SESN2 Antibody

Code CSB-PA021096GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
DKFZp761M0212 antibody; DKFZp761M02121 antibody; Hi95 antibody; Hypoxia induced gene 95 antibody; MGC11758 antibody; OTTHUMP00000003641 antibody; OTTMUSP00000010184 antibody; RP23 63D8.3 antibody; SES2 antibody; SESN 2 antibody; SESN2 antibody; SESN2_HUMAN antibody; SEST2 antibody; Sestrin 2 antibody; Sestrin-2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SESN2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.
Gene References into Functions
  1. High serum Sestrin 2 levels are associated with metabolic synfrome. PMID: 30099048
  2. Knockdown of sesn2 aggravates atherosclerotic processes by increasing pro-inflammatory reactions and ER stress in the endothelium via an AMPK-dependent mechanism, suggesting that sesn2 might be a novel therapeutic target for atherosclerosis. PMID: 28215577
  3. SESN2 is critical to protect cells against detrimental effect of mitochondrial damage and RBX1 is a negative regulator of SESN2 which hampers its stabilization. PMID: 29294217
  4. Sesn2 ablation increased UVA-induced Nrf2 induction and inhibits UVA-induced ROS production, indicating that Sesn2 acts as an upstream regulator of Nrf2 PMID: 27463837
  5. tribbles pseudokinase 3(TRB3) and sestrin 2 may contribute to the development of obesity and its complications and can be considered interesting therapeutic target for the treatment of obesity PMID: 28639842
  6. Overexpression of Sesn2 downregulated the expression of autophagy genes, upregulated pro-apoptotic gene expression, and downregulated specific extracellular matrix markers in stress-induced cells. PMID: 29518770
  7. These results suggest that sestrin 2 suppresses CRC cell growth through activation of the AMPK/mTORC1 pathway and induction of apoptosis, and could be a novel pharmacological target for the treatment of CRC. PMID: 28525387
  8. This study shows that differential Sestrin2-mediated regulation of mTORC1 and mTORC2 is necessary for the survival of glutamine-depleted lung cancer cells. PMID: 28723563
  9. There was significant overexpression of serum sesn2 protein and mRNA levels in the Alzheimer's Disease group compared to Mild Cognitive Impairment and the control group. PMID: 27567861
  10. isorhapontigenin treatment induces autophagy and inhibits bladder cancer growth through MAPK8-JUN-dependent transcriptional induction of SESN2 PMID: 27171279
  11. simple analysis of the reported "apo"-Sestrin2 structure reveals the clear presence of prominent, unmodeled electron density in the leucine-binding pocket that exactly accommodates the leucine observed in the higher resolution structure. PMID: 27649739
  12. Mass spectrometry analysis, western blot and surface plasmon resonance (SPR) of affinity purified sesn1 and sesn2 proteins confirmed their identity; biophysical characteristics were observed using circular dichroism (CD) showing that sesn1 and sesn2 have a predominant a-helical structure. PMID: 28707664
  13. the results support a model in which leucine selectively promotes dephosphorylation of Sestrin2. PMID: 27010498
  14. The data are the first to indicate that SESN2 might be a novel prognostic marker for hepatocellular carcinoma PMID: 28118855
  15. These results highlight Sestrin2 as a novel tumor suppressor, whose downregulation can accelerate both colitis and colon carcinogenesis. PMID: 26913956
  16. The up-regulation of SESN2 by mitochondrial dysfunction requires binding to ATF4. PMID: 26771712
  17. Sestrin2 silencing strongly inhibits cytokine-induced cell death. PMID: 26313705
  18. Sesn2 has two subdomains. The N-terminal domain reduces alkylhydroperoxide radicals through its helix-turn-helix oxidoreductase motif, and the C-terminal domain interacts with GATOR2 and subsequently inhibits mTORC1. PMID: 26612684
  19. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes PMID: 25819761
  20. Sestrin2: A Promising Therapeutic Target for Liver Diseases PMID: 26133704
