RAD51D Antibody

1. Contribution of RAD51D germline mutations in breast and ovarian cancer in Greece. PMID: 30111881
2. Results highlight the importance of a functional RAD51D-XRCC2 interaction to promote HR and prevent the development of HGSC. PMID: 28646019
3. variants in RAD51D were associated with moderate risks of breast cancer. PMID: 28418444
4. of Rad51d mediated by E3 Ligase Rnf138 has a role in the homologous recombination repair pathway PMID: 27195665
5. endogenous regulation of RAD51D by miR-103/107 was observed in several tumor subtypes; both miR-103 and miR-107 directly target and regulate RAD51 and RAD51D PMID: 24088786
6. We aimed to determine the prevalence of germline RAD51D mutations in Spanish breast and ovarian cancer families negative for BRCA1/BRCA2 PMID: 24130102
7. Our data provide additional evidence that RAD51D mutations are enriched among ovarian cancer patients, but are extremely rare among familial breast cancer patients. PMID: 23372765
8. loss-of-function mutations in RAD51D predispose to ovarian carcinoma but not to breast carcinoma. PMID: 22986143
9. RAD51D is primarily a moderate penetrance susceptibility gene for ovarian cancer, with clinical significance for the carriers. PMID: 22652533
10. The RAD51D should be included in genetic screening of ovarian cancer families that do not have BRCA1/BRCA2 mutations. PMID: 22415235
11. These data indicate that RAD51D mutation testing may have clinical utility in individuals with ovarian cancer and their families. PMID: 21822267
12. The N-terminal domain of Rad51D is required for the ssDNA-specific binding function of human Rad51D. PMID: 21111057
13. Polymorphisms in RAD51D gene is associated with breast cancer. PMID: 20054644
14. Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex PMID: 11834724
15. RAD51L3 cooperates with Bloom Syndrome Protein during the late stages of homologous recombination processes that serve to restore productive DNA replication at sites of damaged or stalled replication forks PMID: 12975363
16. Telomere maintenance requires RAD51D. PMID: 15109494
17. E233G single nucleotide polymorphism is a low-penetrance susceptibility gene in the specific subgroup of high-risk familial breast cancer cases that are not related to BRCA1/2. PMID: 15170666
18. Interactions between RAD51D and its XRCC2 and RAD51C partners require a functional RAD51D Walker B ATPase motif, but not motif A. PMID: 16717288
19. The RAD51D E233G variant is not associated with breast cancer. PMID: 18058226

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HGNC: 9823

OMIM: 602954

KEGG: hsa:5892

STRING: 9606.ENSP00000466834

UniGene: Hs.631757