PTPRR Antibody

1. The PTPRR genes were related to possible endophenotypes for suicidal behaviour such as anger, depression-anxiety and fatigue. PMID: 28327445
2. The development of MDD may be related with the polymorphism of ERK-rs12678428 and PTPRR-rs1513105. PMID: 28467119
3. Results show that PTPRR is an early and direct target of the androgen receptor which negatively regulates the RAS/ERK1/2 pathway suggesting that its loss in prostate cancer cells is one factor that might contribute to activation of the RAS/ERK1/2 pathway. PMID: 25592066
4. High expression of PTP receptors R and Z1 was observed in all examined cases of colorectal carcinoma, adenoma and normal colon tissue in this study. PMID: 24242166
5. The methylation index of PTPRR recovered from scrapings of uterine cervix adenocarcinomas is significantly higher than in normal controls. PMID: 24407576
6. 3 genes identified by association study and supported by ocular expression and/or replication, UHRF1BP1L, PTPRR, and PPFIA2, are novel candidates for myopic development within the MYP3 locus that should be further studied. PMID: 23422819
7. Methylation of the PTPRR promoter has an important role in the metastasis and may be a biomarker of invasive cervical cancer PMID: 22330137
8. the protein tyrosine phosphatase receptor type R gene may play a role in conferring risk of major depressive disorder in females PMID: 22100128
9. expression of the PTPRR-1 isoform was inactivated in colorectal cancer cells as a result of de novo CpG island methylation and enrichment of transcription-repressive histone-tail marks, mainly H3K27me3 PMID: 20015382

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HGNC: 9680

OMIM: 602853

KEGG: hsa:5801

STRING: 9606.ENSP00000283228

UniGene: Hs.506076