  21. SESN2-AMPK signaling could exert a protective effect against glucose deprivation-induced cell death and that this effect is mediated by restoration of mitochondrial function. PMID: 25778901
  22. Sesn2 is a potential tumor suppressor in lung epithelial cells. The expression level of Sesn2 may serve as a prognostic marker for Chinese lung cancer patients in the clinic. PMID: 25962159
  23. These results indicate that Sestrin2 is a leucine sensor for the mTORC1 pathway. PMID: 26449471
  24. this study presents the 2.7 angstrom crystal structure of Sestrin2 in complex with leucine. PMID: 26586190
  25. knockdown of Sestrin2 using small RNA interference promotes cell apoptosis and reactive oxygen species production induced by oxLDL. PMID: 25692450
  26. The findings suggested that a decreased expression of sestrin 2 is associated with an unfavorable prognosis, which suggests that it is a novel and crucial predictor for colorectal cancer metastasis. PMID: 25572852
  27. Sestrin2 has a hepatoprotective role against chronic ER stress PMID: 24947615
  28. an AMPK-independent mechanism of mTORC1 inhibition by Sestrins mediated by their interaction with GATOR2, is reported. PMID: 25457612
  29. GAA promotes FoxO3 nuclear translocation and binding to the SESN2 enhancer. PMID: 25802279
  30. Data indicate that inactivation of Sestrin 2 (Sesn2) or nuclear factor erythroid 2-related factor 2 (Nrf2) induced reactive oxygen species-mediated proteasomal inhibition and platelet-derived growth factor receptor beta (Pdgfrbeta) accumulation. PMID: 25716320
  31. Sesn2 is oncogenic in skin squamous cell carcinoma and melanoma. PMID: 25378405
  32. knockdown of SESN2 using small RNA interference promotes cellular toxicity of angiotensin II, as well as a reduction in cell viability, exacerbation of oxidative stress, and stimulation of apoptosis. PMID: 24838122
  33. Data indicate that sestrin2 expression is upregulated by dopamine D2 receptor. PMID: 25024286
  34. Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. PMID: 24825887
  35. results show that ATF4-regulated SESN2 expression presents a new link between ER stress and mTOR inhibition and autophagy. PMID: 23916134
  36. results imply that SESN2 could serve as both a biomarker and as a drug target in the clinical management of COPD PMID: 24046361
  37. Sesn2 as a new energetic stress sensor, which appears to be protective against energetic stress-induced apoptosis that integrates the pro-survival function of Akt and the negative regulation of mTOR. PMID: 23238567
  38. The JNK pathway mediated sestrin 2 expression and contributed to autophagy induction, highlighting the relationship of sestrin 2 and autophagy and the JNK signaling pathway. PMID: 22982090
  39. Sestrin-2 redistributes to neuronal soma in human immunodeficiency virus (HIV)-associated neurocognitive disorders. PMID: 22450766
  40. Sesn2 is required for the Nrf2-mediated cytoprotective activity against hydrogen peroxide PMID: 22749810
  41. In breast cancer cells SESN2 is associated with AMPK. PMID: 22363791
  42. Signalling by the AMP-activated protein kinase was also involved as a downstream target of sestrin2. PMID: 21418191
  43. PDGFRbeta accumulation is associated with increased oxidative stress and cellular damage in SESN2 silenced human glioblastoma U87 cells. PMID: 21536039
  44. results suggest that, unlike Srx, Sesn 2 is not a sulfinic Prx reductase PMID: 19113821
  45. results show that sestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of peroxiredoxins containing Cys-SO(2)H PMID: 15105503
  46. depletion of Sestrin2 or Dram failed to affect autophagy in p53-deficient cells PMID: 19377293

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Subcellular Location
Cytoplasm.
Protein Families
Sestrin family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 20746

OMIM: 607767

KEGG: hsa:83667

STRING: 9606.ENSP00000253063

UniGene: Hs.469543

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