RAD51D Antibody

Datasheet

Code	CSB-PA019268ESR1HU
Size	US$166
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Image	Western blot All lanes: DNA repair protein RAD51 homolog 4 antibody at 8μg/ml + Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 36, 6, 24, 31, 13, 23, 38 kDa Observed band size: 36 kDa Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA019268ESR1HU at dilution of 1:100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RAD51D Polyclonal antibody

Uniprot No.

O75771

Target Names

RAD51D

Alternative Names

BROVCA4 antibody; DNA repair protein RAD51 homolog 4 antibody; HsTRAD antibody; OTTHUMP00000163851 antibody; OTTHUMP00000163852 antibody; OTTHUMP00000163853 antibody; R51H3 antibody; RA51D_HUMAN antibody; RAD51 homolog D (S. cerevisiae) antibody; RAD51 homolog D antibody; RAD51 like 3 (S. cerevisiae) antibody; RAD51 paralog D antibody; RAD51, S. cerevisiae, homolog of, D antibody; RAD51-like protein 3 antibody; Rad51l3 antibody; Recombination repair protein antibody; S. cerevisiae RAD51-like 3 antibody; TRAD antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DNA repair protein RAD51 homolog 4 protein (1-328AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.

Gene References into Functions

Contribution of RAD51D germline mutations in breast and ovarian cancer in Greece. PMID: 30111881
Results highlight the importance of a functional RAD51D-XRCC2 interaction to promote HR and prevent the development of HGSC. PMID: 28646019
variants in RAD51D were associated with moderate risks of breast cancer. PMID: 28418444
of Rad51d mediated by E3 Ligase Rnf138 has a role in the homologous recombination repair pathway PMID: 27195665
endogenous regulation of RAD51D by miR-103/107 was observed in several tumor subtypes; both miR-103 and miR-107 directly target and regulate RAD51 and RAD51D PMID: 24088786
We aimed to determine the prevalence of germline RAD51D mutations in Spanish breast and ovarian cancer families negative for BRCA1/BRCA2 PMID: 24130102
Our data provide additional evidence that RAD51D mutations are enriched among ovarian cancer patients, but are extremely rare among familial breast cancer patients. PMID: 23372765
loss-of-function mutations in RAD51D predispose to ovarian carcinoma but not to breast carcinoma. PMID: 22986143
RAD51D is primarily a moderate penetrance susceptibility gene for ovarian cancer, with clinical significance for the carriers. PMID: 22652533
The RAD51D should be included in genetic screening of ovarian cancer families that do not have BRCA1/BRCA2 mutations. PMID: 22415235
These data indicate that RAD51D mutation testing may have clinical utility in individuals with ovarian cancer and their families. PMID: 21822267
The N-terminal domain of Rad51D is required for the ssDNA-specific binding function of human Rad51D. PMID: 21111057
Polymorphisms in RAD51D gene is associated with breast cancer. PMID: 20054644
Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex PMID: 11834724
RAD51L3 cooperates with Bloom Syndrome Protein during the late stages of homologous recombination processes that serve to restore productive DNA replication at sites of damaged or stalled replication forks PMID: 12975363
Telomere maintenance requires RAD51D. PMID: 15109494
E233G single nucleotide polymorphism is a low-penetrance susceptibility gene in the specific subgroup of high-risk familial breast cancer cases that are not related to BRCA1/2. PMID: 15170666
Interactions between RAD51D and its XRCC2 and RAD51C partners require a functional RAD51D Walker B ATPase motif, but not motif A. PMID: 16717288
The RAD51D E233G variant is not associated with breast cancer. PMID: 18058226

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Involvement in disease

Breast-ovarian cancer, familial, 4 (BROVCA4)

Subcellular Location

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, telomere.

Protein Families

RecA family, RAD51 subfamily

Tissue Specificity

Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly expressed in leukocytes.

Database Links

HGNC: 9823

OMIM: 602954

KEGG: hsa:5892

STRING: 9606.ENSP00000466834

UniGene: Hs.631757

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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