Recombinant Human Sestrin-2 (SESN2)

1. High serum Sestrin 2 levels are associated with metabolic synfrome. PMID: 30099048
2. Knockdown of sesn2 aggravates atherosclerotic processes by increasing pro-inflammatory reactions and ER stress in the endothelium via an AMPK-dependent mechanism, suggesting that sesn2 might be a novel therapeutic target for atherosclerosis. PMID: 28215577
3. SESN2 is critical to protect cells against detrimental effect of mitochondrial damage and RBX1 is a negative regulator of SESN2 which hampers its stabilization. PMID: 29294217
4. Sesn2 ablation increased UVA-induced Nrf2 induction and inhibits UVA-induced ROS production, indicating that Sesn2 acts as an upstream regulator of Nrf2 PMID: 27463837
5. tribbles pseudokinase 3(TRB3) and sestrin 2 may contribute to the development of obesity and its complications and can be considered interesting therapeutic target for the treatment of obesity PMID: 28639842
6. Overexpression of Sesn2 downregulated the expression of autophagy genes, upregulated pro-apoptotic gene expression, and downregulated specific extracellular matrix markers in stress-induced cells. PMID: 29518770
7. These results suggest that sestrin 2 suppresses CRC cell growth through activation of the AMPK/mTORC1 pathway and induction of apoptosis, and could be a novel pharmacological target for the treatment of CRC. PMID: 28525387
8. This study shows that differential Sestrin2-mediated regulation of mTORC1 and mTORC2 is necessary for the survival of glutamine-depleted lung cancer cells. PMID: 28723563
9. There was significant overexpression of serum sesn2 protein and mRNA levels in the Alzheimer's Disease group compared to Mild Cognitive Impairment and the control group. PMID: 27567861
10. isorhapontigenin treatment induces autophagy and inhibits bladder cancer growth through MAPK8-JUN-dependent transcriptional induction of SESN2 PMID: 27171279
11. simple analysis of the reported "apo"-Sestrin2 structure reveals the clear presence of prominent, unmodeled electron density in the leucine-binding pocket that exactly accommodates the leucine observed in the higher resolution structure. PMID: 27649739
12. Mass spectrometry analysis, western blot and surface plasmon resonance (SPR) of affinity purified sesn1 and sesn2 proteins confirmed their identity; biophysical characteristics were observed using circular dichroism (CD) showing that sesn1 and sesn2 have a predominant a-helical structure. PMID: 28707664
13. the results support a model in which leucine selectively promotes dephosphorylation of Sestrin2. PMID: 27010498
14. The data are the first to indicate that SESN2 might be a novel prognostic marker for hepatocellular carcinoma PMID: 28118855
15. These results highlight Sestrin2 as a novel tumor suppressor, whose downregulation can accelerate both colitis and colon carcinogenesis. PMID: 26913956
16. The up-regulation of SESN2 by mitochondrial dysfunction requires binding to ATF4. PMID: 26771712
17. Sestrin2 silencing strongly inhibits cytokine-induced cell death. PMID: 26313705
18. Sesn2 has two subdomains. The N-terminal domain reduces alkylhydroperoxide radicals through its helix-turn-helix oxidoreductase motif, and the C-terminal domain interacts with GATOR2 and subsequently inhibits mTORC1. PMID: 26612684
19. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes PMID: 25819761
20. Sestrin2: A Promising Therapeutic Target for Liver Diseases PMID: 26133704
21. SESN2-AMPK signaling could exert a protective effect against glucose deprivation-induced cell death and that this effect is mediated by restoration of mitochondrial function. PMID: 25778901
22. Sesn2 is a potential tumor suppressor in lung epithelial cells. The expression level of Sesn2 may serve as a prognostic marker for Chinese lung cancer patients in the clinic. PMID: 25962159
23. These results indicate that Sestrin2 is a leucine sensor for the mTORC1 pathway. PMID: 26449471
24. this study presents the 2.7 angstrom crystal structure of Sestrin2 in complex with leucine. PMID: 26586190
25. knockdown of Sestrin2 using small RNA interference promotes cell apoptosis and reactive oxygen species production induced by oxLDL. PMID: 25692450
26. The findings suggested that a decreased expression of sestrin 2 is associated with an unfavorable prognosis, which suggests that it is a novel and crucial predictor for colorectal cancer metastasis. PMID: 25572852
27. Sestrin2 has a hepatoprotective role against chronic ER stress PMID: 24947615
28. an AMPK-independent mechanism of mTORC1 inhibition by Sestrins mediated by their interaction with GATOR2, is reported. PMID: 25457612
29. GAA promotes FoxO3 nuclear translocation and binding to the SESN2 enhancer. PMID: 25802279
30. Data indicate that inactivation of Sestrin 2 (Sesn2) or nuclear factor erythroid 2-related factor 2 (Nrf2) induced reactive oxygen species-mediated proteasomal inhibition and platelet-derived growth factor receptor beta (Pdgfrbeta) accumulation. PMID: 25716320
31. Sesn2 is oncogenic in skin squamous cell carcinoma and melanoma. PMID: 25378405
32. knockdown of SESN2 using small RNA interference promotes cellular toxicity of angiotensin II, as well as a reduction in cell viability, exacerbation of oxidative stress, and stimulation of apoptosis. PMID: 24838122
33. Data indicate that sestrin2 expression is upregulated by dopamine D2 receptor. PMID: 25024286
34. Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. PMID: 24825887
35. results show that ATF4-regulated SESN2 expression presents a new link between ER stress and mTOR inhibition and autophagy. PMID: 23916134
36. results imply that SESN2 could serve as both a biomarker and as a drug target in the clinical management of COPD PMID: 24046361
37. Sesn2 as a new energetic stress sensor, which appears to be protective against energetic stress-induced apoptosis that integrates the pro-survival function of Akt and the negative regulation of mTOR. PMID: 23238567
38. The JNK pathway mediated sestrin 2 expression and contributed to autophagy induction, highlighting the relationship of sestrin 2 and autophagy and the JNK signaling pathway. PMID: 22982090
39. Sestrin-2 redistributes to neuronal soma in human immunodeficiency virus (HIV)-associated neurocognitive disorders. PMID: 22450766
40. Sesn2 is required for the Nrf2-mediated cytoprotective activity against hydrogen peroxide PMID: 22749810
41. In breast cancer cells SESN2 is associated with AMPK. PMID: 22363791
42. Signalling by the AMP-activated protein kinase was also involved as a downstream target of sestrin2. PMID: 21418191
43. PDGFRbeta accumulation is associated with increased oxidative stress and cellular damage in SESN2 silenced human glioblastoma U87 cells. PMID: 21536039
44. results suggest that, unlike Srx, Sesn 2 is not a sulfinic Prx reductase PMID: 19113821
45. results show that sestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of peroxiredoxins containing Cys-SO(2)H PMID: 15105503
46. depletion of Sestrin2 or Dram failed to affect autophagy in p53-deficient cells PMID: 19377293

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HGNC: 20746

OMIM: 607767

KEGG: hsa:83667

STRING: 9606.ENSP00000253063

UniGene: Hs.469543