SLC38A2

The protein encoded by SLC38A2 is sodium-coupled neutral amino acid transporter 2 (SNAT2), a member of the solute carrier family 38. It functions as a sodium-dependent transporter mediating the uptake of small neutral amino acids, including glutamine and alanine, across the plasma membrane. SNAT2 plays a key role in cellular amino acid homeostasis and nutrient sensing, particularly in response to mTOR signaling pathway activation under amino acid-replete conditions.
Aberrant SLC38A2 expression has been linked to cancer progression, as increased SNAT2 activity supports rapid tumor cell proliferation by enhancing amino acid availability. In glioblastoma and breast cancer models, SNAT2 upregulation correlates with tumor growth and resistance to therapy. Preclinical studies are investigating small-molecule inhibitors targeting SNAT2 as potential anticancer agents, aiming to disrupt amino acid supply and suppress mTOR-driven oncogenic pathways.

Popular Product:

SLC38A2 Antibody (CSB-PA847210LA01HU)

Validated Data

Western Blot
Positive WB detected in: A431 whole cell lysate(30µg), HepG2 whole cell lysate(30µg), BxPC-3 whole cell lysate(30µg), PC-3 whole cell lysate(30µg), Hela whole cell lysate(30µg), A549 whole cell lysate(30µg),MCF7 whole cell lysate(30µg),Mouse Brain tissue lysate(30µg)
All lanes: SLC38A2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 57,46 kDa
Observed band size: 57 kDa
Exposure time: 120s

Immunofluorescence staining of A431 cell with CSB-PA847210LA01HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunofluorescence staining of A431 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The following SLC38A2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

SLC38A2 Antibodies

SLC38A2 Proteins

SLC38A2 Antibodies

SLC38A2 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA030122	SLC38A2 Antibody	Human	WB, ELISA
CSB-PA847210LA01HU	SLC38A2 Antibody	Human, Mouse	ELISA, WB, IF
CSB-PA847210LD01HU	SLC38A2 Antibody, Biotin conjugated	Human	ELISA
CSB-PA847210LC01HU	SLC38A2 Antibody, FITC conjugated	Human
CSB-PA847210LB01HU	SLC38A2 Antibody, HRP conjugated	Human	ELISA

SLC38A2 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA716323XA01DIL	slc38a2 Antibody	Danio rerio (Zebrafish) (Brachydanio rerio)	ELISA, WB (ensure identification of antigen)

SLC38A2 Proteins

SLC38A2 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP691664CH CSB-EP691664CH CSB-BP691664CH CSB-MP691664CH CSB-EP691664CH-B	Recombinant Chicken Sodium-coupled neutral amino acid transporter 2 (SLC38A2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SLC38A2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Source
CSB-YP716323DIL CSB-EP716323DIL CSB-BP716323DIL CSB-MP716323DIL CSB-EP716323DIL-B	Recombinant Danio rerio Sodium-coupled neutral amino acid transporter 2 (slc38a2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SLC38A2 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Code	Product Name	Source
CSB-YP730371XBF CSB-EP730371XBF CSB-BP730371XBF CSB-MP730371XBF CSB-EP730371XBF-B	Recombinant Xenopus tropicalis Sodium-coupled neutral amino acid transporter 2 (slc38a2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SLC38A2 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP804500MO CSB-EP804500MO CSB-BP804500MO CSB-MP804500MO CSB-EP804500MO-B	Recombinant Mouse Sodium-coupled neutral amino acid transporter 2 (Slc38a2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SLC38A2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP847210HU CSB-EP847210HU CSB-BP847210HU CSB-MP847210HU CSB-EP847210HU-B	Recombinant Human Sodium-coupled neutral amino acid transporter 2 (SLC38A2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SLC38A2 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP864308RA CSB-EP864308RA CSB-BP864308RA CSB-MP864308RA CSB-EP864308RA-B	Recombinant Rat Sodium-coupled neutral amino acid transporter 2 (Slc38a2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SLC38A2 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP021617BO CSB-EP021617BO CSB-BP021617BO CSB-MP021617BO CSB-EP021617BO-B	Recombinant Bovine Sodium-coupled neutral amino acid transporter 2 (SLC38A2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SLC38A2 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

Code	Product Name	Source
CSB-YP021617EQU CSB-EP021617EQU CSB-BP021617EQU CSB-MP021617EQU CSB-EP021617EQU-B	Recombinant Pan paniscus Sodium-coupled neutral amino acid transporter 2 (SLC38A2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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