. PMID: 26797130
  25. Prx2 glutathionylation is a favorable reaction that can occur in cells under oxidative stress and may have a role in redox signaling. GSH/Grx1 provide an alternative mechanism to thioredoxin and thioredoxin reductase for Prx2 recycling. PMID: 26601956
  26. the species with one disulfide and one hyperoxidized active site was decameric for Prx2 and dimeric for Prx3. Reduction and re-oxidation of the hyperoxidized dimer of Prx3 produced hyperoxidized monomers PMID: 26614766
  27. Functional roles of catalase, PRDX2 and GPX1 during oxidative stress in human erythrocytes. PMID: 25786472
  28. Further conclusion showed that Prdx2 regulates VM formation by targeting VEGFR2 activation, which now represents as a therapeutic target for RC. PMID: 25471788
  29. Prx II has an important role in cancer cell survival via the modulation of signaling molecules involved in apoptosis and the phosphorylation of JNK by the downregulation of reactive oxygen species levels in A549/GR cells. PMID: 26021759
  30. Reported increased expression of ALDH3A1, PDIA3, and PRDX2 in pterygia using a proteomic approach. These proteins are presumed to have a protective role against oxidative stress-induced apoptosis. PMID: 25221425
  31. Prx-2 activity is compromised during red blood cell storage. PMID: 25264713
  32. two placental proteins, Prx3 and Prx4, may act as new placental immune targets. PMID: 25323516
  33. the main role of Prx2 in human erythrocytes is not to eliminate peroxide substrates. PMID: 24952139
  34. Our work is the first to show that nuclear levels of PRDX2 display circadian oscillation participating in the regulation of human keratinocytes redox balance. PMID: 24814289
  35. Taken together, cloned porcine kidney is more susceptible in JNK-induced apoptosis caused by PrxII phosphorylation, in oxidative stress condition PMID: 24909612
  36. the reduced expression of iNOS or peroxiredoxin 2 may play an important role in the carcinogenesis of gastric cancer PMID: 24750185
  37. Results suggest that PRDX2 may perform an important function in the pathogeneis of RCMD. PMID: 24862795
  38. findings suggest a model in which the release of PRDX2 and TRX from macrophages can modify the redox status of cell surface receptors and enable induction of inflammatory responses PMID: 25097261
  39. In this work we characterize Prx2 tyrosine nitration, a post-translational modification on a noncatalytic residue that increases its peroxidase activity and its resistance to overoxidation. PMID: 24719319
  40. Prdx2 has an essential role in regulating oxidation-induced apoptosis in colorectal cancer cells. PMID: 24234423
  41. Impaired antioxidant activity of Prx2 could contribute to the hemolysis. PMID: 24636884
  42. These findings suggest that the transduced PEP-1-PRX2 has neuroprotective functions against oxidative stress-induced cell death in vitro and in vivo PMID: 24631653
  43. It documents that the antioxidant protein peroxiredoxin-2 (PRDX2), the third most abundant cytoplasmic protein in RBCs, interacts with the cytoplasmic domain of B3. PMID: 23123411
  44. Proteomic data suggest a limited protein set is involved in SET- (template activating factor-I-) mediated cytotoxicity of TCE (trichloroethylene) in hepatocytes; this set includes CFL1 (cofilin 1), PRDX2 (peroxiredoxin 2), and S100-A11 (calgizzarin). PMID: 24631019
  45. cellular distribution of Peroxiredoxin I and II in human eyes PMID: 24152995
  46. Up-regulation of peroxiredoxin-2 is associated with gemcitabine resistance in pancreatic cancer. PMID: 24222118
  47. Data show peroxiredoxin 2 (Prx2) oxidation was detected at erythrocyte:neutrophil ratios found in blood and reversed over time as the oxidative burst subsided. PMID: 23603832
  48. Data indicate that engineered Prx2 and Prx3 variants C-terminal residues modulate the extent of hyperoxidation. PMID: 24003226
  49. our findings reveal that Prx2 is a key regulator of invasion and metastasis in melanoma PMID: 23749642
  50. Hyperoxidized peroxiredoxin 2 interacts with the protein disulfide- isomerase ERp46. PMID: 23713588
  51. Our data showed that the elevated AZGP1 and decreased PEDF and PRDX2 expressions in CRC serum and tissues were correlated with liver metastases. PMID: 23393224
