STAM2 Antibody

Code CSB-PA004166
Size US$100
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  • Western Blot analysis of NIH-3T3 cells using STAM2 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
STAM2
Alternative Names
DKFZp564C047 antibody; Hbp antibody; Hrs-binding protein antibody; HSE1 homolog antibody; Signal transducing adapter molecule 2 antibody; Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 antibody; Signal transducing adaptor molecule 2A antibody; Signal transducing adaptor molecule 2B antibody; Signal transducing adaptor molecule antibody; STAM like protein containing SH3 and ITAM domains 2 antibody; STAM-2 antibody; Stam2 antibody; STAM2_HUMAN antibody; STAM2A antibody; STAM2B antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from Human STAM2 around the non-phosphorylation site of Y192.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Gene References into Functions
  1. The authors propose a structural organization where the AMSH-SH3 binding motif interacts with the STAM2-SH3 domain and contributes to the correct positioning of AMSH prior to polyubiquitin chains' cleavage. PMID: 27725184
  2. The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains PMID: 26601948
  3. correlation between the percentage of STAM2-positive cells and mitotic count was statistically significant in Gastrointestinal stromal tumors PMID: 24778033
  4. The study reports the solution NMR structure of the STAM2-VHS domain in complex with monoubiquitin by means of chemical shift perturbations, spin relaxation, and paramagnetic relaxation enhancements. PMID: 21121635
  5. the SH3 domain of STAM2 plays versatile roles in the context of ubiquitin mediated receptor sorting PMID: 22841719
  6. Mice carrying a gene trap insertion in the Stam2 transgene do not reveal phenotype changes; therefore, STAM2 function in the digestive tube remains elusive. PMID: 22140097
  7. report the interactions of the UIM domain and VHS-UIM construct of STAM2 with monoubiquitin (Ub), Lys(48)- and Lys(63)-linked diubiquitins. PMID: 22493438
  8. PTP1B targets the endosomal sorting machinery; dephosphorylation of regulatory sites on the endosomal sorting complex is required for transport component STAM2 PMID: 20504764
  9. Data suggested that association with hepatocyte growth factor-regulated tyrosine kinase substrate is a prerequisite for STAM2 function in early endosome. PMID: 15113837
  10. Rin1 regulates EGFR degradation in cooperation with STAM PMID: 17403676
  11. STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex PMID: 19054391

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Subcellular Location
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Families
STAM family
Tissue Specificity
Ubiquitously expressed.
Database Links

HGNC: 11358

OMIM: 606244

KEGG: hsa:10254

STRING: 9606.ENSP00000263904

UniGene: Hs.17200

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