Name: SLC38A2 Antibody
Brand: CUSABIO
SKU: CSB-PA847210LA01HU

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC38A2 Polyclonal antibody

Uniprot No.

Q96QD8

Target Names

SLC38A2

Alternative Names

Amino acid transporter 2 antibody; Amino acid transporter A2 antibody; ATA2 antibody; KIAA1382 antibody; PRO1068 antibody; Protein 40-9-1 antibody; S38A2_HUMAN antibody; SAT2 antibody; Slc38a2 antibody; SNAT2 antibody; Sodium-coupled neutral amino acid transporter 2 antibody; Solute carrier family 38 member 2 antibody; System A amino acid transporter antibody; System A amino acid transporter 2 antibody; System A transporter 1 antibody; System N amino acid transporter 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Sodium-coupled neutral amino acid transporter 2 protein (1-76AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SLC38A2 Antibody (Product code: CSB-PA847210LA01HU) is Non-conjugated. For SLC38A2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA847210LB01HU	SLC38A2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA847210LC01HU	SLC38A2 Antibody, FITC conjugated
Biotin	CSB-PA847210LD01HU	SLC38A2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The SLC38A2 antibody is produced in the rabbit immunized with the partial recombinant protein corresponding to the topological domain of human SLC38A2 protein. It is available as the unconjugated IgG isoform. It only reacts with human SLC38A2 protein. Its purity is 95%+ using protein G purified. It has been validated for use in ELISA, WB， IHC, and IF applications. The target protein of this antibody is SLC38A2 protein, which is expressed both in the fetus and placenta and plays a crucial role in the control of fetal growth and development.

Target Background

Function

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.

Gene References into Functions

there is a disulfide bond between Cys245 and Cys279 in SNAT2 which has no effect on cell surface trafficking, as well as transporter function PMID: 27355203
In the absence of SLC1A5 there is a crucial role of SNAT1 in supplying glutamine for glutaminolysis with SNAT2 acting as a "backup" for glutamine transport. PMID: 27129276
Propose regulation of placental SNAT2/LAT1 ubiquitination by mTORC1 and Nedd4-2. PMID: 26608079
Decreased placental mTOR activity causes down-regulation of placental system A activity by shifting SNAT-2 trafficking towards proteasomal degradation, thereby contributing to decreased fetal amino acid availability and restricted fetal growth in IUGR. PMID: 26374858
GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter SNAT2. PMID: 26041779
Increased availability of unsaturated fatty acids can compromise the stress-induced induction/adaptation in SNAT2 expression. PMID: 25653282
SLC38A1 and SLC38A2 transcript levels are altered in placental malaria with intervillositis. PMID: 23408887
SNAT2 mRNA levels were significantly decreased in intrauterine growth-restricted placentas with reduced umbilical blood flows. PMID: 23728383
Placental mRNA expression of system A transporter isoforms SLC38A1 and -2 was lower in teenagers than in adults which may underlie their susceptibility to delivering small-for-gestational-age infants. PMID: 22028413
findings show methylation status of rRNA differentially influenced the mechanism of 80S complex formation on IRES elements from SNAT2)versus the hepatitis C virus mRNA PMID: 21930789
Proteomic analysis of TAP-tag purified SNAT2 fusion proteins identified two novel SNAT2-interacting proteins that may potentially function in conjunction with SNAT2 transceptor to regulate signalling pathways influencing protein turnover and cell growth PMID: 21622135
Lower placental system A activity in women who reported strenuous exercise and had a lower arm muscle area may reflect an adaptation in placental function which protects maternal resources in those with lower nutrient reserves. PMID: 20206993
SNAT2 amino acid response element, along with a nearby conserved CAAT box, has enhancer activity and it confers regulated transcription to a heterologous promoter PMID: 14623874
The synthesis of SNAT2 is required for the hypertonic stimulation of system A transport activity. PMID: 15581851
Up-regulation of SNAT2 is essential for the rapid restoration of cell volume after hypertonic stress. PMID: 15922329
Amino acid depletion was associated with an up-regulation of amino acid transport system A activity, largely mediated through an enhancement of SNAT2 expression at both the protein and mRNA level in BeWo cells. PMID: 16125834
deficient in the amino acid response pathway exhibited little or no induction of SNAT2 mRNA PMID: 16445384
The strong expression of Na(+)-coupled neutral amino acid transporter 2 in the somato-dendritic compartment and in non-neuronal elements that are integral parts of the blood-brain and brain-cerebrospinal fluid barrier. PMID: 16616430
SNAT2 expression can be modulated by specific signaling pathways in response to different stresses PMID: 16621798
Results suggest that cortisol may be involved in upregulation of system A (SNAT2)in the placenta to ensure sufficient amino acid supply to the developing fetus. PMID: 16621896
Therefore, we can speculate that such anion-conducting pathways are general features of Na+-transporting systems. PMID: 17237199
Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed PMID: 18697751
Report SNAT2 activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
analysis of a conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 PMID: 19589777
we have identified a novel regulatory pathway involving increased gene expression of the SNAT2 isoform mediated by a STAT-dependent pathway, which links IL-6 to increased activity of amino acid transporter system A PMID: 19741197

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Amino acid/polyamine transporter 2 family

Tissue Specificity

Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein

Database Links

HGNC: 13448

OMIM: 605180

KEGG: hsa:54407

STRING: 9606.ENSP00000256689

UniGene: Hs.221847

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Code	CSB-PA847210LA01HU
Size	US$166
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Image	Western blot All lanes: SLC38A2 antibody at 1.5µg/ml + A431 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 57, 46 kDa Observed band size: 57 kDa Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA847210LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA847210LA01HU at dilution of 1:100 Immunofluorescent analysis of A431 cells using CSB-PA847210LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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SLC38A2 Antibody

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