  52. Real-time PCR, western blot and immunohistochemistry showed that peroxiredoxin 2 was increased in pterygium compared to healthy conjunctiva. PMID: 23499777
  53. PRX2 battles poly(ADP-ribose) polymerase 1- and p53-dependent prodeath pathways after ischemic injury PMID: 23429506
  54. our results strongly suggest that PRDX2 is a targetable 'metabolic adaptor' driver protein implicated in the selective growth of metastatic cells in the lungs by protecting them against oxidative stress. PMID: 22430214
  55. Drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the importance of redox-dependent mechanisms into development of cisplatin resistance. PMID: 23113308
  56. Two cytosolic peroxiredoxins (Prdx1 and Prdx2) have distinct roles in the cellular peroxide signaling and compete for available peroxide substrate. PMID: 22902630
  57. These findings suggest that Prx II plays an important role in preventing hemolytic anemia from oxidative stress by binding to Hb as a decameric structure to stabilize it. PMID: 22960070
  58. Results show that peroxiredoxin 2 (Prx2) could prevent DNA from undergoing oxidative stress. PMID: 22805285
  59. Plasma peroxiredoxins 1 and 2, and tropomyosin 4 were shown to associate with asbestos-exposure, and peroxiredoxin 1 with lung cancer. PMID: 22537621
  60. PDX2 was involved in malignant transformation of human bronchial epithelial cell induced by crystalline nickel sulfide. PMID: 16188094
  61. Data suggest that peroxiredoxin 2 may be involved in the persistence of pro-inflammatory cells in chronic inflammation. PMID: 22565169
  62. Data suggest that SNPs of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer. PMID: 22215146
  63. Study identified peroxiredoxin 2 (PRDX2) as a novel potential tumor suppressor gene in acute myeloid leukemia (AML). PMID: 22207736
  64. In beta-thalassemic erythroid cells the reduction of delta-aminolevulinate synthase-2 activity and the increased expression of peroxiredoxin-2 might represent two novel stress-response protective systems. PMID: 21750082
  65. a physiological function of PrxII as the residential antioxidant safeguard specific to the redox-sensitive VEGFR2 PMID: 22099303
  66. Prx2 expression in nucleus and cytoplasm distinctively regulates androgen receptor signaling, is involved in prostate cancer growth, and may promote castration resistance in prostate cancer. PMID: 21539911
  67. PRDX2 was up-regulated in women older than 38 years, and its expression in cumulus cells was associated with embryo quality PMID: 20721618
  68. PrxII is likely to be attributed to a tumor survival factor positively regulating JNK-dependent DNA repair with its inhibition possibly sensitizing cancer cells to chemotherapeutic agents. PMID: 21148313
  69. These results establish PRDX 2 as a candidate for chemotherapy responsiveness marker in osteosarcoma. PMID: 21137073
  70. High PRDX2 expression in the cytoplasm is associated with uterine cervix carcinogenesis. PMID: 21119665
  71. proteomic profiling used to identify the target proteins of miR-122a in hepatocellular carcinoma; PRDXII was identified to be the new target of miR-122a PMID: 20859956
  72. Data suggest that anti-Prx2 autoantibodies would be a useful marker for systemic vasculitis and would be involved in the inflammatory processes of systemic vasculitis. PMID: 20646000
  73. Addition of an uncharged derivative of leucine hydroperoxide to intact erythrocytes caused Prx2 oxidation with no concomitant loss in glutathione. PMID: 20840079
  74. Silencing of PRDX2 caused decreased rates of Hep3B cell growth and clone formation, increased rates of cell apoptosis, and increased the levels of endogenous ROS and MDA. PMID: 18578994
  75. PrxII might play an important role in hepatocarcinogenesis and might be used as a molecular target for HCC prevention and treatment. PMID: 17524271
  76. could act as an autoantigen of a streptococcal-induced autoimmune response and represents a target of the exaggerated T cell response in psoriasis. PMID: 20363977
  77. Exposure to Chloramines and hypochlorous acid inflammatory oxidants will result in Prx2 oxidation and could compromise the erythrocyte's ability to resist damaging oxidative insult. PMID: 19716412
