PTPRR Antibody

Code CSB-PA624019LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA624019LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA624019LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PTPRR Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Ch-1PTPase antibody; Ch1 PTPase antibody; DKFZp781C1038 antibody; EC PTP antibody; ECPTP antibody; FLJ34328 antibody; MGC131968 antibody; MGC148170 antibody; NC PTPCOM1 antibody; NC-PTPCOM1 antibody; Protein tyrosine phosphatase Cr1PTPase precursor antibody; Protein tyrosine phosphatase NC PTPCOM1 antibody; Protein tyrosine phosphatase PCPTP1 antibody; Protein tyrosine phosphatase receptor type R antibody; Protein-tyrosine phosphatase PCPTP1 antibody; PTP SL antibody; PTPBR7 antibody; PTPRQ antibody; PTPRR antibody; PTPRR_HUMAN antibody; PTPSL antibody; R-PTP-R antibody; Receptor type tyrosine protein phosphatase R antibody; Receptor-type tyrosine-protein phosphatase R antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Receptor-type tyrosine-protein phosphatase R protein (1-412AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PTPRR Antibody (Product code: CSB-PA624019LA01HU) is Non-conjugated. For PTPRR Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA624019LB01HU PTPRR Antibody, HRP conjugated ELISA
FITC CSB-PA624019LC01HU PTPRR Antibody, FITC conjugated
Biotin CSB-PA624019LD01HU PTPRR Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus.
Gene References into Functions
  1. The PTPRR genes were related to possible endophenotypes for suicidal behaviour such as anger, depression-anxiety and fatigue. PMID: 28327445
  2. The development of MDD may be related with the polymorphism of ERK-rs12678428 and PTPRR-rs1513105. PMID: 28467119
  3. Results show that PTPRR is an early and direct target of the androgen receptor which negatively regulates the RAS/ERK1/2 pathway suggesting that its loss in prostate cancer cells is one factor that might contribute to activation of the RAS/ERK1/2 pathway. PMID: 25592066
  4. High expression of PTP receptors R and Z1 was observed in all examined cases of colorectal carcinoma, adenoma and normal colon tissue in this study. PMID: 24242166
  5. The methylation index of PTPRR recovered from scrapings of uterine cervix adenocarcinomas is significantly higher than in normal controls. PMID: 24407576
  6. 3 genes identified by association study and supported by ocular expression and/or replication, UHRF1BP1L, PTPRR, and PPFIA2, are novel candidates for myopic development within the MYP3 locus that should be further studied. PMID: 23422819
  7. Methylation of the PTPRR promoter has an important role in the metastasis and may be a biomarker of invasive cervical cancer PMID: 22330137
  8. the protein tyrosine phosphatase receptor type R gene may play a role in conferring risk of major depressive disorder in females PMID: 22100128
  9. expression of the PTPRR-1 isoform was inactivated in colorectal cancer cells as a result of de novo CpG island methylation and enrichment of transcription-repressive histone-tail marks, mainly H3K27me3 PMID: 20015382

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Subcellular Location
[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Delta]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.; [Isoform Gamma]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.
Protein Families
Protein-tyrosine phosphatase family, Receptor class 7 subfamily
Tissue Specificity
Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta,
Database Links

HGNC: 9680

OMIM: 602853

KEGG: hsa:5801

STRING: 9606.ENSP00000283228

UniGene: Hs.506076

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