Recombinant Human Receptor-type tyrosine-protein phosphatase R(PTPRR),partial

Code CSB-YP624019HU
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Source Yeast
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Code CSB-EP624019HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP624019HU
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Source Baculovirus
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Code CSB-MP624019HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Ch-1PTPase; Ch1 PTPase; DKFZp781C1038; EC PTP; ECPTP; FLJ34328; MGC131968; MGC148170; NC PTPCOM1; NC-PTPCOM1; Protein tyrosine phosphatase Cr1PTPase precursor; Protein tyrosine phosphatase NC PTPCOM1; Protein tyrosine phosphatase PCPTP1; Protein tyrosine phosphatase receptor type R; Protein-tyrosine phosphatase PCPTP1; PTP SL; PTPBR7; PTPRQ; PTPRR; PTPRR_HUMAN; PTPSL; R-PTP-R; Receptor type tyrosine protein phosphatase R; Receptor-type tyrosine-protein phosphatase R
Homo sapiens (Human)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus.
Gene References into Functions
  1. The PTPRR genes were related to possible endophenotypes for suicidal behaviour such as anger, depression-anxiety and fatigue. PMID: 28327445
  2. The development of MDD may be related with the polymorphism of ERK-rs12678428 and PTPRR-rs1513105. PMID: 28467119
  3. Results show that PTPRR is an early and direct target of the androgen receptor which negatively regulates the RAS/ERK1/2 pathway suggesting that its loss in prostate cancer cells is one factor that might contribute to activation of the RAS/ERK1/2 pathway. PMID: 25592066
  4. High expression of PTP receptors R and Z1 was observed in all examined cases of colorectal carcinoma, adenoma and normal colon tissue in this study. PMID: 24242166
  5. The methylation index of PTPRR recovered from scrapings of uterine cervix adenocarcinomas is significantly higher than in normal controls. PMID: 24407576
  6. 3 genes identified by association study and supported by ocular expression and/or replication, UHRF1BP1L, PTPRR, and PPFIA2, are novel candidates for myopic development within the MYP3 locus that should be further studied. PMID: 23422819
  7. Methylation of the PTPRR promoter has an important role in the metastasis and may be a biomarker of invasive cervical cancer PMID: 22330137
  8. the protein tyrosine phosphatase receptor type R gene may play a role in conferring risk of major depressive disorder in females PMID: 22100128
  9. expression of the PTPRR-1 isoform was inactivated in colorectal cancer cells as a result of de novo CpG island methylation and enrichment of transcription-repressive histone-tail marks, mainly H3K27me3 PMID: 20015382

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Subcellular Location
[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Delta]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.; [Isoform Gamma]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.
Protein Families
Protein-tyrosine phosphatase family, Receptor class 7 subfamily
Tissue Specificity
Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta,
Database Links

HGNC: 9680

OMIM: 602853

KEGG: hsa:5801

STRING: 9606.ENSP00000283228

UniGene: Hs.506076

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