  78. Protein levels of Prx-I and Prx-II were significantly increased in Alzheimer Disease and Down Syndrome. PMID: 11771746
  79. Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site PMID: 11904290
  80. 2-Cys Prxs act in a mutually nonredundant and sometimes stress-specific fashion to protect human cells from oxidant injury. The substantial resistance of human cells to hydroperoxides may result in part from the additive action of multiple Prxs PMID: 12080185
  81. Peroxiredoxin 2 levels are significantly increased in the frontal cortex of patients with Down syndrome, Alzheimer and Pick's disease and provides evidence for existence of compensatory response in increased cell loss. PMID: 12650976
  82. decreased expression of PRDX2 may contribute to the altered redox state in Down syndrome at levels comparable to that of the increased expression of SOD1 PMID: 12943237
  83. Prx II can be used as a novel marker of vascular tumors and preferential expression of Prx II is found in benign vascular tumors. PMID: 12963914
  84. results show that sestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of peroxiredoxins containing Cys-SO(2)H PMID: 15105503
  85. Prx I and Prx II are induced at the early and late stage of differentiation of normal human epidermal keratinocytes. PMID: 15864612
  86. loss of IDPc and Prx-II during tumor development may involve in tumor progression and metastasis PMID: 15936593
  87. in the erythrocyte Prx2 is extremely efficient at scavenging H(2)O(2) noncatalytically PMID: 17105810
  88. We propose a model in which Prxs function as peroxide dosimeters in subcellular processes that involve redox cycling, with hyperoxidation controlling structural transitions that alert cells of perturbations in peroxide homeostasis. PMID: 17145963
  89. peroxiredoxin 2 has a tertiary structure that facilitates reaction of the active site thiol with hydrogen peroxide while restricting its reactivity with other thiol reagents PMID: 17329258
  90. Human Prdx1 and Prdx2 possess unique functions and regulatory mechanisms and that Cys(83) bestows a distinctive identity to Prdx1. PMID: 17519234
  91. observation of increased SNO-Prx2 in human Parkinson's disease (PD) brains, and S-nitrosylation of Prx2 inhibited both its enzymatic activity and protective function from oxidative stress PMID: 18003920
  92. Peroxiredoxin II (PRXII) exclusively expressed in bronchiolitis obliterans syndrome. PMID: 18022079
  93. Significantly decreased expression of Prx-2, -3, and -5 in FED may suggest an alteration in the ability of endothelial cells to withstand oxidant-induced damage and may be closely related to the pathogenesis of this disease. PMID: 18378575
  94. study reports identification of Prx2 in the erythrocyte membrane from hereditary spherocytosis patients; presence of Prx2 in erythrocyte membranes was linked to higher levels of oxidative stress, as reflected by increased membrane bound hemoglobin PMID: 18387321
  95. 2-cysteine peroxiredoxins from Homo sapiens, Arabidopsis thaliana, and Pisum sativum as well as a carboxy-terminally truncated variant were subjected to isothermal titration calorimetry analysis. PMID: 18553980
  96. analysis of a protein thiosulfinate intermediate in the reduction of cysteine sulfinic acid in peroxiredoxin by human sulfiredoxin PMID: 18593714
  97. The results suggest that Prx II oxidation does not relate to the pathogenesis of IPF/UIP PMID: 18606608
  98. peroxiredoxin (Prx) I and Prx II are specific targets of HDAC6 PMID: 18606987
  99. inhibiting peroxiredoxin II sensitizes glioma cells to oxidative stress PMID: 18718523
  100. Prx2 is a key antioxidant enzyme for the erythrocyte and reveal red blood cells as active oxidant scrubbers in the bloodstream. PMID: 19061854

Show More

Hide All

Subcellular Location Cytoplasm
Protein Families Peroxiredoxin family, AhpC/Prx1 subfamily
Database Links

HGNC: 9353

OMIM: 600538

KEGG: hsa:7001

STRING: 9606.ENSP00000301522

UniGene: Hs.432121

Most popular with customers


Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

© 2007-2020 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1